scholarly journals A Contact Antitumor Activity of Bacillus natto on Solid Type Ehrlich Carcinoma Cells

1968 ◽  
Vol 16 (1) ◽  
pp. 186-187 ◽  
Author(s):  
YUKIHIKO KAMEDA ◽  
SHOICHI KANATOMO ◽  
YUKIO KAMEDA ◽  
YOKO SAITO
Keyword(s):  
Antitumor Activity ◽  
Carcinoma Cells ◽  
Ehrlich Carcinoma ◽  
Bacillus Natto ◽  
Solid Type

scholarly journals Antitumor Activity of Bacillus natto. VI. Analysis of Cytolytic Activity on Ehrlich Ascites Carcinoma Cells in the Culture Medium of Bacillus natto KMD 1126

1978 ◽  
Vol 98 (10) ◽  
pp. 1432-1435 ◽  
Author(s):  
YUKIO KAMEDA ◽  
SHOICHI KANATOMO ◽  
KATSUHIKO MATSUI ◽  
TOSHIKATSU NAKABAYASHI ◽  
KAZUYUKI UENO ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Culture Medium ◽  
Ehrlich Ascites Carcinoma ◽  
Cytolytic Activity ◽  
Carcinoma Cells ◽  
Bacillus Natto ◽  
Ehrlich Ascites

ANTITUMOR EFFECT OF COLLOIDAL SILVER BISILICATE IN EXPERIMENTAL IN VITRO AND IN VIVO STUDIES

2019 ◽  
Vol 65 (5) ◽  
pp. 760-765
Author(s):  
Margarita Tyndyk ◽  
Irina Popovich ◽  
A. Malek ◽  
R. Samsonov ◽  
N. Germanov ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Tumor Growth ◽  
Tumor Cells ◽  
Human Tumor ◽  
Significant Inhibition ◽  
In Vivo Studies ◽  
Ehrlich Carcinoma ◽  
In Vivo Experiments

The paper presents the results of the research on the antitumor activity of a new drug - atomic clusters of silver (ACS), the colloidal solution of nanostructured silver bisilicate Ag6Si2O7 with particles size of 1-2 nm in deionized water. In vitro studies to evaluate the effect of various ACS concentrations in human tumor cells cultures (breast cancer, colon carcinoma and prostate cancer) were conducted. The highest antitumor activity of ACS was observed in dilutions from 2.7 mg/l to 5.1 mg/l, resulting in the death of tumor cells in all studied cell cultures. In vivo experiments on transplanted Ehrlich carcinoma model in mice consuming 0.75 mg/kg ACS with drinking water revealed significant inhibition of tumor growth since the 14th day of experiment (maximally by 52% on the 28th day, p < 0.05) in comparison with control. Subcutaneous injections of 2.5 mg/kg ACS inhibited Ehrlich's tumor growth on the 7th and 10th days of the experiment (p < 0.05) as compared to control.

scholarly journals Cryopreservation effect on structural-functional characteristics of Ehrlich carcinoma cells

2014 ◽  
Vol 24 (2) ◽  
pp. 163-163
Author(s):  
Olga A. Diabina ◽  
◽  
Maksim V. Ostankov ◽  
Nikolay A. Bondarovich ◽  
Anatoliy N. Goltsev ◽  
...  
Keyword(s):  
Carcinoma Cells ◽  
Ehrlich Carcinoma ◽  
Functional Characteristics

scholarly journals Role of Irradiated Ehrlich Carcinoma cells and IFNα-2b immunomodulator in Regression of Ehrlich carcinoma in Mice

2014 ◽  
Vol 9 (1) ◽  
pp. 91-112
Author(s):  
Neamat HA Osman ◽  
Faten M Zahran ◽  
Rokaia E Maarouf
Keyword(s):  
Carcinoma Cells ◽  
Ehrlich Carcinoma

„IN VITRO“ AND „IN VIVO“ ANTITUMOR ACTIVITY OF PLATINUM(II) COMPLEXES WITH MALONIC ACID ON BREAST AND COLORECTAL CARCINOMA CELL LINES

2021 ◽  
Author(s):  
Andjela Franich ◽  
◽  
Milica Dimitrijević Stojanović ◽  
Snežana Rajković ◽  
Marina Jovanović ◽  
...  
Keyword(s):  
Antitumor Activity ◽  
Colorectal Carcinoma ◽  
Cell Lines ◽  
Tumor Model ◽  
Carcinoma Cells ◽  
Spectroscopic Techniques ◽  
Murine Cell Line ◽  
In Vivo Antitumor Activity

Four Pt(II) complexes of the general formula [Pt(L)(5,6-epoxy-1,10-phen)], where L is anion of malonic (mal, Pt1), 2-methylmalonic (Me-mal, Pt2), 2,2-dimethylmalonic (Me2-mal, Pt3) or 1,1- cyclobutanedicarboxylic (CBDCA, Pt4) acid while 5,6-epoxy-1,10-phen is bidentately coordinated 5,6-epoxy-5,6-dihydro-1,10-phenanthroline were synthesized and characterized by elemental microanalysis, IR, UV-Vis and NMR (1H and 13C) spectroscopic techniques. In vitro anticancer activity of novel platinum(II) complexes have been investigated on human and murine cancer cell lines, as well as normal murine cell line by MTT assay. The obtained results indicate that studied platinum(II) complexes exhibited strong cytotoxic activity against murine breast carcinoma cells (4T1), human (HCT116) and murine (CT26) colorectal carcinoma cells. Complex Pt3 display stronger selectivity toward carcinoma cells in comparison to other tested platinum(II) complexes exhibiting beneficial antitumor activity mainly via the induction of apoptosis, as well as inhibition of cell proliferation and migration. Further study showed that Pt3 complex also carry significant in vivo antitumor activity in orthotopical 4T1 tumor model without detected liver, kidney, lung, and heart toxicity. All results imply that these novel platinum(II) complexes have a good anti-tumor effect on breast and colorectal cancer in vivo and in vitro and the affinity to become possible candidates for treatment in anticancer therapy.

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