scholarly journals Effects of chronic administration of perfluorooctanoic acid on fatty acid metabolism in rat liver: Relationship among stearoyl-coenzyme A desaturase, 1-acylglycerophosphocholine acyltransferase, and acyl composition of microsomal phosphatidylcholine.

1990 ◽  
Vol 13 (9) ◽  
pp. 581-590 ◽  
Author(s):  
Narcisa UYYU ◽  
Yoichi KAWASHIMA ◽  
Sachiko HORII ◽  
Hiroshi KOZUKA
Keyword(s):  
Fatty Acid ◽  
Rat Liver ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Coenzyme A ◽  
Chronic Administration ◽  
Perfluorooctanoic Acid ◽  
Acyl Composition

Age-related changes of long-chain fatty acid metabolism in rat liver

1988 ◽  
Vol 44 (2) ◽  
pp. 175-183 ◽  
Author(s):  
Seijiro Mori ◽  
Nobuhiro Morisaki ◽  
Yasushi Saito ◽  
Sho Yoshida
Keyword(s):  
Fatty Acid ◽  
Rat Liver ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Chain Fatty Acid ◽  
Long Chain Fatty Acid ◽  
Age Related ◽  
Long Chain ◽  
Age Related Changes

Altered fatty acid metabolism and reduced stearoyl-coenzyme a desaturase activity in asthma

Allergy ◽  
2017 ◽  
Vol 72 (11) ◽  
pp. 1744-1752 ◽  
Author(s):  
N. Rodriguez-Perez ◽  
E. Schiavi ◽  
R. Frei ◽  
R. Ferstl ◽  
P. Wawrzyniak ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Desaturase Activity ◽  
Acid Metabolism ◽  
Coenzyme A

scholarly journals Effects of L-Carnitine on Fatty Acid Metabolism in Regenerating Rat Liver

1990 ◽  
Vol 42 (Supplement) ◽  
pp. S30-S42 ◽  
Author(s):  
Takaya Tanaka ◽  
Daisuke Takagi ◽  
Naoshi Takeyama ◽  
Yashultide Kitazawa
Keyword(s):  
Fatty Acid ◽  
Rat Liver ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Regenerating Rat Liver

Altered hepatic fatty acid metabolism in endotoxicosis: effect of L-carnitine on survival

1989 ◽  
Vol 256 (1) ◽  
pp. E31-E38 ◽  
Author(s):  
N. Takeyama ◽  
D. Takagi ◽  
N. Matsuo ◽  
Y. Kitazawa ◽  
T. Tanaka
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Coenzyme A ◽  
Ketone Bodies ◽  
Oxidation Treatment ◽  
Hepatic Fatty Acid ◽  
Malonyl Coa ◽  
Carnitine Derivatives

The activities of palmitoyl-coenzyme A (CoA) synthetase, carnitine acetyltransferase (CAT), and carnitine palmitoyltransferase (CPT) and the levels of ketone bodies, reduced coenzyme A (CoASH), carnitine, and their esters, which are involved in fatty acid metabolism, in rat liver and plasma were measured after the administration of Escherichia coli lipopolysaccharide (LPS). We also studied the effect of L-carnitine treatment before LPS administration on survival and on hepatic fatty acid metabolism. The activities of CAT and CPT and the concentrations of ketone bodies, CoA, and carnitine derivatives (except for malonyl-CoA) declined in the liver after LPS administration. The activity of palmitoyl-CoA synthetase was changed little after LPS administration, and the level of hepatic malonyl-CoA increased significantly, suggesting that LPS causes activated fatty acids to undergo esterification and lipogenesis rather than oxidation. Treatment of rats with L-carnitine before LPS greatly increased the survival rate, but did not affect enzymes that metabolize fatty acids, CoA, or carnitine derivatives in the liver. Further studies are necessary to elucidate the mechanism of the effect of carnitine on post-LPS survival.

scholarly journals Acyl Coenzyme A Thioesterase 7 Regulates Neuronal Fatty Acid Metabolism To Prevent Neurotoxicity

2013 ◽  
Vol 33 (9) ◽  
pp. 1869-1882 ◽  
Author(s):  
Jessica M. Ellis ◽  
G. William Wong ◽  
Michael J. Wolfgang
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Coenzyme A ◽  
Neurological Diseases ◽  
Conditional Knockout ◽  
Neurological Dysfunction ◽  
Chain Acyl ◽  
Acyl Coenzyme A ◽  
Long Chain

Numerous neurological diseases are associated with dysregulated lipid metabolism; however, the basic metabolic control of fatty acid metabolism in neurons remains enigmatic. Here we have shown that neurons have abundant expression and activity of the long-chain cytoplasmic acyl coenzyme A (acyl-CoA) thioesterase 7 (ACOT7) to regulate lipid retention and metabolism. Unbiased and targeted metabolomic analysis of fasted mice with a conditional knockout of ACOT7 in the nervous system, Acot7 N−/− , revealed increased fatty acid flux into multiple long-chain acyl-CoA-dependent pathways. The alterations in brain fatty acid metabolism were concomitant with a loss of lean mass, hypermetabolism, hepatic steatosis, dyslipidemia, and behavioral hyperexcitability in Acot7 N − / − mice. These failures in adaptive energy metabolism are common in neurodegenerative diseases. In agreement, Acot7 N − / − mice exhibit neurological dysfunction and neurodegeneration. These data show that ACOT7 counterregulates fatty acid metabolism in neurons and protects against neurotoxicity.

scholarly journals The rapid preparation of peroxisomes from rat liver by using a vertical rotor

1979 ◽  
Vol 180 (2) ◽  
pp. 445-448 ◽  
Author(s):  
C E Neat ◽  
H Osmundsen
Keyword(s):  
Fatty Acid ◽  
Rat Liver ◽  
Fatty Acid Metabolism ◽  
Acid Metabolism ◽  
Density Gradient Centrifugation ◽  
Gradient Centrifugation ◽  
Sucrose Density Gradient ◽  
Sucrose Density Gradient Centrifugation ◽  
Rapid Preparation ◽  
Vertical Rotor

A method is described for the rapid preparation of peroxisomes from rat liver by using sucrose-density-gradient centrifugation in a vertical rotor. The preparation, shown to be virtually free of mitochondrial and microsomal contamination, can be used to study fatty acid metabolism by isolated peroxisomes.

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