scholarly journals Neuroinflammation, Oxidative Stress, and Neurogenesis in a Mouse Model of Chronic Fatigue Syndrome, and the Treatment with Kampo Medicine

2020 ◽  
Vol 43 (1) ◽  
pp. 110-115
Author(s):  
Qiang He ◽  
Mio Sawada ◽  
Naruhiro Yamasaki ◽  
Sumiyo Akazawa ◽  
Hisakazu Furuta ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Fatigue Syndrome ◽  
Mouse Model ◽  
Chronic Fatigue ◽  
Kampo Medicine ◽  
Fatigue Syndrome

Effect of Natural and Synthetic Antioxidants in a Mouse Model of Chronic Fatigue Syndrome

2002 ◽  
Vol 5 (4) ◽  
pp. 211-220 ◽  
Author(s):  
Amanpreet Singh ◽  
Pattipati S. Naidu ◽  
Saraswati Gupta ◽  
Shrinivas K. Kulkarni
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Mouse Model ◽  
Chronic Fatigue ◽  
Synthetic Antioxidants ◽  
Fatigue Syndrome ◽  
Natural And Synthetic

scholarly journals Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients

Metabolomics ◽  
2015 ◽  
Vol 11 (6) ◽  
pp. 1626-1639 ◽  
Author(s):  
Christopher W. Armstrong ◽  
Neil R. McGregor ◽  
Donald P. Lewis ◽  
Henry L. Butt ◽  
Paul R. Gooley
Keyword(s):  
Oxidative Stress ◽  
Energy Metabolism ◽  
Chronic Fatigue Syndrome ◽  
Metabolic Profiling ◽  
Chronic Fatigue ◽  
Fatigue Syndrome ◽  
And Oxidative Stress

scholarly journals Differential heat shock protein responses to strenuous standardized exercise in chronic fatigue syndrome patients and matched healthy controls

2008 ◽  
Vol 31 (6) ◽  
pp. 319 ◽  
Author(s):  
Anita A Thambirajah ◽  
Kenna Sleigh ◽  
H. Grant Stiver ◽  
Anthony W Chow
Keyword(s):  
Oxidative Stress ◽  
Heat Shock ◽  
Chronic Fatigue Syndrome ◽  
Mononuclear Cells ◽  
Chronic Fatigue ◽  
Peripheral Blood Mononuclear ◽  
Post Exercise ◽  
Fatigue Syndrome ◽  
Before And After ◽  
Biologic Marker

Purpose: Since physical exertion is known to exacerbate the symptoms of chronic fatigue syndrome (CFS) and metabolic changes and including oxidative stress can modulate heat shock protein (HSP) expression responses, we sought to determine whether HSP expression is altered in CFS patients before and after exercise. Heat shock proteins (HSPs) in peripheral blood mononuclear cells (PBMC) were examined from 6 chronic fatigue syndrome (CFS) patients and 7 controls before and after a standardized treadmill exercise. Basal hsp27 was significantly higher among CFS patients compared to controls, and decreased immediately post-exercise, remaining below basal levels even at 7 days. A similar pattern was observed for HSP60, which gradually decreased in CFS patients but increased in controls post-exercise. These findings suggest an abnormal adaptive response to oxidative stress in CFS, and raise the possibility that HSP profiling may provide a more objective biologic marker for this illness. Methods: HSP27, HSP60, HSP70 and HSP90 expression from 6 CFS patients and 7 age- and sex-matched controls were examined by western blot analysis of peripheral blood mononuclear cells immediately before, after, and at 1 day and 7 days following a standardized treadmill exercise. Results: Basal HSP27 was higher among CFS patients than in controls (0.54 ± 0.13 vs. 0.19 ± 0.06, mean ± SEM; P < 0.01). In addition, these levels in CFS patients decreased immediately post-exercise (0.25 ± 0.09; P < 0.05) and remained below basal levels at day 1 post-exercises (0.18 ± 0.05; P < 0.05). P < 0.05). This declining expression of HSP27 during the post-exercise period among CFS patients was confirmed by one-way ANOVA analysis with repeated measures (P < 0.05). In contrast, HSP27 levels remained relatively constant following exercise among control subjects. Similar patterns of declining HSP levels in CFS patients were also observed for HSP60 (0.94 ± 0.40 vs. 1.32 ± 0.46; P < 0.05), and for HSP90 (0.34 ± 0.09 vs. 0.49 ± 0.10; P < 0.05) at day 7 post-exercise compared with basal levels, respectively. In contrast, HSP60 levels in control subjects increased at day 1 (1.09 ± 0.27) and day 7 (1.24 ± 0.50) post-exercise compared to corresponding levels immediately post-exercise (0.55 ± 0.06) (P < 0.05, respectively). Conclusion: These preliminary findings suggest an abnormal or defective adaptive response to oxidative stress in CFS, and raise the possibility that HSP profiling may provide a more objective biologic marker for this illness.

Specific correlations between muscle oxidative stress and chronic fatigue syndrome: a working hypothesis

2007 ◽  
Vol 28 (6) ◽  
pp. 355-362 ◽  
Author(s):  
Stefania Fulle ◽  
Tiziana Pietrangelo ◽  
Rosa Mancinelli ◽  
Raoul Saggini ◽  
Giorgio Fanò
Keyword(s):  
Oxidative Stress ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Working Hypothesis ◽  
Fatigue Syndrome
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