scholarly journals Improvement of Depression-Like Behavior and Memory Impairment with the Ethanol Extract of Pleurotus eryngii in Ovariectomized Rats

2013 ◽  
Vol 36 (12) ◽  
pp. 1990-1995 ◽  
Author(s):  
Akira Minami ◽  
Hiroshi Matsushita ◽  
Yuuki Horii ◽  
Daisuke Ieno ◽  
Yukino Matsuda ◽  
...  
Keyword(s):  
Memory Impairment ◽  
Ethanol Extract ◽  
Pleurotus Eryngii ◽  
Ovariectomized Rats

scholarly journals Hwangryunhaedok-Tang Exerts Neuropreventive Effect on Memory Impairment by Reducing Cholinergic System Dysfunction and Inflammatory Response in a Vascular Dementia Rat Model

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 343 ◽  
Author(s):  
Eunjin Sohn ◽  
Yu Kim ◽  
Hye-Sun Lim ◽  
Bu-Yeo Kim ◽  
Soo-Jin Jeong
Keyword(s):  
Vascular Dementia ◽  
Rat Model ◽  
Memory Impairment ◽  
Neuronal Damage ◽  
Inflammatory Diseases ◽  
Ethanol Extract ◽  
Mitogen Activated Protein Kinase ◽  
Therapeutic Effects ◽  
Sprague Dawley ◽  
Cholinergic Dysfunction

Hwangryunhaedok-tang (HRT) is a traditional oriental herbal formula used in Asian countries for treating inflammatory diseases and controlling fever. Our present study aimed to determine whether HRT has therapeutic effects for patients with vascular dementia (VaD) using a bilateral common carotid artery occlusion (BCCAO) rat model and assessing spatial memory impairment and activation of neuroinflammation. BCCAO was performed in male Sprague Dawley rats to induce VaD, and oral HRT was administered daily for 30 d. Our data showed that HRT ameliorated BCCAO-induced memory and cognitive impairment in behavioral tests. In addition, HRT reversed cholinergic dysfunction and neuronal damage in the hippocampus of BCCAO rats. Furthermore, HRT attenuated microglial activation and reduced the phosphorylation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase (JNK) induced by BCCAO. Simultaneous high-performance liquid chromatography analysis of HRT using index compounds from the herbal composition revealed that both HRT ethanol extract and commercial HRT granules primarily comprise geniposide, baicalin, and berberine. Our study showed that HRT administration resulted in the prevention of neuronal injury induced by BCCAO through improvement of cholinergic dysfunction and inhibition of neuroinflammatory responses, suggesting that HRT may have potential as a treatment for VaD.

scholarly journals WS-5 Extract of Curcuma longa, Chaenomeles sinensis, and Zingiber officinale Contains Anti-AChE Compounds and Improves β-Amyloid-Induced Memory Impairment in Mice

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Ju Eun Kim ◽  
Abinash Chandra Shrestha ◽  
Hyo Shin Kim ◽  
Ha Neul Ham ◽  
Jun Hyeong Kim ◽  
...  
Keyword(s):  
Memory Impairment ◽  
Antioxidant Activities ◽  
Curcuma Longa ◽  
Senile Plaques ◽  
Total Antioxidant Status ◽  
Ethanol Extract ◽  
Zingiber Officinale ◽  
Chaenomeles Sinensis

Alzheimer's disease (AD) is linked to an extensive neuron loss via accumulation of amyloid-beta (Aβ) as senile plaques associated with reactive astrocytes and microglial activation in the brain. The objective of this study was to assess the therapeutic effect of WS-5 ethanol extract in vitro and in vivo against Aβ-induced AD in mice and to identify the extract’s active constituents. In the present study, WS-5 exerted a significant inhibitory effect on acetylcholinesterase (AChE). Analysis by transmission electron microscopy (TEM) revealed that WS-5 prevented Aβ oligomerization via inhibition of Aβ1-42 aggregation. Evaluation of antioxidant activities using 1, 1-diphenyl-2-picrylhydrazyl (DPPH) demonstrated that WS-5 possessed a high antioxidant activity, which was confirmed by measuring the total antioxidant status (TAS). Furthermore, the anti-inflammatory properties of WS-5 were examined using lipopolysaccharide-stimulated BV-2 microglial cells. WS-5 significantly inhibited the lipopolysaccharide–induced production of nitric oxide and two proinflammatory cytokines, TNF-α and IL-6. The memory impairment in mice with Aβ-induced AD was studied using the Morris water maze and passive avoidance test. Immunohistochemistry was performed to monitor pathological changes in the hippocampus and cortex region of the mouse brain. The animal study showed that WS-5 (250 mg/kg) treatment improved learning and suppressed memory impairment as well as reduced Aβ plaque accumulation in Aβ-induced AD. HPLC analysis identified the extract’s active compounds that exert anti-AChE activity. In summary, our findings suggest that WS-5 could be applied as a natural product therapy with a focus on neuroinflammation-related neurodegenerative disorders.

scholarly journals Genistein Improves 3-NPA-Induced Memory Impairment in Ovariectomized Rats: Impact of Its Antioxidant, Anti-Inflammatory and Acetylcholinesterase Modulatory Properties

PLoS ONE ◽  
2015 ◽  
Vol 10 (2) ◽  
pp. e0117223 ◽  
Author(s):  
Esther T. Menze ◽  
Ahmed Esmat ◽  
Mariane G. Tadros ◽  
Ashraf B. Abdel-Naim ◽  
Amani E. Khalifa
Keyword(s):  
Memory Impairment ◽  
Ovariectomized Rats ◽  
Anti Inflammatory

scholarly journals Effect of Achillea millefolium aqueous extract on memory deficit and anxiety caused by stroke in ovariectomized rats

2019 ◽  
Vol 8 (2) ◽  
pp. 153-159 ◽  
Author(s):  
Gila Pirzad Jahromi ◽  
Esmail Imani ◽  
Mohammad Nasehi ◽  
Alireza Shahriari
Keyword(s):  
Cerebral Ischemia ◽  
Aqueous Extract ◽  
Memory Impairment ◽  
Develop Breast Cancer ◽  
Ovariectomized Rats ◽  
Menopausal Woman ◽  
Artery Ligation ◽  
Plus Maze ◽  
Female Wistar Rats ◽  
Restoration Effect

Introduction: Some studies indicated that the decrease of estrogen level in menopausal woman results in increasing the risk of stroke. Although estrogen is a neuroprotective factor, high consumption of this compound may develop breast cancer and endometriosis. The present study investigated the effect of Achilles millefolium extract, containing estrogenlike compounds, on memory impairment and anxiogenic-like behaviors caused by cerebral ischemia in ovariectomized rats. Methods: Permanent middle cerebral artery ligation was performed, as a model for studying postmenopausal condition, in 48 female Wistar rats weighing 200-250 g. The aqueous extract of A. millefolium was prepared and gavaged for 4 weeks after inducing cerebral ischemia. Memory and anxiety-like behavior assessments were evaluated by step-through and elevated plus maze apparatus, respectively. Result: According to the results, cerebral ischemia in ovariectomized rats induced amnesia and anxiogenic-like behaviors which were restored by 7 mg/kg of A. millefolium aqueous extract. Furthermore, inactivation of estrogen receptors (ERs) by tamoxifen (100 µg/kg, intraperitoneally) blocked the restoration effect of A. millefolium on behaviors induced by cerebral ischemia. Conclusion: It could be concluded that, oral administration of A. millefolium extract is able to restore memory impairment and anxiogenic-like behaviors induced by ischemia via ERs in ovariectomized rat.

scholarly journals Effects of Ficus umbellata (Moraceae) Aqueous Extract and 7-Methoxycoumarin on Scopolamine-Induced Spatial Memory Impairment in Ovariectomized Wistar Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Stéphane Zingue ◽  
Harquin Simplice Foyet ◽  
Sefirin Djiogue ◽  
Yannick Ezo’o Ezo’o ◽  
Hervé Hervé Ngatanko Abaïssou ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Aqueous Extract ◽  
Memory Impairment ◽  
Wistar Rats ◽  
Reference Memory ◽  
Ovariectomized Rats ◽  
Estradiol Valerate ◽  
Memory Errors ◽  
Neuroprotective Effects ◽  
Before And After

The present work was undertaken to evaluate the ability of F. umbellata aqueous extract and its major component 7-methoxycoumarin (MC) to improve scopolamine-induced spatial memory impairment in ovariectomized Wistar rats. For this to be done, 10 sham-operated and 30 postmenopausal-like rats were randomly distributed in eight groups (n=5) and treated with distilled water (2 mL/250 g), estradiol valerate (1 mg/kg BW), piracetam (1.5 mg/kg BW), F. umbellata aqueous extract (50 and 200 mg/kg BW), or MC (1 mg/kg BW) for 21 consecutive days. Before and after the memory impairment with scopolamine (2 mg/kg BW), animals underwent behavioral evaluations on Y- and radial mazes. As results, age and ovariectomy did not induce significant changes in the reference memory errors. While age decreased working memory errors, ovariectomy increased it. The MC as well as F. umbellata extract significantly increased (p<0.01) the percentage of spontaneous alternation and decreased (p<0.001) working and spatial reference memory errors and anxiety parameters (rearing and grooming) in ovariectomized rats. MC significantly reduced (p<0.05) the MDA level, but resulted in an increase in GSH level in brain homogenates. These results suggest that MC is endowed with neuroprotective effects and could account for the neuroprotective effects of F. umbellata in rats.

scholarly journals Spatial Memory Impairment Is Associated with Hippocampal Insulin Signals in Ovariectomized Rats

PLoS ONE ◽  
2014 ◽  
Vol 9 (8) ◽  
pp. e104450 ◽  
Author(s):  
Fang Wang ◽  
Yan-Feng Song ◽  
Jie Yin ◽  
Zi-Hua Liu ◽  
Xiao-Dan Mo ◽  
...  
Keyword(s):  
Spatial Memory ◽  
Memory Impairment ◽  
Ovariectomized Rats

Effect of the ethanol extract ofPleurotus eryngiion bone metabolism in ovariectomized rats

Climacteric ◽  
2014 ◽  
Vol 17 (4) ◽  
pp. 492-499 ◽  
Author(s):  
Y. Ohyama ◽  
H. Matsushita ◽  
A. Minami ◽  
H. Kanazawa ◽  
T. Suzuki ◽  
...  
Keyword(s):  
Bone Metabolism ◽  
Ethanol Extract ◽  
Ovariectomized Rats
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