scholarly journals Pericyte-Coverage of Human Tumor Vasculature and Nanoparticle Permeability

2012 ◽  
Vol 35 (5) ◽  
pp. 761-766 ◽  
Author(s):  
Liuzhe Zhang ◽  
Hiroshi Nishihara ◽  
Mitsunobu R Kano
Keyword(s):  
Human Tumor ◽  
Tumor Vasculature ◽  
Pericyte Coverage

scholarly journals Exercise during preoperative therapy increases tumor vascularity in pancreatic tumor patients

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Claudia Alvarez Florez Bedoya ◽  
Ana Carolina Ferreira Cardoso ◽  
Nathan Parker ◽  
An Ngo-Huang ◽  
Maria Q. Petzel ◽  
...  
Keyword(s):  
Vascular Remodeling ◽  
Vascular Function ◽  
Human Tumor ◽  
Tumor Vasculature ◽  
Ductal Adenocarcinoma ◽  
Tumor Vascularity ◽  
Exercise Induced ◽  
First Time ◽  
Chemotherapy Efficacy ◽  
Exercise In Humans

Abstract The efficacy of chemotherapy is reduced by dysfunctional tumor vasculature, which may limit chemotherapy delivery to tumors. Preclinical studies have shown that moderate aerobic exercise improves tumor vascular function and increases chemotherapy efficacy in mouse models, but the effect of exercise on human tumor vasculature has not yet been determined. Here, we demonstrate that exercise remodels the tumor vasculature, accelerates the regression, and delays the regrowth of pancreatic ductal adenocarcinoma in a patient-derived xenograft mouse model treated with gemcitabine. By evaluating pancreatic adenocarcinoma specimens from patients treated with preoperative chemotherapy or chemoradiation therapy, we also demonstrate for the first time that tumor vascular remodeling occurs in association with exercise in humans. Future studies will evaluate whether exercise-induced vascular remodeling improves gemcitabine or other chemotherapy efficacy in patients, as this study evaluated only changes in tumor vascular structure.

scholarly journals Specific Occlusion of Murine and Human Tumor Vasculature by VCAM-1–Targeted Recombinant Fusion Proteins

2005 ◽  
Vol 97 (10) ◽  
pp. 733-747 ◽  
Author(s):  
Ariane Dienst ◽  
Andrea Grunow ◽  
Maike Unruh ◽  
Berit Rabausch ◽  
Jacques E. Nör ◽  
...  
Keyword(s):  
Fusion Proteins ◽  
Human Tumor ◽  
Tumor Vasculature ◽  
Recombinant Fusion Proteins

scholarly journals Up-regulation of Delta-like 4 Ligand in Human Tumor Vasculature and the Role of Basal Expression in Endothelial Cell Function

2005 ◽  
Vol 65 (19) ◽  
pp. 8690-8697 ◽  
Author(s):  
Nilay S. Patel ◽  
Ji-Liang Li ◽  
Daniele Generali ◽  
Richard Poulsom ◽  
David W. Cranston ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Cell Function ◽  
Human Tumor ◽  
Tumor Vasculature ◽  
Endothelial Cell Function ◽  
Basal Expression

Effect of transplantation of pro-angiogenic monocytes to pancreatic cancer-bearing mice on resistance to chemotherapy/radiotherapy.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 212-212
Author(s):  
Y. Mizukami ◽  
T. Kawamoto ◽  
Y. Sugiyama ◽  
J. Sasajima ◽  
K. Koizumi ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Mononuclear Cells ◽  
Tumor Vasculature ◽  
Chemotherapeutic Agents ◽  
Genetically Engineered ◽  
Gene Expressions ◽  
Anticancer Drug Delivery ◽  
Pericyte Coverage ◽  
Genetically Engineered Mice ◽  
Endothelial Growth Medium

212 Background: Hypoxic tumors are usually resistant to conventional chemotherapy and radiotherapies, which typically target actively dividing cells. The tumor vasculatures are unorganized and lack adequate pericyte coverage, which compromises delivery of drugs to tumors. How best to normalize the aberrant tumor vasculature to maximize anticancer drug delivery comprises an area of intensive investigation. Methods: We tested out hypothesize that bone marrow (BM) cells may be able to restore appropriate vessel function in tumor vasculature using nude mice bearing pancreatic cancer xenografts and genetically engineered mice that develop pancreatic adenocarcinoma. Results: Culturing BM mononuclear cells with endothelial growth medium resulted in the early outgrowth of spindle-shaped attached monocytic cells expressing CD11b/CXCR4 with a significant vessel stabilizing activity. Intravenous administration of these cultured pro- angiogenic cells into mice bearing pancreatic cancer significantly reduced areas of hypoxia without enhancing tumor growth. The resulting vasculature structurally mimicked normal vessels with intensive pericyte coverage. Consistent with a marked reduction in gene expressions involved in drug resistance such as MDR1 and ABCG2 in monocytes-injected tumors, a combination of the transplantation and chemotherapeutic agents reduced tumor size and significantly increased areas of necrosis as compared to chemotherapy alone. Conclusions: Our findings offer an alternate approach to improve delivery and efficacy of anticancer drugs to hypoxic tumors through a remodeling of the abnormal tumor vessels. No significant financial relationships to disclose.

scholarly journals A Novel Model for Evaluating Therapies Targeting Human Tumor Vasculature and Human Cancer Stem–like Cells

2013 ◽  
Vol 73 (12) ◽  
pp. 3555-3565 ◽  
Author(s):  
Daniela Burgos-Ojeda ◽  
Karen McLean ◽  
Shoumei Bai ◽  
Heather Pulaski ◽  
Yusong Gong ◽  
...  
Keyword(s):  
Human Cancer ◽  
Human Tumor ◽  
Tumor Vasculature ◽  
Novel Model
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