scholarly journals Characteristics of Diabetic Osteopenia in KK-Ay Diabetic Mice

2012 ◽  
Vol 35 (3) ◽  
pp. 438-443 ◽  
Author(s):  
Satoshi Takagi ◽  
Toshihiro Miura ◽  
Takenori Yamashita ◽  
Naoki Ando ◽  
Haruka Nakao ◽  
...  
Keyword(s):  
Diabetic Mice ◽  
Diabetic Osteopenia

Histomorphometric analysis of diabetic osteopenia in streptozotocin-induced diabetic mice: A possible role of oxidative stress

Bone ◽  
2007 ◽  
Vol 40 (5) ◽  
pp. 1408-1414 ◽  
Author(s):  
Yasuhiro Hamada ◽  
Sohei Kitazawa ◽  
Riko Kitazawa ◽  
Hideki Fujii ◽  
Masato Kasuga ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Diabetic Mice ◽  
Histomorphometric Analysis ◽  
Diabetic Osteopenia

Anti-Diabetic Activity of a Mineraloid Isolate, in vitro and in Genetically Diabetic Mice

2011 ◽  
Vol 81 (1) ◽  
pp. 34-42 ◽  
Author(s):  
Joel Deneau ◽  
Taufeeq Ahmed ◽  
Roger Blotsky ◽  
Krzysztof Bojanowski
Keyword(s):  
Dna Microarrays ◽  
Human Fibroblasts ◽  
Diabetic Animal ◽  
In Vitro Tests ◽  
Diabetic Mice ◽  
Fossil Material ◽  
Expression Of Genes ◽  
Enhanced Expression ◽  
Genetically Diabetic Mice

Type II diabetes is a metabolic disease mediated through multiple molecular pathways. Here, we report anti-diabetic effect of a standardized isolate from a fossil material - a mineraloid leonardite - in in vitro tests and in genetically diabetic mice. The mineraloid isolate stimulated mitochondrial metabolism in human fibroblasts and this stimulation correlated with enhanced expression of genes coding for mitochondrial proteins such as ATP synthases and ribosomal protein precursors, as measured by DNA microarrays. In the diabetic animal model, consumption of the Totala isolate resulted in decreased weight gain, blood glucose, and glycated hemoglobin. To our best knowledge, this is the first description ever of a fossil material having anti-diabetic activity in pre-clinical models.

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