Identification of Enzymes Responsible for the N-Oxidation of Darexaban Glucuronide, the Pharmacologically Active Metabolite of Darexaban, and the Glucuronidation of Darexaban N-Oxides in Human Liver Microsomes

2012 ◽  
Vol 35 (3) ◽  
pp. 413-421 ◽  
Author(s):  
Toshifumi Shiraga ◽  
Kanako Yajima ◽  
Takuya Teragaki ◽  
Katsuhiro Suzuki ◽  
Tadashi Hashimoto ◽  
...  
Keyword(s):  
Active Metabolite ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Pharmacologically Active

Selective Inhibition of Cytochrome P450 2D6 by Sarpogrelate and Its Active Metabolite, M-1, in Human Liver Microsomes

2013 ◽  
Vol 42 (1) ◽  
pp. 33-39 ◽  
Author(s):  
Doo-Yeoun Cho ◽  
Soo Hyeon Bae ◽  
Joeng Kee Lee ◽  
Yang Weon Kim ◽  
Bom-Taeck Kim ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Active Metabolite ◽  
Human Liver ◽  
Liver Microsomes ◽  
Selective Inhibition ◽  
Human Liver Microsomes ◽  
Cytochrome P450 2D6 ◽  
P450 2D6

In vitro hepatic conversion of the anticancer agent nemorubicin to its active metabolite PNU-159682 in mice, rats and dogs: A comparison with human liver microsomes

2008 ◽  
Vol 76 (6) ◽  
pp. 784-795 ◽  
Author(s):  
Luigi Quintieri ◽  
Marianna Fantin ◽  
Pietro Palatini ◽  
Sara De Martin ◽  
Antonio Rosato ◽  
...  
Keyword(s):  
Active Metabolite ◽  
Human Liver ◽  
Anticancer Agent ◽  
Liver Microsomes ◽  
Human Liver Microsomes

Thein vitro metabolism of desglymidodrine, an active metabolite of prodrug midodrine by human liver microsomes

2004 ◽  
Vol 29 (3) ◽  
pp. 179-186 ◽  
Author(s):  
Masayuki Akimoto ◽  
Izumi Iida ◽  
Hiroki Itoga ◽  
Atsunori Miyata ◽  
Shizuko Kawahara ◽  
...  
Keyword(s):  
Active Metabolite ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes
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