scholarly journals Site-Specific Chemical Modification of Human Serum Albumin with Polyethylene Glycol Prolongs Half-life and Improves Intravascular Retention in Mice

2012 ◽  
Vol 35 (3) ◽  
pp. 280-288 ◽  
Author(s):  
Ting Zhao ◽  
Yan-Na Cheng ◽  
Hai-Ning Tan ◽  
Jin-Feng Liu ◽  
Huan-Li Xu ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Human Serum Albumin ◽  
Serum Albumin ◽  
Chemical Modification ◽  
Human Serum ◽  
Half Life ◽  
Specific Chemical ◽  
Site Specific ◽  
Specific Chemical Modification

Comparative studies of the serum half-life extension of a protein via site-specific conjugation to a species-matched or -mismatched albumin

2018 ◽  
Vol 6 (8) ◽  
pp. 2092-2100 ◽  
Author(s):  
Byungseop Yang ◽  
Jong Chul Kim ◽  
Jihyoun Seong ◽  
Giyoong Tae ◽  
Inchan Kwon
Keyword(s):  
Human Serum Albumin ◽  
Serum Albumin ◽  
Human Serum ◽  
Comparative Studies ◽  
Half Life ◽  
Therapeutic Proteins ◽  
Life Extension ◽  
Site Specific

Human serum albumin (HSA) has been investigated as a serum half-life extender of therapeutic proteins thanks to its unusually long serum half-life.

IL-4 Analogues with Site-Specific Chemical Modification at Position 121 Inhibit IL-4 and IL-13 Biological Activities

2013 ◽  
Vol 25 (1) ◽  
pp. 52-62 ◽  
Author(s):  
Viswanadham Duppatla ◽  
Maja Gjorgjevikj ◽  
Werner Schmitz ◽  
Heike M. Hermanns ◽  
Carmen M. Schäfer ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Biological Activities ◽  
Specific Chemical ◽  
Site Specific ◽  
Specific Chemical Modification

scholarly journals Controlling activation of the RNA-dependent protein kinase by siRNAs using site-specific chemical modification

2006 ◽  
Vol 34 (17) ◽  
pp. 4900-4911 ◽  
Author(s):  
Sujiet Puthenveetil ◽  
Landon Whitby ◽  
Jin Ren ◽  
Kevin Kelnar ◽  
Joseph F. Krebs ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Chemical Modification ◽  
Dependent Protein Kinase ◽  
Specific Chemical ◽  
Site Specific ◽  
Specific Chemical Modification ◽  
Dependent Protein
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