scholarly journals Beta-Cryptoxanthin, Plentiful in Japanese Mandarin Orange, Prevents Age-Related Cognitive Dysfunction and Oxidative Damage in Senescence-Accelerated Mouse Brain

2011 ◽  
Vol 34 (3) ◽  
pp. 311-317 ◽  
Author(s):  
Keiko Unno ◽  
Minoru Sugiura ◽  
Kazunori Ogawa ◽  
Fumiyo Takabayashi ◽  
Masateru Toda ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Cognitive Dysfunction ◽  
Mouse Brain ◽  
Age Related ◽  
Mandarin Orange ◽  
Senescence Accelerated Mouse

scholarly journals Age-Related Alterations in the Expression of Glial Cell Line-Derived Neurotrophic Factor in the Senescence-Accelerated Mouse Brain

2003 ◽  
Vol 92 (1) ◽  
pp. 28-34 ◽  
Author(s):  
Hiroyuki Miyazaki ◽  
Yasunobu Okuma ◽  
Jun Nomura ◽  
Kazuo Nagashima ◽  
Yasuyuki Nomura
Keyword(s):  
Cell Line ◽  
Glial Cell ◽  
Mouse Brain ◽  
Neurotrophic Factor ◽  
Age Related ◽  
Senescence Accelerated Mouse

Age-Related Changes in Energy Production in Fresh Senescence-Accelerated Mouse Brain Slices as Revealed by Positron Autoradiography

2001 ◽  
Vol 12 (2) ◽  
pp. 78-84 ◽  
Author(s):  
Naoto Omata ◽  
Tetsuhito Murata ◽  
Yasuhisa Fujibayashi ◽  
Atsuo Waki ◽  
Norihiro Sadato ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Energy Production ◽  
Brain Slices ◽  
Age Related ◽  
Senescence Accelerated Mouse ◽  
Age Related Changes

Age-related changes in barrier function in mouse brain

1997 ◽  
Vol 25 (3) ◽  
pp. 321-331 ◽  
Author(s):  
Masaki Ueno ◽  
Ichiro Akiguchi ◽  
Masanori Hosokawa ◽  
Masahiko Shinnou ◽  
Haruhiko Sakamoto ◽  
...  
Keyword(s):  
Mouse Brain ◽  
Barrier Function ◽  
Age Related ◽  
Age Related Changes

Oxidative damage causes formation of lipofuscin-like substances in the hippocampus of the senescence-accelerated mouse after kainate treatment

2002 ◽  
Vol 131 (1-2) ◽  
pp. 211-220 ◽  
Author(s):  
Hyoung-Chun Kim ◽  
Guoying Bing ◽  
Wang-Kee Jhoo ◽  
Won-Ki Kim ◽  
Eun-Joo Shin ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Senescence Accelerated Mouse

scholarly journals Lifelong Calorie Restriction Alleviates Age-Related Oxidative Damage in Peripheral Nerves

2010 ◽  
Vol 13 (1) ◽  
pp. 65-74 ◽  
Author(s):  
Katherine Opalach ◽  
Sunitha Rangaraju ◽  
Irina Madorsky ◽  
Christiaan Leeuwenburgh ◽  
Lucia Notterpek
Keyword(s):  
Oxidative Damage ◽  
Calorie Restriction ◽  
Peripheral Nerves ◽  
Age Related

scholarly journals Molecular Mechanisms Responsible for Increased Vulnerability of the Ageing Oocyte to Oxidative Damage

2017 ◽  
Vol 2017 ◽  
pp. 1-22 ◽  
Author(s):  
Bettina P. Mihalas ◽  
Kate A. Redgrove ◽  
Eileen A. McLaughlin ◽  
Brett Nixon
Keyword(s):  
Oxidative Damage ◽  
Molecular Mechanisms ◽  
Spindle Assembly Checkpoint ◽  
Assisted Reproductive Technologies ◽  
Reproductive Technologies ◽  
Oocyte Quality ◽  
Protein Repair ◽  
Protective Mechanisms ◽  
Pronounced Increase ◽  
Age Related

In their midthirties, women experience a decline in fertility, coupled to a pronounced increase in the risk of aneuploidy, miscarriage, and birth defects. Although the aetiology of such pathologies are complex, a causative relationship between the age-related decline in oocyte quality and oxidative stress (OS) is now well established. What remains less certain are the molecular mechanisms governing the increased vulnerability of the aged oocyte to oxidative damage. In this review, we explore the reduced capacity of the ageing oocyte to mitigate macromolecular damage arising from oxidative insults and highlight the dramatic consequences for oocyte quality and female fertility. Indeed, while oocytes are typically endowed with a comprehensive suite of molecular mechanisms to moderate oxidative damage and thus ensure the fidelity of the germline, there is increasing recognition that the efficacy of such protective mechanisms undergoes an age-related decline. For instance, impaired reactive oxygen species metabolism, decreased DNA repair, reduced sensitivity of the spindle assembly checkpoint, and decreased capacity for protein repair and degradation collectively render the aged oocyte acutely vulnerable to OS and limits their capacity to recover from exposure to such insults. We also highlight the inadequacies of our current armoury of assisted reproductive technologies to combat age-related female infertility, emphasising the need for further research into mechanisms underpinning the functional deterioration of the ageing oocyte.

scholarly journals Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction

Cell ◽  
2010 ◽  
Vol 143 (5) ◽  
pp. 802-812 ◽  
Author(s):  
Shinichi Someya ◽  
Wei Yu ◽  
William C. Hallows ◽  
Jinze Xu ◽  
James M. Vann ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Oxidative Damage ◽  
Caloric Restriction ◽  
Age Related ◽  
Age Related Hearing Loss
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