scholarly journals Fibroblast Growth Factor 19 Treatment Ameliorates Disruption of Hepatic Lipid Metabolism in Farnesoid X Receptor (Fxr)-Null Mice

2011 ◽  
Vol 34 (12) ◽  
pp. 1885-1889 ◽  
Author(s):  
Masaaki Miyata ◽  
Yumi Sakaida ◽  
Hitomi Matsuzawa ◽  
Kouichi Yoshinari ◽  
Yasushi Yamazoe
Keyword(s):  
Lipid Metabolism ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Farnesoid X Receptor ◽  
Fibroblast Growth ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Fibroblast Growth Factor 19

scholarly journals Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States

2007 ◽  
Vol 5 (6) ◽  
pp. 426-437 ◽  
Author(s):  
Michael K. Badman ◽  
Pavlos Pissios ◽  
Adam R. Kennedy ◽  
George Koukos ◽  
Jeffrey S. Flier ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid

scholarly journals Dual actions of fibroblast growth factor 19 on lipid metabolism

2012 ◽  
Vol 54 (2) ◽  
pp. 325-332 ◽  
Author(s):  
Xinle Wu ◽  
Hongfei Ge ◽  
Hélène Baribault ◽  
Jamila Gupte ◽  
Jennifer Weiszmann ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor 19

scholarly journals Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids

2013 ◽  
Vol 304 (10) ◽  
pp. G940-G948 ◽  
Author(s):  
Justine H. Zhang ◽  
Jonathan D. Nolan ◽  
Sarah L. Kennie ◽  
Ian M. Johnston ◽  
Tracy Dew ◽  
...  
Keyword(s):  
Bile Acid ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Culture Fluid ◽  
Farnesoid X Receptor ◽  
Transcript Expression ◽  
Fibroblast Growth ◽  
Primary Explants ◽  
Fgf19 Expression ◽  
Fibroblast Growth Factor 19

Fibroblast growth factor 19 (FGF19) is proposed to be a negative feedback regulator of hepatic bile acid (BA) synthesis. We aimed to clarify the distribution of FGF19 expression in human intestine and to investigate induction in a novel explant system. Ileal and colonic mucosal biopsies were obtained at endoscopy and analyzed for FGF19 transcript expression. Primary explants were incubated with physiological concentrations of various BA for up to 6 h, and expression of FGF19 and other genes was determined. FGF19 transcripts were detected in ileum but were unquantifiable in colon. No loss of FGF19 mRNA occurred as a consequence of the explant system. Ileal FGF19 transcript expression was induced 350-fold by 50 μM chenodeoxycholate (CDCA, n = 24, P < 0.0001) and 161-fold by 50 μM glycochenodeoxycholate (GCDCA, n = 12, P = 0.0005). The responses of other genes to CDCA or GCDCA (50 μM) were smaller: median increases of ileal bile acid binding protein, organic solute transporter-α and -β, and short heterodimer partner were 2.4- to 4.0-fold; apical membrane sodium bile acid transporter and farnesoid X receptor (FXR) showed little change. The EC50 for FGF19 transcript induction by CDCA was 20 μM. FGF19 protein concentrations were significantly higher in the culture fluid from BA-stimulated explants. FGF19 induction with cholate was 81% of that found with CDCA, but deoxycholate (40%) and lithocholate (4%) were significantly less potent. The synthetic FXR agonist obeticholic acid was much more potent than CDCA with a 70-fold FGF19 stimulation at 1 μM. We concluded that FGF19 expression in human ileum is very highly responsive to BA. Changes in FGF19 induction are a potential mechanism involved in disorders of BA homeostasis.

scholarly journals Corrigendum to ‘Fibroblast growth factor 19 modulates intestinal microbiota and inflammation in presence of farnesoid x receptor’

EBioMedicine ◽  
2020 ◽  
Vol 57 ◽  
pp. 102873
Author(s):  
Raffaella Maria Gadaleta ◽  
Oihane Garcia-Irigoyen ◽  
Marica Cariello ◽  
Natasha Scialpi ◽  
Claudia Peres ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Intestinal Microbiota ◽  
Farnesoid X Receptor ◽  
Fibroblast Growth ◽  
Fibroblast Growth Factor 19
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