scholarly journals Cladribine Enhances Apoptotic Cell Death in Lung Carcinoma Cells Over-Expressing DNase γ

2011 ◽  
Vol 34 (7) ◽  
pp. 1001-1004
Author(s):  
Akemi Hayakawa ◽  
Haruhiko Suzuki ◽  
Yuzuru Kamei ◽  
Sei-ichi Tanuma ◽  
Junji Magae
Keyword(s):  
Cell Death ◽  
Lung Carcinoma ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Carcinoma Cells ◽  
Dnase Γ ◽  
Lung Carcinoma Cells

scholarly journals Caspase Cascade Activation During Apoptotic Cell Death of Human Lung Carcinoma Cells A549 Induced by Marine Sponge Callyspongia aerizusa

2021 ◽  
Vol Volume 15 ◽  
pp. 1357-1368
Author(s):  
Yuni Elsa Hadisaputri ◽  
Rheza Andika ◽  
Iyan Sopyan ◽  
Ade Zuhrotun ◽  
Rani Maharani ◽  
...  
Keyword(s):  
Cell Death ◽  
Lung Carcinoma ◽  
Marine Sponge ◽  
Human Lung ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Carcinoma Cells ◽  
Lung Carcinoma Cells ◽  
Human Lung Carcinoma ◽  
Caspase Cascade

Licochalcone A induces apoptotic cell death via JNK/p38 activation in human nasopharyngeal carcinoma cells

2019 ◽  
Vol 34 (7) ◽  
pp. 853-860 ◽  
Author(s):  
Chun‐Yi Chuang ◽  
Cheng‐Ming Tang ◽  
Hsin‐Yu Ho ◽  
Chung‐Han Hsin ◽  
Chia‐Jui Weng ◽  
...  
Keyword(s):  
Cell Death ◽  
Nasopharyngeal Carcinoma ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Carcinoma Cells ◽  
Licochalcone A ◽  
Human Nasopharyngeal Carcinoma

scholarly journals Mechanism of apoptotic cell death of human gastric carcinoma cells mediated by transforming growth factor β

1997 ◽  
Vol 324 (3) ◽  
pp. 777-782 ◽  
Author(s):  
Shigeki OHTA ◽  
Kazuyoshi YANAGIHARA ◽  
Kiyoshi NAGATA
Keyword(s):  
Cell Death ◽  
Gastric Carcinoma ◽  
Expression Vector ◽  
Transforming Growth Factor ◽  
Apoptotic Cell ◽  
Apoptotic Cell Death ◽  
Carcinoma Cells ◽  
Human Gastric Carcinoma ◽  
Human Gastric Carcinoma Cells ◽  
Tgf Β1

Human gastric carcinoma cell line HSC-39 has been shown to undergo apoptotic cell death in response to treatment with transforming growth factor β1 (TGF-β1). To understand better the cell death mechanism in this TGF-β1-mediated apoptosis, we investigated the effect of the expression of TGF-β-stimulated clone 22 (TSC-22) on cell death events. TGF-β1 induced TSC-22 gene expression in HSC-39 cells only when the cells had previously been adapted to the serum-free culture conditions required to undergo TGF-β1-mediated apoptosis. HSC-39 cells transfected with a TSC-22 expression vector showed a significant decrease in cell viability compared with those transfected with a control vector. The cellular events characteristic of apoptosis, chromatin condensation and DNA fragmentation were observed only in cells transfected with a TSC-22 expression vector. On immunostaining of the transfected cells, almost every cell that expressed TSC-22 tagged with influenza virus haemagglutinin exhibited the morphology of an apoptotic cell. Partial protection from the cell death effect of TGF-β1 on HSC-39 cells was observed when cells were treated with acetyl-l-aspartyl-l-glutamyl-l-valyl-l-aspart-1-al (Ac-DEVD-CHO, an inhibitor specific for CPP32-type protease). Protection against cell death by the transfection of a TSC-22 expression vector was also offered by Ac-DEVD-CHO addition. These results suggest that TSC-22 elicits the apoptotic cell death of human gastric carcinoma cells through the activation of CPP32-like protease and mediates the TGF-β1 signalling pathway to apoptosis.

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