scholarly journals Doxycycline Attenuates Isoproterenol-Induced Myocardial Fibrosis and Matrix Metalloproteinase Activity in Rats

2009 ◽  
Vol 32 (10) ◽  
pp. 1678-1682 ◽  
Author(s):  
Yasutomo Hori ◽  
Shoh-ichi Kunihiro ◽  
Shingo Sato ◽  
Kazuki Yoshioka ◽  
Yukio Hara ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Myocardial Fibrosis ◽  
Metalloproteinase Activity

scholarly journals Long-Term Ethanol Consumption Leadsto Lung Tissue Oxidative Stress and Injury

2010 ◽  
Vol 3 (6) ◽  
pp. 414-420 ◽  
Author(s):  
Subir Kumar Das ◽  
Sukhes Mukherjee
Keyword(s):  
Oxidative Stress ◽  
Body Weight ◽  
Matrix Metalloproteinase ◽  
Lung Tissue ◽  
Ethanol Consumption ◽  
Ethanol Exposure ◽  
Lung Homogenate ◽  
Ethanol Administration ◽  
Metalloproteinase Activity

Background: Alcohol abuse is a systemic disorder. The deleterious health effects of alcohol consumption may result in irreversible organ damage. By contrast, there currently is little evidence for the toxicity of chronic alcohol use on lung tissue. Hence, in this study we investigated long-term effects of ethanol in the lung.Results: Though body weight of rats increased significantly with duration of exposure compared to its initial weight, there was no significant change in relative weight (g/100 g body weight) of lung due to ethanol exposure. The levels of thiobarbituric acid reactive substances (TBARS), nitrite, protein carbonyl, oxidized glutathione (GSS G), redox ratio (GSS G/ GSH ) and GST activity elevated; while reduced glutathione (GSH ) level and activities of glutathione reductase (GR), glutathione peroxidase (GPx), catalase, superoxide dismutase (SOD) and Na+K+ATPase reduced significantly with duration of ethanol exposure in the lung homogenate compared to the control group. Total matrix metalloproteinase activity elevated in the lung homogenate with time of ethanol consumption. Histopathologic examination also demonstrated that severity of lung injury enhanced with duration of ethanol exposure.Methods: 16–18 week-old male albino Wistar strain rats weighing 200–220 g were fed with ethanol (1.6 g/kg body weight/day) up to 36 weeks. At the end of the experimental period, blood samples were collected from reteroorbital plexus to determine blood alcohol concentration and the animals were sacrificed. Various oxidative stress-related biochemical parameters, total matrix metalloproteinase activity and histopathologic examinations of the lung tissues were performed.Conclusions: Results of this study indicate that long-term ethanol administration aggravates systemic and local oxidative stress, which may be associated with lung tissue injury.

Fluorescence imaging to assess the matrix metalloproteinase activity and its inhibitor in vivo

2008 ◽  
Vol 13 (1) ◽  
pp. 011006 ◽  
Author(s):  
Zhihong Zhang ◽  
Jie Yang ◽  
Jinling Lu ◽  
Juqiang Lin ◽  
Shaoqun Zeng ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Fluorescence Imaging ◽  
The Matrix ◽  
Metalloproteinase Activity

Matrix metalloproteinase activity relates to macrophages and plaque complications

1995 ◽  
Vol 115 ◽  
pp. S26
Author(s):  
A.C. van der Wal ◽  
M.M.H. Marijianowski ◽  
C.M. van der Loos ◽  
D.C. Jansen ◽  
V. Everts ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Metalloproteinase Activity

Abstract 172: Lumican-null Mice Are Susceptible to Aging and Isoproterenol-induced Myocardial Fibrosis

2014 ◽  
Vol 115 (suppl_1) ◽  
Author(s):  
Pao-Hsien Chu
Keyword(s):  
Matrix Metalloproteinase ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Myocardial Fibrosis ◽  
Cardiac Remodeling ◽  
Cardiac Fibrosis ◽  
Systolic Function ◽  
Wild Type ◽  
Matrix Metalloproteinase 1 ◽  
Membrane Type

Aims: With aging and stresses, the myocardium undergoes structural remodeling and often leading to fibrosis. Main Methods: To examine whether lumican, one of the class II small leucine-rich proteoglycans, has a role in cardiac remodeling and fibrosis, we analyzed the basic cardiac phenotypes of lumican-null (Lum-/-) mice in both youth and elder, and then used the isoproterenol-induced cardiac fibrosis model to study the roles of extra-cellular matrix and apoptosis in cardiac remodeling. Key Findings: Higher mortality resulted from significantly impaired systolic function, and an increase of atrial natriuretic peptide secreted by the ventricles in response to excessive stretching of myocytes of Lum-/- mice in comparison to wild type littermates. In addition, Lum-/- mice exhibited higher level of TGF-β, collagen I/III, and membrane-type matrix metalloproteinase-1 (MT1-MMP, or MMP-14) during cardiac remodeling. Significance: Our data implicates that the lumican protein plays an important role in the pathogenesis of cardiac fibrosis.

scholarly journals Diabetes Mellitus Enhances Vascular Matrix Metalloproteinase Activity

2001 ◽  
Vol 88 (12) ◽  
pp. 1291-1298 ◽  
Author(s):  
Shiro Uemura ◽  
Hidetsugu Matsushita ◽  
Wei Li ◽  
Alexander J. Glassford ◽  
Tomoko Asagami ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Matrix Metalloproteinase ◽  
Metalloproteinase Activity

scholarly journals Activated Leukocyte Cell Adhesion Molecule (ALCAM/CD166/MEMD), a Novel Actor in Invasive Growth, Controls Matrix Metalloproteinase Activity

2005 ◽  
Vol 65 (19) ◽  
pp. 8801-8808 ◽  
Author(s):  
Pim C. Lunter ◽  
Jeroen W.J. van Kilsdonk ◽  
Hanneke van Beek ◽  
Ine M.H.A. Cornelissen ◽  
Mieke Bergers ◽  
...  
Keyword(s):  
Cell Adhesion ◽  
Matrix Metalloproteinase ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
Invasive Growth ◽  
Growth Controls ◽  
Metalloproteinase Activity

Discovery and development of a type II collagen neoepitope (TIINE) biomarker for matrix metalloproteinase activity: From in vitro to in vivo

2007 ◽  
Vol 361 (1) ◽  
pp. 93-101 ◽  
Author(s):  
O.V. Nemirovskiy ◽  
D.R. Dufield ◽  
T. Sunyer ◽  
P. Aggarwal ◽  
D.J. Welsch ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Metalloproteinase Activity

scholarly journals Matrix Metalloproteinase Activity in the Stromal Cell of Giant Cell Tumor of Bone

2009 ◽  
Vol 1 (1) ◽  
pp. 46-52 ◽  
Author(s):  
Alexander Rabinovich ◽  
Isabella W.Y. Mak ◽  
Robert W. Cowan ◽  
Robert E. Turcotte ◽  
Nigel Colterjohn ◽  
...  
Keyword(s):  
Matrix Metalloproteinase ◽  
Giant Cell Tumor ◽  
Giant Cell ◽  
Stromal Cell ◽  
Cell Tumor ◽  
Metalloproteinase Activity
Sign in / Sign up

Export Citation Format

Share Document