scholarly journals Preparation and Evaluation of Immediate Release Ibuprofen Solid Dispersions Using Polyethylene Glycol 4000

2008 ◽  
Vol 31 (5) ◽  
pp. 939-945 ◽  
Author(s):  
Madhuri Newa ◽  
Krishna Hari Bhandari ◽  
Dong Xun Li ◽  
Jong Oh Kim ◽  
Dong Sung Yoo ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Solid Dispersions ◽  
Immediate Release ◽  
Polyethylene Glycol 4000 ◽  
Preparation And Evaluation

scholarly journals EFFECT OF SELECTED POLYMERS ON DISSOLUTION AND STABILIZATION OF AMORPHOUS FORM OF MELOXICAM

2017 ◽  
Vol 9 (9) ◽  
pp. 33
Author(s):  
Rana Obaidat ◽  
Bashar Al-taani ◽  
Hanan Al-quraan
Keyword(s):  
Polyethylene Glycol ◽  
Solid Dispersions ◽  
Dissolution Profile ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
Polyethylene Glycol 4000 ◽  
Amorphous Form ◽  
Molecular Weights ◽  
Low Solubility ◽  
Reproducible Manner

Objective: Meloxicam is classified as class II corresponding to its high permeability and low solubility (12μg/ml). This study aims to compare the effect of selected polymers on stabilization of amorphous form, and dissolution of meloxicam by preparation of different solid dispersions using selected polymers (chitosan oligomers, polyvinylpyrrolidone K30, and polyethylene glycols).Methods: These solid dispersions were prepared using two different methods; solvent evaporation method for the two molecular weights chitosan carriers (16 and 11KDa) and polyvinylpyrrolidone-K30 and melting method for the two different molecular weights polyethylene glycol (4000 and 6000). The physicochemical properties of solid dispersions were analyzed using differential scanning calorimetry, Fourier transform infra-red analysis, Powder X-ray diffraction, and scanning electron microscopy. Selected dispersions were then compared to two selected marketed drugs (Mobic® and Moven®).Results: Best dissolution rates were obtained for both polyvinylpyrrolidone-K30 and polyethylene glycol 6000, followed by chitosan 16 kDa, chitosan 11 kDa, and polyethylene glycol 4000. Increasing polymeric ratio increased dissolution rate except for chitosan. Precipitation of the drug as amorphous form occurred in chitosan and polyvinylpyrrolidone-K30 dispersions, while no change in crystallinity obtained for polyethylene glycol dispersions. Failure of polyvinylpyrrolidone-K30 in the maintenance of stability during storage time was observed while re-crystallization occurred in chitosan-based dispersions, which ends with preferences to polyethylene glycol dispersions. After comparing the release of selected dispersions with the two selected polymers; all dispersions got a higher release than that of the two marketed drugs release.Conclusion: The dissolution profile of meloxicam has been increased successfully in a reproducible manner.

Physicochemical characterization and in vivo properties of Zolpidem in solid dispersions with polyethylene glycol 4000 and 6000

1999 ◽  
Vol 184 (1) ◽  
pp. 121-130 ◽  
Author(s):  
Giuseppe Trapani ◽  
Massimo Franco ◽  
Andrea Latrofa ◽  
Maria Rosaria Pantaleo ◽  
Maria Rosaria Provenzano ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Solid Dispersions ◽  
Physicochemical Characterization ◽  
Polyethylene Glycol 4000

scholarly journals Preparation and Evaluation of Fast Dissolving Ibuprofen-Polyethylene Glycol 6000 Solid Dispersions

Drug Delivery ◽  
2008 ◽  
Vol 15 (6) ◽  
pp. 355-364 ◽  
Author(s):  
Madhuri Newa ◽  
Krishna H. Bhandari ◽  
Jung-Ae Kim ◽  
Bong-Kyu Yoo ◽  
Han-Gon Choi ◽  
...  
Keyword(s):  
Polyethylene Glycol ◽  
Solid Dispersions ◽  
Polyethylene Glycol 6000 ◽  
Preparation And Evaluation
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