scholarly journals On the Sulfation and Methylation of Catecholestrogens in Human Mammary Epithelial Cells and Breast Cancer Cells

2008 ◽  
Vol 31 (4) ◽  
pp. 769-773 ◽  
Author(s):  
Ying Hui ◽  
Shin Yasuda ◽  
Ming-Yih Liu ◽  
Yi-yong Wu ◽  
Ming-Cheh Liu
Keyword(s):  
Breast Cancer ◽  
Epithelial Cells ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial

scholarly journals YB-1 Transforms Human Mammary Epithelial Cells Through Chromatin Remodeling Leading to the Development of Basal-Like Breast Cancer

Stem Cells ◽  
2014 ◽  
Vol 32 (6) ◽  
pp. 1437-1450 ◽  
Author(s):  
Alastair H. Davies ◽  
Kristen M. Reipas ◽  
Mary Rose Pambid ◽  
Rachel Berns ◽  
Anna L. Stratford ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Epithelial Cells ◽  
Chromatin Remodeling ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial ◽  
Basal Like Breast Cancer

scholarly journals Benign mammary epithelial cells enhance the transformed phenotype of human breast cancer cells

BMC Cancer ◽  
2010 ◽  
Vol 10 (1) ◽  
Author(s):  
Joanna M Poczobutt ◽  
John Tentler ◽  
Xian Lu ◽  
Pepper J Schedin ◽  
Arthur Gutierrez-Hartmann
Keyword(s):  
Breast Cancer ◽  
Epithelial Cells ◽  
Cancer Cells ◽  
Human Breast Cancer ◽  
Breast Cancer Cells ◽  
Mammary Epithelial Cells ◽  
Mammary Epithelial ◽  
Human Breast Cancer Cells ◽  
Human Breast

scholarly journals c-Myc Transforms Human Mammary Epithelial Cells through Repression of the Wnt Inhibitors DKK1 and SFRP1

2007 ◽  
Vol 27 (14) ◽  
pp. 5135-5146 ◽  
Author(s):  
Victoria H. Cowling ◽  
Celina M. D'Cruz ◽  
Lewis A. Chodosh ◽  
Michael D. Cole
Keyword(s):  
Breast Cancer ◽  
Epithelial Cells ◽  
Target Genes ◽  
Mammary Epithelial Cells ◽  
Tumor Formation ◽  
Mammary Epithelial ◽  
Breast Cancer Cell Lines ◽  
Human Mammary Epithelial Cells ◽  
Human Mammary Epithelial ◽  
Wnt Inhibitors

ABSTRACT c-myc is frequently amplified in breast cancer; however, the mechanism of myc-induced mammary epithelial cell transformation has not been defined. We show that c-Myc induces a profound morphological transformation in human mammary epithelial cells and anchorage-independent growth. c-Myc suppresses the Wnt inhibitors DKK1 and SFRP1, and derepression of DKK1 or SFRP1 reduces Myc-dependent transforming activity. Myc-dependent repression of DKK1 and SFRP1 is accompanied by Wnt target gene activation and endogenous T-cell factor activity. Myc-induced mouse mammary tumors have repressed SFRP1 and increased expression of Wnt target genes. DKK1 and SFRP1 inhibit the transformed phenotype of breast cancer cell lines, and DKK1 inhibits tumor formation. We propose a positive feedback loop for activation of the c-myc and Wnt pathways in breast cancer.

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