scholarly journals Enhanced c-Fms/M-CSF Receptor Signaling and Wound-Healing Process in Bone Marrow-Derived Macrophages of Signal-Transducing Adaptor Protein-2 (STAP-2) Deficient Mice

2008 ◽  
Vol 31 (9) ◽  
pp. 1790-1793 ◽  
Author(s):  
Osamu Ikeda ◽  
Yuichi Sekine ◽  
Ryuta Muromoto ◽  
Norihiko Ohbayashi ◽  
Akihiko Yoshimura ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Healing Process ◽  
Adaptor Protein ◽  
Wound Healing Process ◽  
Receptor Signaling ◽  
Deficient Mice

Transplantation of Bone Marrow Cells Preactivated With Sodium Nitroprusside Improves Acute Wound Healing in Rabbits

2021 ◽  
pp. 153473462110290
Author(s):  
Nazira Fatima ◽  
Muhammad Saleem
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Sodium Nitroprusside ◽  
Bone Marrow Cells ◽  
Healing Process ◽  
Wound Healing Process ◽  
Inflammatory Infiltration ◽  
Acute Wound ◽  
High Concentrations ◽  
Marrow Cells

The development of wound healing impairment mainly represents challenging clinical problems. The less and high concentrations of nitric oxide can influence angiogenesis, remodeling, and proliferation of skin cells. Delayed acute wounds generally have failed to progress via the normal stages of healing. Such wounds usually enter a state of pathological inflammation due to a postponed, incomplete, and uncoordinated healing process. This study aimed to investigate the effect of normal bone marrow cells (BMCs) and preconditioning of BMCs with minimum concentrations of sodium nitroprusside (NaNP) solution for acute wound healing. For acute wound healing, full-thickness dorsal wounds were created on rabbits. The acute wound of rabbits was treated with BMCs and preactivated BMCs with NaNP. Histological results showed that BMCs preactivated with NaNP could improve collagen deposition, enhanced reepithelization, and decreased inflammatory infiltration. Overall, BMCs treated with NaNP can help to improve acute wound healing in rabbits. The result strongly confirmed the beneficial effect in augmenting the wound healing process. The combination of BMCs with NaNP was safe and convenient for acute wound healing.

scholarly journals Knockdown of Tcf3 enhances the wound healing effect of bone marrow mesenchymal stem cells in rats

2019 ◽  
Vol 39 (8) ◽  
Author(s):  
Bin He ◽  
Jia Chen ◽  
Liang Liu ◽  
Hao Wang ◽  
Shaohua Wang ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Healing Process ◽  
Wound Healing Process ◽  
Down Regulation ◽  
Healing Effect ◽  
Marrow Mesenchymal Stem Cells ◽  
Wound Healing Effect

AbstractThe aim of the present study was to explore the wound healing effect of Tcf3 in rat bone marrow mesenchymal stem cells (BMSCs) and their effects on wound healing. Epidermal growth factor (EGF) and fibroblast growth factors (FGFs) were used to induce BMSCs differentiation into epithelial-like cells. Western Blotting analysis and RT-qPCR were performed to assess the expression levels of Tcf3 and the markers of epithelial-like cells, such as Cytokeratin-18 (CK-18), CK-19 and P63. Cell counting kit-8 (CCK-8) and clone formation assay were carried out to detect cell viability. Immunohistochemistry and HE staining were used to assess the level of Tcf3 protein and skin repair degree, respectively. Rat wound healing model was built to evaluate the effects of BMSCs with altered expression of Tcf3 on wound healing. Results showed that EGF and FGFs stimulation increased the expression of CK-18, CK-19 and P63, improved BMSCs viability, but decreased the expression of Tcf3. Knockdown of Tcf3 in BMSCs increased CK-18, CK-19 and P63 expression and improved cell proliferation, as well as accelerated wound healing process. Moreover, inhibition of Wnt/β-catenin signaling weakened the effect of Tcf3 down-regulation on BMSCs proliferation enhancement. And inhibition of Notch1 signaling impeded the epithelial-like cell differentiation of BMSCs induced by Tcf3 down-regulation. Our study reveals that knockdown of Tcf3 enhances the wound healing process of BMSCs in rat, which provides new approach for accelerating skin regeneration.

scholarly journals Essential involvement of IL-6 in the skin wound-healing process as evidenced by delayed wound healing in IL-6-deficient mice

2003 ◽  
Vol 73 (6) ◽  
pp. 713-721 ◽  
Author(s):  
Zi-Qing Lin ◽  
Toshikazu Kondo ◽  
Yuko Ishida ◽  
Tatsunori Takayasu ◽  
Naofumi Mukaida
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Skin Wound ◽  
Wound Healing Process ◽  
Skin Wound Healing ◽  
Delayed Wound Healing ◽  
Deficient Mice

scholarly journals Mini Review : Liver Fibrosis Mechanism

2017 ◽  
Vol 3 (6) ◽  
pp. 327
Author(s):  
Wiwik Misaco Yuniarti ◽  
Hardany Primarizky
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Liver Fibrosis ◽  
Chronic Condition ◽  
Epithelial To Mesenchymal Transition ◽  
Healing Process ◽  
Wound Healing Process ◽  
Mesenchymal Transition ◽  
Liver Fibrogenesis ◽  
Severe Disorder

Liver fibrosis is the process of wound healing in the liver that caused by a various causes. The longer time of wound healing process, the more severe disorder will be. This chronic condition is characterized by excessive deposition of extracellular matrix then ended with fribrosis. This mini review describes about the phase of liver fibrogenesis. Even though there are many variations of fibrogenesis in animals and human, in general there are three fibrogenic cells that involved in fibrogenesis. These three cells are fibroblast or endogenous fibroblast like-cells, epithelial to mesenchymal transition (EMT), and fibrocytes that derived from bone-marrow. Keywords : liver, fibrosis, fibroblast, EMT, fibrocytes, collagen

Plasminogen is a critical regulator of cutaneous wound healing

2016 ◽  
Vol 115 (05) ◽  
pp. 1001-1009 ◽  
Author(s):  
Rima Sulniute ◽  
Yue Shen ◽  
Yong-Zhi Guo ◽  
Mahsa Fallah ◽  
Nina Ahlskog ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Healing Process ◽  
Inflammatory Cells ◽  
Wound Healing Process ◽  
Tissue Remodelling ◽  
Inflammatory Phase ◽  
Human Plasminogen ◽  
Supplementary Material ◽  
Deficient Mice

SummaryWound healing is a complicated biological process that consist of partially overlapping inflammatory, proliferation and tissue remodelling phases. A successful wound healing depends on a proper activation and subsequent termination of the inflammatory phase. The failure to terminate the inflammation halts the completion of wound healing and is a known reason for formation of chronic wounds. Previous studies have shown that wound closure is delayed in plasminogendeficient mice, and a role for plasminogen in dissection of extracellular matrix was suggested. However, our finding that plasminogen is transported to the wound by inflammatory cells early during the healing process, where it potentiates inflammation, indicates that plasminogen may also have other roles in the wound healing process. Here we report that plasminogen-deficient mice have extensive fibrin and neutrophil depositions in the wounded area long after re-epithelialisation, indicating inefficient debridement and chronic inflammation. Delayed formation of granulation tissue suggests that fibroblast function is impaired in the absence of plasminogen. Therefore, in addition to its role in the activation of inflammation, plasminogen is also crucial for subsequent steps, including resolution of inflammation and activation of the proliferation phase. Importantly, supplementation of plasminogen-deficient mice with human plasminogen leads to a restored healing process that is comparable to that in wild-type mice. Besides of being an activator of the inflammatory phase during wound healing, plasminogen is also required for the subsequent termination of inflammation. Based on these results, we propose that plasminogen may be an important future therapeutic agent for wound treatment.Supplementary Material to this article is available online at www.thrombosis-online.com.

scholarly journals Using autologous red bone marrow aspirates for acceleration of wound healing

2020 ◽  
pp. 135-140
Author(s):  
S. D. Fedzianin
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Chronic Wounds ◽  
Healing Process ◽  
Randomized Study ◽  
Main Group ◽  
Control Group ◽  
Wound Healing Process ◽  
Second Phase ◽  
Red Bone Marrow

Objectives: to develop a method for management of chronic wounds based on the use of autologous red bone marrow aspirates.Material and methods. A randomized study of the second phase of the wound healing process was conducted in 72 patients with chronic wounds. The standard methods were used to assess the dynamics of the wound healing process.Results. The rate of the wound healing process in the main group was Me 6.0 (LQ 5.0; UQ 35.0) % per day, and in the control group — 3.0 (LQ 3.0; UQ 28.0) % per day, which was authentically twice as high in the use of autologous red bone marrow aspirates (p = 0.00036). The duration of the phase of granulation tissue formation and maturation in the main group was Me 5.0 (LQ 3.0; UQ 7.0) days, and in the control group — Me 12.0 (LQ 9.0; UQ 15.0) (p < 0.00001).Conclusion. The developed method of wound healing acceleration is characterized by its technical simplicity, convenience and cheapness. Its use makes it possible with high fidelity to reduce the duration of the second phase of the wound healing process by 7 days and leads to a two-fold increase in the healing rate of wound defects.

HUBUNGAN MOBILISASI DINI TERHADAP PENYEMBUHAN LUKA POST OPERASI SECTIO CESARIA

2019 ◽  
Vol 2 (1) ◽  
pp. 14-17
Author(s):  
Nurul Aini Siagian ◽  
Syafira Nusaibah ◽  
Andayani Boang Manalu
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Early Mobilization ◽  
Sectio Caesarea ◽  
Wound Healing Process ◽  
P Value ◽  
Cross Sectional ◽  
Care Services ◽  
Healing Wound ◽  
Rapid Healing

Early mobilization includes factors that can affect the process of wound healing after surgery. Immediate mobilization in stages is very useful for the process of healing wounds and preventing infection and venous thrombosis. The purpose of this study was to determine whether there is a relationship between early mobilization and the process of healing wound post operative sectio caesarea at Sinar Husni General Hospital Medan Helvetia. The research design used was analytic survey with cross sectional approach. The sample in this study used the Consecutive Sampling method of data collection using a checklist sheet conducted on a sample of 19 respondents. The results of the study in this study are the majority of respondents who did early mobilization and who experienced rapid wound healing process as many as 4 people (21%) while the minority of respondents who did early mobilization and who experienced slow wound healing process were 1 person (5.3%). The majority of respondents who did not mobilize early and who experienced a slow wound healing process were 11 people (57.9%) and a minority who did not mobilize early and who experienced rapid healing as many as 4 people (21.1%). Statistical test results obtained p value = 0.046 <0.005. The conclusions of the results of this study indicate there is a relationship between early mobilization and the process of healing post operative sectio of caesarea. Suggestions The results of this study can be applied as a reference to improve nursing care services, especially in providing counseling and assistance to patients.

Hubungan Status Gizi Dengan Proses Penyembuhan Luka Di Rsud H. Andi Sulthan Daeng Radja Kabupaten Bulukumba

2017 ◽  
Vol 2 (1) ◽  
pp. 20-28
Author(s):  
Fitriani ◽  
Tenriwati
Keyword(s):  
Wound Healing ◽  
Nutritional Status ◽  
Healing Process ◽  
Data Retrieval ◽  
Observational Research ◽  
Wound Healing Process ◽  
P Value ◽  
Chi Square ◽  
Cross Sectional ◽  
Chi Square Test

At present, the incidence of injuries in Indonesia is quite high, as seen from data on traffic accidents in the general public. There are several factors that affect wound healing, one of which is nutritional status. Based on the preliminary data retrieval conducted by researchers in the seruni surgery room in the last 1 month namely in March, it was found that the number of wounded patients was 109 patients, where the number of men was 78 (71.56%) while the number of women was 31 ( 28.44%) The purpose of this study was to determine the relationship between nutritional status and the wound healing process in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. This research uses the type of design of this research is quantitative research. This type of research uses analytic observational research with cross sectional approach. The sample of this study were 41 respondents taken by purposive sampling method. Data analysis in this study used the chi-square test (chi square test). The results of the analysis used the chi-square statistical test with a confidence level (α = 0.05). Based on the results of this test, the p value is 0.001, thus p <α (0.001 <0.05), then Ho is rejected and Ha is accepted. The conclusion of this study is that there is a relationship between nutritional status and the process of wound healing in RSUD. H. Andi. Sulthan Daeng Radja Kab. Bulukumba. Researchers suggest that this study be used as a material consideration in the fulfillment of nutrition in wound care patients in RSUD.H.A. Sulthan Daeng Radja Kab. Bulukumba and this research can be continued by conducting research related to the wound healing process and linking it with other variables.

Natural, Synthetic and their Combinatorial Nanocarriers Based Drug Delivery System in the Treatment Paradigm for Wound Healing Via Dermal Targeting

2020 ◽  
Vol 26 (36) ◽  
pp. 4551-4568
Author(s):  
Mohammad Kashif Iqubal ◽  
Sadaf Saleem ◽  
Ashif Iqubal ◽  
Aiswarya Chaudhuri ◽  
Faheem Hyder Pottoo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Photodynamic Therapy ◽  
Growth Factors ◽  
Combination Therapy ◽  
Healing Process ◽  
Wound Healing Process ◽  
Wound Site ◽  
Synthetic Drugs ◽  
Treatment Paradigm

A wound refers to the epithelial loss, accompanied by loss of muscle fibers collagen, nerves and bone instigated by surgery, trauma, frictions or by heat. Process of wound healing is a compounded activity of recovering the functional integrity of the damaged tissues. This process is mediated by various cytokines and growth factors usually liberated at the wound site. A plethora of herbal and synthetic drugs, as well as photodynamic therapy, is available to facilitate the process of wound healing. Generally, the systems used for the management of wounds tend to act through covering the ruptured site, reduce pain, inflammation, and prevent the invasion and growth of microorganisms. The available systems are, though, enough to meet these requirements, but the involvement of nanotechnology can ameliorate the performance of these protective coverings. In recent years, nano-based formulations have gained immense popularity among researchers for the wound healing process due to the enhanced benefits they offer over the conventional preparations. Hereupon, this review aims to cover the entire roadmap of wound healing, beginning from the molecular factors involved in the process, the various synthetic and herbal agents, and combination therapy available for the treatment and the current nano-based systems available for delivery through the topical route for wound healing.

Scientific aspect on Diet explained by Susrutha in Wound Healing

2017 ◽  
Vol 2 (05) ◽  
Author(s):  
Manoj Kumar ◽  
Amareshappa . ◽  
Anjali Bharadwaj ◽  
Shailaja S. V.
Keyword(s):  
Wound Healing ◽  
Mineral Metabolism ◽  
Healing Process ◽  
Surgical Techniques ◽  
The Body ◽  
Wound Healing Process ◽  
Human Being ◽  
Different Sources ◽  
Scientific Aspect ◽  
Important Branch

Wound healing has been the burning problem in a surgical practice because of a remarkable increase in the number of traumatic cases. A wound causes a number of changes in the body that can affect the healing process, including changes in energy, protein, carbohydrate, fat, vitamin and mineral metabolism. Various Ayurveda literatures, particularly, Sushruta Samhita, which is said to be an ancient textbook of surgery in Ayurveda, has mentioned about the diet for the person suffering from the wound, and the author said that diet plays a very important role in the wound healing process. Sushruta - The father of surgery has scientifically classified it in a systemic manner, whose wealth of clinical material and the principles of management are valid even today. Shalya Tantra (surgical branch in Ayurveda Science) is one of the important branch of Ayurveda, in which surgical and para-surgical techniques has described for management of various diseases. Vrana is the most important and widely described chapter of Shalya Tantra. Vrana (wound) is one of them, which have been managed by human being from starting of civilization. Under the circumstances, the first thing which the men came across was the injury from different sources which caused him the Vrana. Vrana is seen as debilitating and scaring disorder, usually seen affecting the human being at any age. Well balanced nutrition plays an essential role in the wound healing.

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