scholarly journals Dexamethasone Inhibits Leukocyte Accumulation and Vascular Permeability in Retina of Streptozotocin-Induced Diabetic Rats via Reducing Vascular Endothelial Growth Factor and Intercellular Adhesion Molecule-1 Expression

2008 ◽  
Vol 31 (8) ◽  
pp. 1541-1546 ◽  
Author(s):  
Kang Wang ◽  
Yanling Wang ◽  
Lixin Gao ◽  
Xinmin Li ◽  
Mingming Li ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Vascular Permeability ◽  
Adhesion Molecule ◽  
Diabetic Rats ◽  
Intercellular Adhesion Molecule ◽  
Vascular Endothelial ◽  
Intercellular Adhesion Molecule 1 ◽  
Leukocyte Accumulation ◽  
Endothelial Growth Factor

Die Häufigkeit von Anti-VEGF-A-Injektionen und Ödemrezidiven hängt vom Grad der begleitenden lokalen zellulären Entzündung ab

2017 ◽  
Vol 3 (2) ◽  
pp. 70-71
Author(s):  
Olaf Strauss
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Adhesion Molecule ◽  
Growth Factor Receptor ◽  
Platelet Derived Growth Factor ◽  
Intercellular Adhesion Molecule ◽  
Vascular Endothelial ◽  
Intercellular Adhesion Molecule 1 ◽  
Endothelial Growth Factor ◽  
Zentrale Netzhautdicke

Wir maßen die Konzentrationen von Zytokinen und Wachstums-/Entzündungsfaktoren im Kammerwasser von 46 Patienten mit retinalem Venenastverschluss (VAV) und Makulaödem (MÖ), die mit einer intravitrealen Ranibizumab-Injektion (IRI) behandelt wurden. Patienten mit rezidivierendem MÖ erhielten bei Bedarf eine weitere IRI. Die Anzahl der IRI-Behandlungen korrelierte signifikant mit dem Alter, dem Visus c.c. bei Studienbeginn, der zentralen Netzhautdicke bei Studienbeginn sowie den Konzentrationen von 5 Zytokinen/Faktoren im Kammerwasser bei Studienbeginn (löslicher VEGFR-1 (vascular endothelial growth factor receptor 1), PDGF-AA (platelet-derived growth factor-AA), lösliches ICAM-1 (intercellular adhesion molecule 1), IL-6 (Interleukin 6) und IL-8). Die multivariate lineare Regressionsanalyse mit schrittweiser Auswahl bestätigte, dass Alter, zentrale Netzhautdicke bei Studienbeginn und PDGF-AA-Wert bei Studienbeginn unabhängige Determinanten der Anzahl der IRI-Behandlungen waren. Diese Ergebnisse deuten darauf hin, dass Entzündungsfaktoren möglicherweise das erneute Auftreten von MÖ bei VAV-Patienten beeinflussen können und dass der PDGF-AA-Wert ein hilfreicher Indikator dafür sein könnte, wie viele IRI-Behandlungen für die Beherrschung des MÖ erforderlich sein werden.

scholarly journals Small vessel disease and biomarkers of endothelial dysfunction after ischaemic stroke

2018 ◽  
Vol 4 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Francesco Arba ◽  
Alessio Giannini ◽  
Benedetta Piccardi ◽  
Silvia Biagini ◽  
Vanessa Palumbo ◽  
...  
Keyword(s):  
Vascular Endothelial Growth Factor ◽  
Growth Factor ◽  
Endothelial Dysfunction ◽  
Adhesion Molecule ◽  
Small Vessel Disease ◽  
Small Vessel ◽  
Intercellular Adhesion Molecule ◽  
Vascular Endothelial ◽  
Vessel Disease ◽  
Endothelial Growth Factor

Introduction Although pathogenesis of small vessel disease is poorly understood, increasing evidence suggests that endothelial dysfunction may have a relevant role in development and progression of small vessel disease. In this cross-sectional study, we investigated the associations between imaging signs of small vessel disease and blood biomarkers of endothelial dysfunction at two different time points in a population of ischaemic stroke patients. Patients and methods In stroke patients treated with intravenous thrombolysis, we analysed blood levels of von Willebrand factor, intercellular adhesion molecule-1, vascular cell adhesion molecule-1 and vascular endothelial growth factor. Three reviewers independently assessed small vessel disease features using computed tomography. At baseline and 90 days after the index stroke, we tested the associations between single and combined small vessel disease features and levels of blood biomarkers using linear regression analysis adjusting for age, sex, hypertension, diabetes, smoke. Results A total of 263 patients were available for the analysis. Mean age (±SD) was 69 (±13) years, 154 (59%) patients were male. We did not find any relation between small vessel disease and endothelial dysfunction at baseline. At 90 days, leukoaraiosis was independently associated with intercellular adhesion molecule-1 (β = 0.21; p = 0.016) and vascular cell adhesion molecule-1 (β = 0.22; p = 0.009), and lacunes were associated with vascular endothelial growth factor levels (β = 0.21; p = 0.009) whereas global small vessel disease burden was associated with vascular endothelial growth factor (β = 0.26; p = 0.006). Discussion Leukoaraiosis and lacunes were associated with endothelial dysfunction, which could play a key role in pathogenesis of small vessel disease. Conclusions Small vessel disease features and total burden were associated with endothelial dysfunction 90 days after the stroke, whereas there was no relation during the acute phase. Our results suggest that endothelial dysfunction, particularly vascular endothelial growth factor, is involved in pathological process of small vessel disease.

Sign in / Sign up

Export Citation Format

Share Document