scholarly journals Inhibitory Effect of Schizandrin on Passive Cutaneous Anaphylaxis Reaction and Scratching Behaviors in Mice

2007 ◽  
Vol 30 (6) ◽  
pp. 1153-1156 ◽  
Author(s):  
Bomi Lee ◽  
Eun-Ah Bae ◽  
Hien Trung Trinh ◽  
Yong-Wook Shin ◽  
Thien Thuong Phuong ◽  
...  
Keyword(s):  
Inhibitory Effect ◽  
Passive Cutaneous Anaphylaxis ◽  
Passive Cutaneous Anaphylaxis Reaction

The Pharmacology of Passive Cutaneous Anaphylaxis in the Calf

1972 ◽  
Vol 50 (3) ◽  
pp. 255-262 ◽  
Author(s):  
P. W. Wells ◽  
P. Eyre
Keyword(s):  
Latent Period ◽  
Horse Serum ◽  
Inhibitory Effect ◽  
Threshold Dose ◽  
Antigen Challenge ◽  
Passive Cutaneous Anaphylaxis ◽  
Disodium Cromoglycate ◽  
Diethylcarbamazine Citrate ◽  
Anaphylactic Response ◽  
Passive Cutaneous Anaphylaxis Reaction

The effects of mepyramine maleate, sodium meclofenamate, methysergide bimaleate, diethylcarbamazine citrate, and disodium cromoglycate on bovine cutaneous anaphylactic reactions and responses to intradermal injections of histamine, 5-hydroxytryptamine, and bradykinin were studied. Calves sensitized by immunization with horse serum in Freund's complete adjuvant were bled to obtain skin-sensitizing serum which was used in passive cutaneous anaphylaxis (P.C.A.) tests. A latent period of 72 h was allowed between intradermal injections of sera and antigen challenge. Mepyramine maleate (10 mg/kg) selectively inhibited responses to histamine and raised the threshold dose of antibody required to elicit a response. Disodium cromoglycate (DSCG, 10 mg/kg) given intravenously 30 min or immediately prior to challenge had no significant effect either on the responses to drugs or on the passive cutaneous anaphylaxis reaction. Diethylcarbamazine (DECC, 20 mg/kg) administered immediately prior to challenge significantly inhibited the cutaneous anaphylactic response and when DSCG was given simultaneously with DECC, this inhibitory effect was apparently augmented. Methysergide (1 mg/kg) and sodium meclofenamate (2 mg/kg) were ineffective in suppressing P.C.A. It is concluded that histamine and a slow-reacting substance (SRS-A) are involved in the mediation of bovine cutaneous anaphylaxis and that kinins may contribute, while 5-hydroxytryptamine would appear unimportant.

Mangiferin Inhibits Passive Cutaneous Anaphylaxis Reaction and Pruritus in Mice

Planta Medica ◽  
2009 ◽  
Vol 75 (13) ◽  
pp. 1415-1417 ◽  
Author(s):  
Bomi Lee ◽  
Hien Trung Trinh ◽  
Eun-Ah Bae ◽  
Kangshik Jung ◽  
Dong-Hyun Kim
Keyword(s):  
Passive Cutaneous Anaphylaxis ◽  
Passive Cutaneous Anaphylaxis Reaction
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