scholarly journals Retraction：Effects of Pre- and Post-ischemic Treatments with FK409, a Nitric Oxide Donor, on Ischemia/Reperfusion-Induced Renal Injury and Endothelin-1 Production in Rats

2006 ◽  
Vol 29 (3) ◽  
pp. 577-579 ◽  
Author(s):  
Atsushi Nakajima ◽  
Kyoko Ueda ◽  
Masanori Takaoka ◽  
Hayato Kurata ◽  
Junji Takayama ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Renal Injury ◽  
Ischemia Reperfusion ◽  
Nitric Oxide Donor ◽  
Endothelin 1

Nitric oxide attenuates endothelin-1-induced vasoconstriction in canine stomach

1996 ◽  
Vol 271 (1) ◽  
pp. G27-G35
Author(s):  
J. G. Wood ◽  
Q. Zhang ◽  
Z. Y. Yan ◽  
L. Y. Cheung
Keyword(s):  
Nitric Oxide ◽  
Methyl Ester ◽  
Ischemia Reperfusion ◽  
Nitric Oxide Donor ◽  
Question Mark ◽  
Endothelin 1 ◽  
Vasoconstrictor Response ◽  
Anesthetized Dogs ◽  
Spermine Nonoate

We previously observed that endothelin-1 (ET-1)-induced gastric vasoconstriction is enhanced after ischemia-reperfusion. The purpose of our present study was to examine the role of nitric oxide in regulating ET-1-induced vasoconstriction under normal conditions and after ischemia-reperfusion. Using a mechanically perfused stomach segment from chloralose-anesthetized dogs, we examined 1) responses to NG-nitro-L-arginine methyl ester (L-NAME) alone and in combination with L-arginine, 2) whether L-NAME affects ET-1-induced vasoconstriction under normal conditions and after ischemia-reperfusion, and 3) if spermine NONOate inverted question mark1,3-propanediamine-N-[4-1-(3-aminopropyl)-2-hydroxy-2-nitrosohydrazi no] butyl; a nitric oxide donor inverted question mark attenuates the augmented response to ET-1 after ischemia-reperfusion. Our results show that 1) L-NAME significantly increased baseline vascular resistance and this response was reduced by L-arginine, 2) ET-1-induced vasoconstriction was enhanced by L-NAME, and 3) administration of spermine NONOate during reperfusion largely attenuated the vasoconstrictor response to ET-1 after ischemia-reperfusion. Our findings are consistent with the hypothesis that nitric oxide modulates responses to ET-1 under normal conditions, and loss of this vasodilator after ischemia-reperfusion results in an augmented response to ET-1.

Protective effect of nitric oxide on ischemia/reperfusion-induced renal injury and endothelin-1 overproduction

2005 ◽  
Vol 517 (3) ◽  
pp. 232-239 ◽  
Author(s):  
Hayato Kurata ◽  
Masanori Takaoka ◽  
Yasuhiro Kubo ◽  
Tomoaki Katayama ◽  
Hidenobu Tsutsui ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Protective Effect ◽  
Renal Injury ◽  
Ischemia Reperfusion ◽  
Endothelin 1

RETRACTION: Opposite Effects of Pre- and Postischemic Treatments with Nitric Oxide Donor on Ischemia/Reperfusion-Induced Renal Injury

2005 ◽  
Vol 316 (3) ◽  
pp. 1038-1046 ◽  
Author(s):  
Atsushi Nakajima ◽  
Kyoko Ueda ◽  
Masanori Takaoka ◽  
Yoshiko Yoshimi ◽  
Yasuo Matsumura
Keyword(s):  
Nitric Oxide ◽  
Renal Injury ◽  
Ischemia Reperfusion ◽  
Nitric Oxide Donor

Effects of Nitric Oxide Donor Antioxidants Containing the Phenol Vitamin E Substructure and a Furoxan Moiety on Ischemia/Reperfusion Injury

2011 ◽  
Vol 59 (03) ◽  
pp. 111-116
Author(s):  
Antonella Di Stilo ◽  
Konstantin Chegaev ◽  
Loretta Lazzarato ◽  
Roberta Fruttero ◽  
Alberto Gasco ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Vitamin E ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Nitric Oxide Donor

The nitric oxide donor molsidomine prevents ischemia/reperfusion injury of the adult rat small intestine

2003 ◽  
Vol 19 (4) ◽  
pp. 305-308 ◽  
Author(s):  
Hayrettin Öztürk ◽  
Mustafa Aldemir ◽  
Ali İhsan Dokucu ◽  
Yusuf Yağmur ◽  
Nihal Kilinç ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Small Intestine ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Nitric Oxide Donor ◽  
Rat Small Intestine ◽  
Adult Rat

scholarly journals FK409, a novel nitric oxide donor, inhibits endothelin-1 production in cultured endothelial cells

1997 ◽  
Vol 73 ◽  
pp. 164
Author(s):  
Naoko Mrtsuiomi ◽  
Yasuo Matsummura ◽  
Chitose Atashi ◽  
Masanori Takaoka ◽  
Shiro Morimoto
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cells ◽  
Nitric Oxide Donor ◽  
Endothelin 1 ◽  
Cultured Endothelial Cells

scholarly journals Influence of Hypoxic and Hyperoxic Preconditioning on Endothelial Function in a Model of Myocardial Ischemia-Reperfusion Injury with Cardiopulmonary Bypass (Experimental Study)

2020 ◽  
Vol 21 (15) ◽  
pp. 5336
Author(s):  
Irina A. Mandel ◽  
Yuri K. Podoksenov ◽  
Irina V. Suhodolo ◽  
Darya A. An ◽  
Sergey L. Mikheev ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cardiopulmonary Bypass ◽  
Endothelial Function ◽  
Light Microscopy ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Control Group ◽  
Endothelin 1 ◽  
Nitric Oxide Metabolites

The aim of the experiment was to evaluate the effect of preconditioning based on changes in inspiratory oxygen fraction on endothelial function in the model of ischemia-reperfusion injury of the myocardium in the condition of cardiopulmonary bypass. The prospective randomized study included 32 rabbits divided into four groups: hypoxic preconditioning, hyperoxic preconditioning, hypoxic-hyperoxic preconditioning, and control group. All animals were anesthetized and mechanically ventilated. We provided preconditioning, then started cardiopulmonary bypass, followed by induced acute myocardial infarction (ischemia 45 min, reperfusion 120 min). We investigated endothelin-1, nitric oxide metabolites, asymmetric dimethylarginine during cardiopulmonary bypass: before ischemia, after ischemia, and after reperfusion. We performed light microscopy of myocardium, kidney, lungs, and gut mucosa. The endothelin-1 level was much higher in the control group than in all preconditioning groups after ischemia. The endothelin-1 even further increased after reperfusion. The total concentration of nitric oxide metabolites was significantly higher after all types of preconditioning compared with the control group. The light microscopy of the myocardium and other organs revealed a diminished damage extent in the hypoxic-hyperoxic preconditioning group as compared to the control group. Hypoxic-hyperoxic preconditioning helps to maintain the balance of nitric oxide metabolites, reduces endothelin-1 hyperproduction, and enforces organ protection.

Obestatin improves ischemia/reperfusion-induced renal injury in rats via its antioxidant and anti-apoptotic effects: Role of the nitric oxide

Peptides ◽  
2014 ◽  
Vol 60 ◽  
pp. 23-31 ◽  
Author(s):  
Mehmet Koç ◽  
Zarife Nigâr Özdemir Kumral ◽  
Naziye Özkan ◽  
Gülsün Memi ◽  
Ömer Kaçar ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Renal Injury ◽  
Ischemia Reperfusion ◽  
Apoptotic Effects
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