scholarly journals Simultaneous Determination of Protocatechuic Acid, Syringin, Chlorogenic Acid, Caffeic Acid, Liriodendrin and Isofraxidin in Acanthopanax senticosus HARMS by HPLC-DAD

2006 ◽  
Vol 29 (3) ◽  
pp. 532-534 ◽  
Author(s):  
Qing Li ◽  
Ying Jia ◽  
Liang Xu ◽  
Xiaohui Wang ◽  
Zhenduo Shen ◽  
...  
Keyword(s):  
Chlorogenic Acid ◽  
Simultaneous Determination ◽  
Caffeic Acid ◽  
Protocatechuic Acid ◽  
Acanthopanax Senticosus

Simultaneous determination of gallic acid，chlorogenic acid and caffeic acid contents in Ganmao’an granules by HPLC method

2012 ◽  
Vol 12 (6) ◽  
pp. 427-430
Author(s):  
FangJian CHEN ◽  
HongJie SONG ◽  
HongBn GAO ◽  
ZhiJun WANG ◽  
Peng FU ◽  
...  
Keyword(s):  
Chlorogenic Acid ◽  
Gallic Acid ◽  
Simultaneous Determination ◽  
Caffeic Acid ◽  
Hplc Method

scholarly journals Simultaneous Determination of Chlorogenic Acid Isomers and Metabolites in Rat Plasma Using LC-MS/MS and Its Application to A Pharmacokinetic Study Following Oral Administration of Stauntonia Hexaphylla Leaf Extract (YRA-1909) to Rats

Pharmaceutics ◽  
2018 ◽  
Vol 10 (3) ◽  
pp. 143 ◽  
Author(s):  
Won-Gu Choi ◽  
Ju-Hyun Kim ◽  
Dong Kim ◽  
Yongnam Lee ◽  
Ji Yoo ◽  
...  
Keyword(s):  
Oral Administration ◽  
Chlorogenic Acid ◽  
Simultaneous Determination ◽  
Caffeic Acid ◽  
Pharmacokinetic Study ◽  
Leaf Extract ◽  
Rat Plasma ◽  
Mass Spectrometric Method ◽  
Tandem Mass Spectrometric

Stauntonia hexaphylla leaf extract (YRA-1909), which is widely used for the antirheumatic properties, has been under phase 2 clinical trials in patients with rheumatoid arthritis since April 2017. Liquid chromatography-tandem mass spectrometric method while using liquid–liquid extraction with ethyl acetate was validated for the simultaneous determination of the major active components of YRA-1909, including chlorogenic acid (CGA), neochlorogenic acid (NCGA), cryptochlorogenic acid (CCGA), and their metabolites (i.e., caffeic acid (CA), caffeic acid 3-O-glucuronide (CA-3-G), caffeic acid 4-O-glucuronide (CA-4-G), and ferulic acid (FA)) in rat plasma and applied to a pharmacokinetic study of YRA-1909 in rats. Seven analytes were separated on Halo C18 while using gradient elution of formic acid and methanol, and then quantified in selected reaction monitoring mode whle using negative electrospray ionization. Following oral administration of YRA-1909 at doses of 25, 50, and 100 mg/kg to male Sprague-Dawley rats, CGA, NCGA, and CCGA were rapidly absorbed and metabolized to CA, CA-3-G, and CA-4-G. The area under the plasma concentration-time curve (AUClast) of CGA, NCGA, CCGA, and three metabolites linearly increased as the YRA-1909 dose increased. Other pharmacokinetic parameters were comparable among three doses studied. AUClast values for CA, CA-3-G, and CA-4-G exceeded those for CGA, NCGA, and CCGA.

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