Inhibitory Effects of Naringenin on Tumor Growth in Human Cancer Cell Lines and Sarcoma S-180-Implanted Mice

2005 ◽  
Vol 28 (3) ◽  
pp. 527-530 ◽  
Author(s):  
Syu-ichi Kanno ◽  
Ayako Tomizawa ◽  
Takako Hiura ◽  
Yuu Osanai ◽  
Ai Shouji ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Inhibitory Effects ◽  
Human Cancer Cell Lines

scholarly journals A New Cytotoxic Cyclolanostane Triterpenoid Xyloside from Souliea vaginata

2017 ◽  
Vol 12 (2) ◽  
pp. 1934578X1701200 ◽  
Author(s):  
Haifeng Wu ◽  
Zhixin Yang ◽  
Qiru Wang ◽  
Nailiang Zhu ◽  
Xudong Xu ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Hepg2 Cells ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Hepatoprotective Effect ◽  
Human Cancer Cell ◽  
Inhibitory Effects ◽  
Chemical Methods ◽  
Human Cancer Cell Lines

A new cyclolanostane triterpenoid xyloside, soulieoside P (1), and a known oleanane-type saponin, hederasaponin B (2), were isolated from the rhizomes of Souliea vaginata. Their structures were established by extensive spectroscopic and HRESIMS analysis, as well as chemical methods. Compound 1 showed significant inhibitory effects with IC50 values of 7.6–11.2 μM against three human cancer cell lines, while compound 2 exhibited no hepatoprotective effect on CCl4-induced injury of human HepG2 cells, in the tested range of 0.1–100 μM.

scholarly journals Suppression of the Oncogenic Transcription Factor FOXM1 by Proteasome Inhibitors

Scientifica ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Andrei L. Gartel
Keyword(s):  
Transcription Factor ◽  
Tumor Growth ◽  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Proteasome Inhibitors ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines ◽  
Oncogenic Transcription Factor

The oncogenic transcription factor FOXM1 is one of the key regulators of tumorigenesis. We found that FOXM1 upregulates its own transcription and its protein stability depends on its interaction with the chaperone nucleophosmin. We also determined that FOXM1 is negatively regulated by the tumor suppressor p53. We identified the thiazole antibiotics Siomycin A and thiostrepton as inhibitors of transcriptional activity and FOXM1 expression via proteasome inhibition. In addition, we found that all tested proteasome inhibitors target FOXM1. We showed synergy between thiostrepton and bortezomib in different human cancer cell lines andin vivo.We generated isogenic human cancer cell lines of different origin with wild-type p53 or p53 knockdown and we demonstrated that proteasome inhibitors induce p53-independent apoptosis in these cells. Using RNA-interference or proteasome inhibitors to inhibit FOXM1 we found that suppression of FOXM1 sensitized human cancer cells to apoptosis induced by DNA-damaging agents or oxidative stress. We encapsulated thiostrepton into micelle-nanoparticles and after injection we detected accumulation of nanoparticles in tumors and in the livers of treated mice. This treatment led to inhibition of human xenograft tumor growth in nude mice. Our data indicate that targeting FOXM1 increases apoptosis and inhibits tumor growth.

Further Halotyrosine Derivatives from the Marine Sponge Suberea aff. praetensa

2002 ◽  
Vol 57 (7-8) ◽  
pp. 732-738 ◽  
Author(s):  
Anake Kijjoa ◽  
Rawiwan Watanadilok ◽  
Pichai Sonchaeng ◽  
Pichan Sawangwong ◽  
Madalena Pedro ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Marine Sponge ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Gulf Of Thailand ◽  
Human Cancer Cell ◽  
Inhibitory Effects ◽  
Human Cancer Cell Lines ◽  
The Gulf Of Thailand

Reexamination of the marine sponge Suberea aff. praetensa, (Row) from the Gulf of Thailand furnished in addition to bromotyrosine derivatives found previously 5-bromo- and 5- chlorocavernicolin, cavernicolins 1 and 2, two other brominated tyrosine metabolites, a known bisoxazolidone and a new unusual rearranged tyrosine metabolite subereatensin. Several of the metabolites exhibited significant inhibitory effects against five human cancer cell lines.

scholarly journals Identification of ubiquitin in bovine milk and its growth inhibitory effects on human cancer cell lines

2010 ◽  
Vol 93 (8) ◽  
pp. 3442-3452 ◽  
Author(s):  
C. Freiburghaus ◽  
C. Welinder ◽  
U. Tjörnstad ◽  
H. Lindmark-Månsson ◽  
M. Paulsson ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Human Cancer ◽  
Bovine Milk ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Inhibitory Effects ◽  
Human Cancer Cell Lines ◽  
Growth Inhibitory

Constituents of Polyalthia jucunda and their cytotoxic effect on human cancer cell lines

Planta Medica ◽  
2007 ◽  
Vol 73 (09) ◽  
Author(s):  
IO Mondranondra ◽  
A Suedee ◽  
A Kijjoa ◽  
M Pinto ◽  
N Nazareth ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Human Cancer ◽  
Cancer Cell Lines ◽  
Human Cancer Cell ◽  
Human Cancer Cell Lines
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