scholarly journals Contribution of Human Hepatic Cytochrome P450 Isoforms to the Metabolism of Psychotropic Drugs

2005 ◽  
Vol 28 (9) ◽  
pp. 1711-1716 ◽  
Author(s):  
Toshiro Niwa ◽  
Toshifumi Shiraga ◽  
Ikuko Ishii ◽  
Akira Kagayama ◽  
Akira Takagi
Keyword(s):  
Cytochrome P450 ◽  
Psychotropic Drugs ◽  
Cytochrome P450 Isoforms ◽  
Hepatic Cytochrome

Inductive effect of tobacco smoke on mouse pulmonary and hepatic cytochrome P450 isoforms

1994 ◽  
Vol 74 ◽  
pp. 91 ◽  
Author(s):  
P.H. Villard ◽  
E. Seree ◽  
B. Lacarelle ◽  
M.C. Therene-Fenoglio ◽  
L. Attolini ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Tobacco Smoke ◽  
Inductive Effect ◽  
Cytochrome P450 Isoforms ◽  
Hepatic Cytochrome

Metabolism of 7-benzyloxy-4-trifluoromethylcoumarin by human hepatic cytochrome P450 isoforms

Xenobiotica ◽  
2000 ◽  
Vol 30 (10) ◽  
pp. 955-969 ◽  
Author(s):  
A. B. Renwick ◽  
D. Surry ◽  
R. J. Price ◽  
B. G. Lake ◽  
D. C. Evans
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Isoforms ◽  
Hepatic Cytochrome

Biotransformation of Benfluron by Rat Hepatic Cytochrome P450. Identification of Individual CYP-Enzymes Involved in Biotransformation of Benfluron, Prospective Antineoplastic Based on Benzo[c]fluorene

2000 ◽  
Vol 65 (8) ◽  
pp. 1374-1386 ◽  
Author(s):  
Kamil Hrubý ◽  
Eva Anzenbacherová ◽  
Pavel Anzenbacher ◽  
Milan Nobilis
Keyword(s):  
Cytochrome P450 ◽  
Drug Interactions ◽  
Enzyme Activities ◽  
Cytochromes P450 ◽  
Antineoplastic Agent ◽  
Marker Enzyme ◽  
Cyp Enzymes ◽  
Cytochrome P450 Isoforms ◽  
Low Activity ◽  
Hepatic Cytochrome

Benfluron, 5-[2-(dimethylamino)ethoxy]-7H-benzo[c]fluoren-7-one hydrochloride, a prospective antineoplastic agent, is metabolised by cytochromes P450 to N-demethyl and 9-hydroxy derivatives. To prove the participation of individual cytochrome P450 isoforms in formation of these metabolites, selective induction of cytochromes P450, inhibition of benfluron biotransformation using inhibitors specific for individual cytochromes P450, and inhibition by benfluron of "marker" enzyme activities characteristic of certain cytochromes P450 were used. N-Demethylbenfluron appears to be formed mainly by the cytochromes P450 of the 3A, 2B and 2C subfamilies with possible participation of the isoform 2E1; 9-hydroxybenfluron is formed with participation of cytochromes P450 belonging to 1A, and most probably to 3A and 2E1 enzymes. The fact that benfluron is in this respect a relatively promiscuous substrate may be an advantage because its metabolism should not be influenced by the absence or low activity of some cytochrome P450 isoforms and by possible drug interactions.

Sex dictates the constitutive expression of hepatic cytochrome P450 isoforms in Göttingen minipigs

2019 ◽  
Vol 314 ◽  
pp. 181-186 ◽  
Author(s):  
Martin Krøyer Rasmussen ◽  
Carsten Scavenius ◽  
Sabine Gerbal-Chaloin ◽  
Jan Enghild
Keyword(s):  
Cytochrome P450 ◽  
Constitutive Expression ◽  
Cytochrome P450 Isoforms ◽  
Hepatic Cytochrome

Vinclozolin modulates hepatic cytochrome P450 isoforms during pregnancy

2015 ◽  
Vol 53 ◽  
pp. 119-126 ◽  
Author(s):  
Félix Genoveva García-Montes de Oca ◽  
Ma. de Lourdes López-González ◽  
Derly Constanza Escobar-Wilches ◽  
Roberto Chavira-Ramírez ◽  
Adolfo Sierra-Santoyo
Keyword(s):  
Cytochrome P450 ◽  
Cytochrome P450 Isoforms ◽  
Hepatic Cytochrome

Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones

Xenobiotica ◽  
1998 ◽  
Vol 28 (6) ◽  
pp. 539-547 ◽  
Author(s):  
T. NIWA ◽  
Y. YABUSAKI ◽  
K. HONMA ◽  
N. MATSUO ◽  
K. TATSUTA ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Steroid Hormones ◽  
Cytochrome P450 Isoforms ◽  
Regioselective Hydroxylation ◽  
Hepatic Cytochrome

scholarly journals INDUCTION OF HEPATIC CYTOCHROME P450 ISOFORMS BY NICARDIPINE AT THERAPEUTIC DOSES IN SPONTANEOUSLY HYPERTENSIVE RATS

2007 ◽  
Vol 32 (1) ◽  
pp. 79-90 ◽  
Author(s):  
Shoji MIYAJIMA ◽  
Kiyomitsu NEMOTO ◽  
Masashi SEKIMOTO ◽  
Yusuke KINAE ◽  
Toshihiko KASAHARA ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Cytochrome P450 Isoforms ◽  
Therapeutic Doses ◽  
Hepatic Cytochrome
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