scholarly journals Comparison of the Inhibitory Effects of Docosahexaenoic Acid (DHA) on U46619- and Phenylephrine-Induced Contractions in Guinea-Pig Aorta

2005 ◽  
Vol 28 (7) ◽  
pp. 1298-1300 ◽  
Author(s):  
Kazuoki Otsuka ◽  
Yoshio Tanaka ◽  
Hikaru Tanaka ◽  
Katsuo Koike ◽  
Koki Shigenobu
Keyword(s):  
Docosahexaenoic Acid ◽  
Guinea Pig ◽  
Inhibitory Effects

Inhibitory effects of quercetin on guinea-pig ileum contractions

1996 ◽  
Vol 10 (1) ◽  
pp. 66-69 ◽  
Author(s):  
J. Gálvez ◽  
J. Duarte ◽  
F. Sánchez de Medina ◽  
J. Jiménez ◽  
A. Zarzuelo
Keyword(s):  
Guinea Pig ◽  
Inhibitory Effects ◽  
Guinea Pig Ileum

Inhibitory effects of flavonoids on phosphodiesterase isozymes from guinea pig and their structure–activity relationships

2004 ◽  
Vol 68 (10) ◽  
pp. 2087-2094 ◽  
Author(s):  
Wun-Chang Ko ◽  
Chwen-Ming Shih ◽  
Ya-Hsin Lai ◽  
Jun-Hao Chen ◽  
Hui-Lin Huang
Keyword(s):  
Guinea Pig ◽  
Inhibitory Effects ◽  
Structure Activity Relationships ◽  
Structure Activity

scholarly journals Inhibitory effects of azimilide on K+ currents in isolated guinea-pig cardiomyocytes

2000 ◽  
Vol 82 ◽  
pp. 96
Author(s):  
Atsushi Nishida ◽  
Hiroko Uemura ◽  
Takehiko Ogura ◽  
Yoshie Furusawa ◽  
Hideo Yabana ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Inhibitory Effects ◽  
K Currents

Excitatory and inhibitory effects of toluene on neural activity in guinea pig hippocampal slices

1993 ◽  
Vol 158 (1) ◽  
pp. 63-66 ◽  
Author(s):  
Youji Ikeuchi ◽  
Hirokazu Hirai ◽  
Yasuhiro Okada ◽  
Takaya Mio ◽  
Toshiji Matsuda
Keyword(s):  
Guinea Pig ◽  
Neural Activity ◽  
Hippocampal Slices ◽  
Inhibitory Effects

Anti -Platelet Effects Of Ticlopidine Are Not Diminished By Efa Deficiency Cr Inecmet1Hacin Aemini Stoat Icn

1981 ◽  
Author(s):  
A L Willis ◽  
J M Fisher ◽  
D Donegan ◽  
D L Smith
Keyword(s):  
Fatty Acid ◽  
Guinea Pig ◽  
Platelet Function ◽  
Abdominal Aorta ◽  
Intraperitoneal Administration ◽  
Sprague Dawley ◽  
Inhibitory Effects ◽  
Final Dose ◽  
Endogenous Production ◽  
Induced Aggregation

It has been suggested that ticlopidine may act to sensitize platelets to the effects of anti-aggregatory prostaglandins ( I2, E1, D2) or enhance endogenous production of such PG’s. Rats (male, Sprague Dawley, 280-575g, Simonsen, Gilroy, CA) or guinea pigs, (male, Hartley strain, 330-410g, Simonsen) were dosed o rally with ticlopidine hydrochloride (RS 99847) at 100 mg/kg for 3 days. At 2h following the final dose, platelet function (ADP-induced aggregation, retention by glass beads) was examined within 5 min of blood withdrawal via the abdominal aorta. In rats chronically maintained on a fat-free diet, there is a deficiency in tissue levels of essential fatty acid (EFA) precursors for PG biosynthesis. Consequently, a marked (∼90%) reduction in platelet PG production and vascular PGI2 production was seen. Under such conditions, administration of ticlopidine hydrochloride inhibited platelet function in a manner indistinguishable from that in control animals. Similarly, in both guinea pig and rat, intraperitoneal administration of indcmethacin (100 mg/kg) lh before the final dose of ticlopidine failed to interfere with the anti-plate let effects of ticlopidine, even though vascular PGI2 production (in thoracic aorta) was shown to be virtually abolished. It is concluded that EFA’s and their PG metabolites are not necessary for the platelet inhibitory effects of ticlopidine to be exerted.

scholarly journals Inhibitory effects of isoprenaline and calcium on contractions of guinea pig ileal longitudinal muscle

1977 ◽  
Vol 27 ◽  
pp. 162
Author(s):  
Yukio Ishida ◽  
Nobuaki Kondo ◽  
Kaoruko Fujii ◽  
Yoshiko Sekimoto
Keyword(s):  
Guinea Pig ◽  
Longitudinal Muscle ◽  
Inhibitory Effects

scholarly journals Abolishment of inhibitory effects of 3'-deazaadenosine on Superoxide generation of guinea pig phagocytes by pre-exposure to phorbol myristate acetate

FEBS Letters ◽  
1986 ◽  
Vol 201 (2) ◽  
pp. 287-290 ◽  
Author(s):  
Katsuro Yagawa ◽  
Masayuki Nakanishi ◽  
Shinichiro Hayashi ◽  
Mariko Kaku ◽  
Yukito Ichinose ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Phorbol Myristate Acetate ◽  
Inhibitory Effects ◽  
Myristate Acetate ◽  
Superoxide Generation

scholarly journals Inhibitory effects of paraquat on guinea pig ileum contraction

1997 ◽  
Vol 73 ◽  
pp. 105
Author(s):  
Joji Tomioka ◽  
Shinichiro Suzaki ◽  
Akira Kurokawa ◽  
Yasuhiro Yamamoto ◽  
Toshibumi Oluka ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Inhibitory Effects ◽  
Guinea Pig Ileum ◽  
Ileum Contraction
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