scholarly journals Inhibition of Theophylline Metabolism by Suplatast and Its Metabolites in Rats

2005 ◽  
Vol 28 (6) ◽  
pp. 1061-1065 ◽  
Author(s):  
Makiko Kizawa ◽  
Etsuko Miyamoto ◽  
Shuka Aono ◽  
Junichi Kawakami ◽  
Isao Adachi
Keyword(s):  
Theophylline Metabolism

scholarly journals Effects of enoxacin and ciprofloxacin on the theophylline metabolism in humans.

1991 ◽  
Vol 38 (4) ◽  
pp. 372-378
Author(s):  
Soo Jeon Choi ◽  
Bong Choon Lee ◽  
Dong Soon Kim
Keyword(s):  
Theophylline Metabolism

scholarly journals Effect of Q-35, New Pyridone Carboxylic Acid, on Theophylline Metabolism in Rat Liver Microsomes.

1993 ◽  
Vol 8 (2) ◽  
pp. 239-245
Author(s):  
Yoshiaki NABUCHI ◽  
Keiichi YANO ◽  
Yoshinori ASOH ◽  
Kouichi TANAKA ◽  
Michiaki TAKATOH
Keyword(s):  
Carboxylic Acid ◽  
Rat Liver ◽  
Liver Microsomes ◽  
Rat Liver Microsomes ◽  
Theophylline Metabolism

Limitation of theophylline elimination by reduced oxygen availability in mouse hepatocytes and rat isolated livers

1985 ◽  
Vol 63 (8) ◽  
pp. 903-907 ◽  
Author(s):  
Kanji Nakatsu
Keyword(s):  
Oxygen Supply ◽  
Correlation Coefficients ◽  
Oxygen Availability ◽  
Isolated Perfused Rat Liver ◽  
Mouse Hepatocyte ◽  
Mouse Hepatocytes ◽  
Per Se ◽  
Theophylline Metabolism ◽  
Effect Of Oxygen ◽  
Rat Livers

The effect of oxygen availability on theophylline metabolism by mouse hepatocytes and rat isolated livers was examined. The elimination of theophylline by mouse hepatocytes and the metabolism of theophylline to dimethyluric acid by isolated, perfused rat livers was seriously impaired when the gas mixture supplied contained less than 28% oxygen. The correlation coefficients relating oxygen supply and the concentration of theophylline remaining in mouse hepatocyte suspensions were −0.74 to −0.84. In the isolated, perfused rat liver experiments, the correlation coefficient relating oxygen availability and dimethyluric acid production was 0.87. These observations are interpreted as supporting the hypothesis that oxygen availability per se is an important factor in determining the rate of theophylline metabolism.

Theophylline Metabolism after Cardiac Surgery

2001 ◽  
Vol 41 (2) ◽  
pp. 157-162 ◽  
Author(s):  
Kazunobu Hirooka ◽  
Masato Shimizu ◽  
Satoru Mineshita
Keyword(s):  
Cardiac Surgery ◽  
Theophylline Metabolism

Massive Theophylline Dosing in a Heavy Smoker Receiving Both Phenytoin and Phenobarbital

1992 ◽  
Vol 26 (3) ◽  
pp. 334-336
Author(s):  
James P. Nicholson ◽  
Sharon A. Basile ◽  
James D. Cury
Keyword(s):  
Single Case ◽  
Symptomatic Relief ◽  
University Teaching ◽  
Smoking History ◽  
Heavy Smoker ◽  
Serum Theophylline ◽  
Heavy Smoking ◽  
Single Case Report ◽  
Theophylline Metabolism ◽  
Additive Influence

OBJECTIVE: To report unusually high theophylline dosing requirements in a smoker receiving concomitant therapy with phenytoin and phenobarbital. DESIGN: Single case report. SETTING: 517-bed, university teaching hospital. PATIENT: 29-year-old woman with newly diagnosed asthma, heavy smoking history, and a seizure disorder. RESULTS: The additive influence of smoking, phenytoin, and phenobarbital greatly increased the theophylline dosing requirements. Doses of up to 4 g/d (59 mg/kg/d) were required to achieve adequate symptomatic relief of her asthma as well as to provide therapeutic serum theophylline concentrations. CONCLUSIONS: Multiple polymorphisms may additively influence theophylline metabolism and exceptionally large theophylline doses may be required in some patients who smoke and are comedicated with phenytoin and phenobarbital.

scholarly journals CAFFEINE AND THEOPHYLLINE METABOLISM IN OLDER PRETERM INFANTS

1987 ◽  
Vol 21 (4) ◽  
pp. 234A-234A
Author(s):  
Carlos Duran ◽  
Cheston M Berlin ◽  
Stephen A Pearlman ◽  
Mary A Wood
Keyword(s):  
Preterm Infants ◽  
Theophylline Metabolism

Caffeine and theophylline metabolism in newborn and adult human hepatocytes; comparison with adult rat hepatocytes

1988 ◽  
Vol 37 (19) ◽  
pp. 3691-3700 ◽  
Author(s):  
François Berthou ◽  
Damrong Ratanasavanh ◽  
Dominique Alix ◽  
Dominique Carlhant ◽  
Christian Riche ◽  
...  
Keyword(s):  
Rat Hepatocytes ◽  
Human Hepatocytes ◽  
Adult Rat ◽  
Adult Human ◽  
Adult Rat Hepatocytes ◽  
Theophylline Metabolism
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