scholarly journals Inhibitory Effects of α-Arbutin on Melanin Synthesis in Cultured Human Melanoma Cells and a Three-Dimensional Human Skin Model

2004 ◽  
Vol 27 (4) ◽  
pp. 510-514 ◽  
Author(s):  
Kazuhisa Sugimoto ◽  
Takahisa Nishimura ◽  
Koji Nomura ◽  
Kenji Sugimoto ◽  
Takashi Kuriki
Keyword(s):  
Human Skin ◽  
Three Dimensional ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Melanin Synthesis ◽  
Inhibitory Effects ◽  
Skin Model ◽  
Human Melanoma Cells

scholarly journals Inhibition of Melanin Synthesis by Cystamine in Human Melanoma Cells

2000 ◽  
Vol 114 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Ling Qiu ◽  
Mei Zhang ◽  
Ian Tonks ◽  
Graham Kay ◽  
Peter G. Parsons ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Melanin Synthesis ◽  
Human Melanoma Cells

scholarly journals Inhibitory Effects of Euphorbia tirucalli Lineu (Euphorbiaceae) Diluted Latex on Human and Canine Melanoma Cells

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Diego Pinha Alves da Paz ◽  
Márcia Kazumi Nagamine ◽  
Murilo Penteado Del Grande ◽  
João Vitor Pereira Leite ◽  
Flavia Mendonça Gonçalves Sobreira ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Control Group ◽  
Inhibitory Effects ◽  
Euphorbia Tirucalli ◽  
Human Melanoma Cells ◽  
Standard Solution ◽  
Canine Melanoma ◽  
Shape Curve ◽  
Toxic Plant

Euphorbia tirucalli Lineu (Euphorbiaceae) is a tropical and subtropical ornamental and toxic plant. E. tirucalli produces a latex that is commonly used to treat neoplasms. This study aimed to evaluate the effects of diluted E. tirucalli latex (DETL) on human (SK-MEL-28) and canine (CBMY) melanoma cells. SK-MEL-28 (3 × 103 cells/well) and CBMY (6 × 103 cells/well) were cultivated in 96-well plates. The cells were treated with 50 μl/well of dilutions (1/2, 1/4, 1/8, 1/16, 1/32, 1/64, 1/128, 1/256, and 1/512) of a standard solution containing 1 mg/mL of the E. tirucalli latex (ETL) in DMEM. Control group cells received 50 μl/well of DMEM. After 24, 48, and 72 h of treatment, cell viability was assessed by the MTT assay. There was a significant decrease in viability at 48 and 72 hours after treatment for human melanoma cells and at 24, 48, and 72 hours for canine cells, mainly in higher dilutions of ETL. Human melanoma cells presented a typical U shape curve, characteristic of hormesis. To our knowledge, this is the first study showing inhibitory effects of DETL on canine melanoma cells. Therefore, DETL is a potentially new antineoplastic drug.

Effects of alternol on proliferation and melanin synthesis of human melanoma cells

2018 ◽  
Vol 18 (2) ◽  
pp. 110-113
Author(s):  
YuNing REN ◽  
◽  
JiChun HAN ◽  
QiuSheng ZHENG
Keyword(s):  
Melanoma Cells ◽  
Human Melanoma ◽  
Melanin Synthesis ◽  
Human Melanoma Cells

Alterations of melanin synthesis in human melanoma cells selected in vitro for multidrug resistance

1995 ◽  
Vol 47 (2-3) ◽  
pp. 157-166 ◽  
Author(s):  
T.P. Stromskaya ◽  
N.A. Filippova ◽  
E.Yu. Rybalkina ◽  
S.V. Egudina ◽  
A.A. Shtil ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Melanin Synthesis ◽  
Human Melanoma Cells
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