scholarly journals Enhancement of Heme-Induced Membrane Damage by the Anti-malarial Clotrimazole: the Role of Colloid-Osmotic Forces

2004 ◽  
Vol 27 (3) ◽  
pp. 361-365 ◽  
Author(s):  
Nguyen Tien Huy ◽  
Ryo Takano ◽  
Saburo Hara ◽  
Kaeko Kamei
Keyword(s):  
Membrane Damage ◽  
Induced Membrane

The active role of Ca2+ ions in Aβ-mediated membrane damage

2018 ◽  
Vol 54 (29) ◽  
pp. 3629-3631 ◽  
Author(s):  
Michele F. M. Sciacca ◽  
Irene Monaco ◽  
Carmelo La Rosa ◽  
Danilo Milardi
Keyword(s):  
Calcium Ions ◽  
Membrane Damage ◽  
Active Role ◽  
Membrane Disruption ◽  
Induced Membrane ◽  
Membrane Poration

Calcium ions inhibits Aβ induced membrane poration by small-sized oligomers but significantly foster fiber-dependent membrane disruption.

scholarly journals AMELIORATIVE ROLE OF GARLIC (ALLIUM SATIVUM) ON CHROMIUM (VI) - INDUCED MEMBRANE DAMAGE IN MALE ALBINO RATS

2021 ◽  
pp. 69-72
Author(s):  
SOUMITA DEY ◽  
SANKAR KUMAR DEY
Keyword(s):  
Body Weight ◽  
Plasma Membrane ◽  
Aqueous Extract ◽  
Membrane Damage ◽  
The Body ◽  
Albino Rats ◽  
Treatment Schedule ◽  
Induced Membrane ◽  
Liver And Kidney

Objective: Membrane damage is one of the important consequences of chromium (Cr) induced cytotoxicity. Garlic possesses antioxidant property to scavenge the toxic radicals and cytoprotective activity. The aim of the present study is to evaluate the ameliorative role of aqueous extract of garlic (AEG) on Cr-induced membrane damage of both liver and kidneys in male albino rats. Methods: Male albino rats of Wistar strain (80-100 g) were used for the present study. Rats were divided into three groups of almost equal average body weight. The animals of two groups were injected K2Cr2O7 at a dose of 0.8 mg per 100 g body weight per day for 28 days. The animals of one of the Cr-treated groups served as the supplemented group supplied aqueous extract of garlic (AEG) (250 mg per kg body weight daily at an interval of 6 h after injection of Cr for a period of 28 days). The animals of the remaining group received only the vehicle (0.9% NaCl), served as control. The body weights of the animals were taken in each day of treatment schedule. Results: The results indicated that significant increases in membrane cholesterol level as well as significant decreases in membrane phospholipid level in Cr exposed animals suggest structural alterations in both liver and kidneys plasma membrane. Alkaline phosphatase (ALP), total ATPase, and Na+-K+- ATPase activities of plasma membrane were significantly decreased in both liver and kidneys after Cr treatment. On the other hand, AEG supplementation plays a vital role to restore such alterations induced by Cr in plasma membrane of both liver and kidney. Conclusion: These findings indicate that Cr treatment at the present dose and duration induces structural and functional alterations in the plasma membrane in both liver and kidney. However, AEG supplementation restored those alterations induced by Cr in plasma membrane of both liver and kidneys but was not able to eliminate the deposited Cr from the liver and kidney tissues.

scholarly journals Regulation of divalent metal ions to the aggregation and membrane damage of human islet amyloid polypeptide oligomers

RSC Advances ◽  
2021 ◽  
Vol 11 (21) ◽  
pp. 12815-12825
Author(s):  
Yajie Wang ◽  
Feihong Meng ◽  
Tong Lu ◽  
Chunyun Wang ◽  
Fei Li
Keyword(s):  
Metal Ions ◽  
Metal Binding ◽  
Membrane Damage ◽  
Islet Amyloid Polypeptide ◽  
Divalent Metal ◽  
Human Islet ◽  
Divalent Metal Ions ◽  
Islet Amyloid ◽  
Induced Membrane ◽  
Human Islet Amyloid Polypeptide

Their is a counteraction between a decrease in the disruptive ability of metal-associated oligomer species and an increase in the quantity of oligomers promoted by the metal binding in the activity of hIAPP induced membrane damage.

scholarly journals A Twins Heritability Study on Alpha Hemoglobin Stabilizing Protein (AHSP) Expression Variability

2010 ◽  
Vol 13 (6) ◽  
pp. 567-572 ◽  
Author(s):  
Mei I. Lai ◽  
Chad Garner ◽  
Jie Jiang ◽  
Nicholas Silver ◽  
Steve Best ◽  
...  
Keyword(s):  
Protein Expression ◽  
Membrane Damage ◽  
Therapeutic Interventions ◽  
Ineffective Erythropoiesis ◽  
Red Cell Membrane ◽  
Cell Membrane Damage ◽  
Expression Variability ◽  
Hemoglobin Tetramer ◽  
Genetic Heritability

Cytotoxic precipitation of free α-globin monomers and its production of reactive oxygen species cause red cell membrane damage that leads to anemia and eventually ineffective erythropoiesis in β-thalassemia. Alpha hemoglobin stabilizing protein (AHSP) was found to bind only to free α-globin monomers creating a stable and inert complex which remains soluble in the cytoplasm thus preventing harmful precipitations. Alpha hemoglobin stabilizing protein was shown to bind nascent α-globin monomers with transient strength before transferring α-globin to β-globin to form hemoglobin tetramer. A classical twin study would be beneficial to investigate the role of genetics and environment in the variation of alpha hemoglobin stabilizing protein expression as this knowledge will enable us to determine further investigations with regards to therapeutic interventions if alpha hemoglobin stabilizing protein is to be a therapeutic agent for β-thalassemia. This study investigates the heritability influence of alpha hemoglobin stabilizing protein expression and factors that may contribute to this. Results indicated that a major proportion of alpha hemoglobin stabilizing protein expression was influenced by genetic heritability (46%) withcis-acting factors accounting for 19% andtrans-acting factors at 27%.

Generation of Free Radicals and Enhancement of Hemin-induced Membrane Damage by a Catechol Iron Chelator in Plasmodium falciparum

2005 ◽  
Vol 5 (4) ◽  
pp. 463-471 ◽  
Author(s):  
B. Pradines . ◽  
F. Ramiandrasoa . ◽  
T. Fusai . ◽  
A. Hammadi . ◽  
M. Henry . ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Free Radicals ◽  
Membrane Damage ◽  
Iron Chelator ◽  
Induced Membrane

scholarly journals Intracellular pHluorin as Sensor for Easy Assessment of Bacteriocin-Induced Membrane-Damage in Listeria monocytogenes

2018 ◽  
Vol 9 ◽  
Author(s):  
Peter Crauwels ◽  
Leonie Schäfer ◽  
Dominik Weixler ◽  
Nadav S. Bar ◽  
Dzung B. Diep ◽  
...  
Keyword(s):  
Listeria Monocytogenes ◽  
Membrane Damage ◽  
Induced Membrane

Photodynamic Activity of Substituted Zinc Trisulfophthalocyanines: Role of Plasma Membrane Damage

2006 ◽  
Vol 82 (6) ◽  
pp. 1712-1720 ◽  
Author(s):  
Nicole Cauchon ◽  
Moni Nader ◽  
Ghassan Bkaily ◽  
Johan E. Lier ◽  
Darel Hunting
Keyword(s):  
Plasma Membrane ◽  
Membrane Damage ◽  
Plasma Membrane Damage ◽  
Photodynamic Activity
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