scholarly journals Mycelial Extract of Cordyceps ophioglossoides Prevents Neuronal Cell Death and Ameliorates β-Amyloid Peptide-Induced Memory Deficits in Rats

2004 ◽  
Vol 27 (7) ◽  
pp. 1126-1129 ◽  
Author(s):  
Da-Qing Jin ◽  
Byung-Chul Park ◽  
Jae-Seong Lee ◽  
Hee-Don Choi ◽  
Yong-Soo Lee ◽  
...  
Keyword(s):  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Memory Deficits ◽  
Amyloid Peptide ◽  
Mycelial Extract ◽  
Β Amyloid ◽  
Β Amyloid Peptide

Strength training or green tea prevent memory deficits in a β-amyloid peptide-mediated Alzheimer's disease model

2021 ◽  
Vol 143 ◽  
pp. 111186
Author(s):  
Helen L. Schimidt ◽  
Guilherme S. Carrazoni ◽  
Alexandre Garcia ◽  
Ivan Izquierdo ◽  
Pâmela B. Mello-Carpes ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Strength Training ◽  
Green Tea ◽  
Disease Model ◽  
Memory Deficits ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

A novel compound, RS-1178, specifically inhibits neuronal cell death mediated by β-amyloid-induced macrophage activation in vitro

2002 ◽  
Vol 946 (2) ◽  
pp. 298-306 ◽  
Author(s):  
Shigeko Uryu ◽  
Shinya Tokuhiro ◽  
Takako Murasugi ◽  
Tomiichiro Oda
Keyword(s):  
Cell Death ◽  
Macrophage Activation ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Β Amyloid

Neuregulins Rescue PC12-ErbB-4 Cells From Cell Death Induced by β-Amyloid Peptide: Involvement of PI3K and PKC

2005 ◽  
Vol 26 (1) ◽  
pp. 057-070 ◽  
Author(s):  
Ayelet Di Segni ◽  
Ezra Shaharabani ◽  
Reuven Stein ◽  
Ronit Pinkas-Kramarski
Keyword(s):  
Cell Death ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals Retraction: Protective Effect of HSP90 on Neuronal Cell Death-induced by beta-Amyloid Peptide

2020 ◽  
Vol 33 (3) ◽  
pp. 155
Author(s):  
Hyun Jung Lee ◽  
Do Hee Kim ◽  
Ok Hyun Kim ◽  
Yoon Hee Chung ◽  
Kyung Yong Kim ◽  
...  
Keyword(s):  
Cell Death ◽  
Protective Effect ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Beta Amyloid ◽  
Amyloid Peptide ◽  
Beta Amyloid Peptide

scholarly journals Ape1/Ref-1 Induces Glial Cell-Derived Neurotropic Factor (GDNF) Responsiveness by Upregulating GDNF Receptor α1 Expression

2009 ◽  
Vol 29 (8) ◽  
pp. 2264-2277 ◽  
Author(s):  
Mi-Hwa Kim ◽  
Hong-Beum Kim ◽  
Samudra Acharya ◽  
Hong-Moon Sohn ◽  
Jae Yeoul Jun ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cancer Cells ◽  
Glial Cell ◽  
Cancer Progression ◽  
Neuronal Cell ◽  
Amyloid Peptide ◽  
Pancreatic Cancer Cells ◽  
Β Amyloid ◽  
Neurotropic Factor ◽  
Β Amyloid Peptide

ABSTRACT Apurinic/apyrimidinic endonuclease 1 (Ape1/Ref-1) dysregulation has been identified in several human tumors and in patients with a variety of neurodegenerative diseases. However, the function of Ape1/Ref-1 is unclear. We show here that Ape1/Ref-1 increases the expression of glial cell-derived neurotropic factor (GDNF) receptor α1 (GFRα1), a key receptor for GDNF. Expression of Ape1/Ref-1 led to an increase in the GDNF responsiveness in human fibroblast. Ape1/Ref-1 induced GFRα1 transcription through enhanced binding of NF-κB complexes to the GFRα1 promoter. GFRα1 levels correlate proportionally with Ape1/Ref-1 in cancer cells. The knockdown of endogenous Ape1/Ref-1 in pancreatic cancer cells markedly suppressed GFRα1 expression and invasion in response to GNDF, while overexpression of GFRα1 restored invasion. In neuronal cells, the Ape1/Ref-1-mediated increase in GDNF responsiveness not only stimulated neurite outgrowth but also protected the cells from β-amyloid peptide and oxidative stress. Our results show that Ape1/Ref-1 is a novel physiological regulator of GDNF responsiveness, and they also suggest that Ape1/Ref-1-induced GFRα1 expression may play important roles in pancreatic cancer progression and neuronal cell survival.

scholarly journals Caspase-2 Mediates Neuronal Cell Death Induced by β-Amyloid

2000 ◽  
Vol 20 (4) ◽  
pp. 1386-1392 ◽  
Author(s):  
Carol M. Troy ◽  
Sylvia A. Rabacchi ◽  
Wilma J. Friedman ◽  
Thierry F. Frappier ◽  
Kristy Brown ◽  
...  
Keyword(s):  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Β Amyloid ◽  
Caspase 2

Thrombin Attenuates Neuronal Cell Death and Modulates Astrocyte Reactivity Induced by β-Amyloid In Vitro

2002 ◽  
Vol 66 (4) ◽  
pp. 1374-1382 ◽  
Author(s):  
Christian J. Pike ◽  
Patrick J. Vaughan ◽  
Dennis D. Cunningham ◽  
Carl W. Cotman
Keyword(s):  
Cell Death ◽  
Neuronal Cell Death ◽  
Neuronal Cell ◽  
Β Amyloid
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