scholarly journals Protective Effects of Polygodial on Gastric Mucosal Lesions Induced by Necrotizing Agents in Rats and the Possible Mechanisms of Action

2003 ◽  
Vol 26 (5) ◽  
pp. 651-657 ◽  
Author(s):  
Yutana Pongpiriyadacha ◽  
Hisashi Matsuda ◽  
Toshio Morikawa ◽  
Yasunobu Asao ◽  
Masayuki Yoshikawa
Keyword(s):  
Mechanisms Of Action ◽  
Protective Effects ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

scholarly journals Protective Effect of Pyrus ussuriensis Maxim. Extract against Ethanol-Induced Gastritis in Rats

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 439
Author(s):  
Naila Boby ◽  
Muhammad Aleem Abbas ◽  
Eon-Bee Lee ◽  
Zi-Eum Im ◽  
Walter H. Hsu ◽  
...  
Keyword(s):  
Therapeutic Option ◽  
Adenosine Monophosphate ◽  
Ethanol Ingestion ◽  
Dependent Manner ◽  
Protective Effects ◽  
Gastric Mucosal Lesions ◽  
Cellular Degeneration ◽  
Mucosal Lesions ◽  
Pyrus Ussuriensis Maxim

Pyrus ussuriensis Maxim (Korean pear) has been used for hundreds of years as a traditional herbal medicine for asthma, cough, and atopic dermatitis in Korea and China. Although it was originally shown to possess anti-inflammatory, antioxidant, and antiatopic properties, its gastroprotective effects have not been investigated. In the present study, we evaluated the protective effects of Pyrus ussuriensis Maxim extract (PUE) against ethanol-induced gastritis in rats. The bioactive compound profile of PUE was determined by gas chromatography mass spectroscopy (GC-MS) and high-performance liquid chromatography (HPLC). The gastroprotection of PUE at different doses (250 and 500 mg/kg body weight) prior to ethanol ingestion was evaluated using an in vivo gastritis rat model. Several endpoints were evaluated, including gastric mucosal lesions, cellular degeneration, intracellular damage, and immunohistochemical localization of leucocyte common antigen. The gastric mucosal injury and ulcer score were determined by evaluating the inflamed gastric mucosa and by histological examination. To identify the mechanisms of gastroprotection by PUE, antisecretory action and plasma prostaglandin E2 (PGE2), gastric mucosal cyclic adenosine monophosphate (cAMP), and histamine levels were measured. PUE exhibited significant antioxidant effects with IC50 values of 56.18 and 22.49 µg/mL for 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′- azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid (ABTS) inhibition (%), respectively. In addition, GC/MS and HPLC analyses revealed several bioactive compounds of PUE. Pretreatment with PUE significantly (P < 0.05) decreased the ulcer index by preventing gastric mucosal lesions, erosion, and cellular degeneration. An immunohistochemical analysis revealed that PUE markedly attenuated leucocyte infiltration in a dose-dependent manner. The enhancement of PGE2 levels and attenuation of cAMP levels along with the inhibition of histamine release following PUE pretreatment was associated with the cytoprotective and healing effects of PUE. In contrast, the downregulation of the H+/K+ ATPase pathway as well as muscarinic receptor (M3R) and histamine receptor (H2R) inhibition was also involved in the gastroprotective effects of PUE; however, the expression of cholecystokinin-2 receptors (CCK2R) was unchanged. Finally, no signs of toxicity were observed following PUE treatment. Based on our results, we conclude that PUE represents an effective therapeutic option to reduce the risk of gastritis and warrants further study.

Study of the Protective Effects of Flaxseed Oil on Ethanol Induced Gastric Mucosal Lesions in Non Ovariectomized and Ovariectomized Rats

2016 ◽  
Vol 12 (4) ◽  
pp. 329-339 ◽  
Author(s):  
Bassant M.M. Ibrahim ◽  
Abeer A.A. Salama ◽  
Heba M.I. Abdallah ◽  
Sally A. El Awdan ◽  
Nermeen M. Shaffie
Keyword(s):  
Flaxseed Oil ◽  
Ovariectomized Rats ◽  
Protective Effects ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

Protective effects of oleanolic acid oligoglycosides on ethanol- or indomethacin-induced gastric mucosal lesions in rats

Life Sciences ◽  
1998 ◽  
Vol 63 (17) ◽  
pp. PL245-PL250 ◽  
Author(s):  
Hisashi Matsuda ◽  
Yuhao Li ◽  
Toshiyuki Murakami ◽  
Johji Yamahara ◽  
Masayuki Yoshikawa
Keyword(s):  
Oleanolic Acid ◽  
Protective Effects ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

Isolation of a Wild Morchella spp. Strain and the Effects of its Extract on Ethanol-Induced Gastric Mucosal Lesions in Rats

2011 ◽  
Vol 66 (1-2) ◽  
pp. 55-62
Author(s):  
Wei Wei ◽  
Xia Luo ◽  
Linyong Zheng ◽  
Mengyao Yu ◽  
Nan Jiang ◽  
...  
Keyword(s):  
Superoxide Dismutase ◽  
Sequence Analysis ◽  
Phylogenetic Tree ◽  
Internal Transcribed Spacer ◽  
Protective Effects ◽  
Gastric Lesions ◽  
Sod Activity ◽  
Gastric Mucosal Lesions ◽  
Mucosal Lesions

A Morchella spp. strain was isolated from a wild morel mushroom, and the effects of its mycelia extract on the ethanol-induced gastric mucosal lesions of rats were investigated in vivo. Sequence analysis of internal transcribed spacer suggested that this Morchella spp. strain (strain No. M1) was clustered together with M. conica in the phylogenetic tree. The superoxide dismutase (SOD) activity increased significantly compared to the control. However, the malondialdehyde (MDA) level and myeloperoxidase (MPO) activity decreased significantly compared to the control. These results indicated that M1 is one member of M. conica and the protective effects of M1 extract against the ethanol-induced gastric lesions may be related to the increased SOD activity and decreased MDA level and MPO activity in rats.

Anti-oxidative Herbs and Indomethacin-Induced Rat Gastric Mucosal Lesions: Protection by GamiHyangsa-Yukgunja

2001 ◽  
Vol 29 (01) ◽  
pp. 101-109 ◽  
Author(s):  
Heung Mook Shin
Keyword(s):  
Antioxidant Defense ◽  
Gastric Lesion ◽  
Protective Effects ◽  
Gastric Mucosal Lesions ◽  
Morphological Alterations ◽  
Defense Systems ◽  
Tissue Damages ◽  
Antioxidant Defense Systems ◽  
Mucosal Lesions ◽  
Mucosa Cell

This study investigates the protective effects of GamiHyangsa-Yukgunja (GHY, a popular herbal medicine formula) on indomethacin-induced gastric mucosal lesions and morphological change in rats. Subcutaneous injection of indomethacin (25 mg/kg) produced the following gastric morphological alterations; mucosa hermorrhagic infarct, mucosa cell necrosis, leukocyte infiltration, mucosa hemorrhagic erosion, and gastric pit disappearance. Tissue damages were accompanied by increased oxidative stress, lipid peroxidation, and decreases in superoxide dismutase (SOD), and catalase (CAT) activities, and glutathione (GSH) concentrations. Our results show that pretreatment of the rats with orally administered GHY extract (3.3 ml/kg/day) significantly reduced gastric lesion formation and caused the amelioration of several pathological changes in the above-mentioned gastric mucosal lesions. Concomuitantly, GHY-pretreatment increased gastric mucosal SOD and CAT activities and GSH concentrations. We therefore propose that GHY exerts a prophylactic effect on the indomethacin-induced gastric mucosal lesions by enhancing antioxidant defense systems.

scholarly journals Protective Effects of Wheat Peptides against Ethanol-Induced Gastric Mucosal Lesions in Rats: Vasodilation and Anti-Inflammation

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2355
Author(s):  
Lanlan Yu ◽  
Ruijun Li ◽  
Wei Liu ◽  
Yalin Zhou ◽  
Yong Li ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Mucosal Blood Flow ◽  
Gastric Mucosal Blood Flow ◽  
Mucosal Injury ◽  
Ethanol Administration ◽  
Protective Effects ◽  
Sprague Dawley ◽  
Gastric Mucosal Lesions ◽  
Signaling Transduction Pathway ◽  
Mucosal Lesions

Alcohol consumption increases the risk of gastritis and gastric ulcer. Nutritional alternatives are considered for relieving the progression of gastric mucosal lesions instead of conventional drugs that produce side effects. This study was designed to evaluate the gastroprotective effects and investigate the defensive mechanisms of wheat peptides against ethanol-induced acute gastric mucosal injury in rats. Sixty male Sprague–Dawley rats were divided into six groups and orally treated with wheat peptides (0.1, 0.2, 0.4 g/kgbw) and omeprazole (20 mg/kgbw) for 4 weeks, following absolute ethanol administration for 1 h. Pretreatment with wheat peptides obviously enhanced the vasodilation of gastric mucosal blood vessels via improving the gastric mucosal blood flow and elevating the defensive factors nitric oxide (NO) and prostaglandin E2 (PGE2), and lowering the level of vasoconstrictor factor endothelin (ET)-1. Wheat peptides exhibited anti-inflammatory reaction through decreasing inducible nitric oxide synthase (iNOS) and pro-inflammatory cytokines tumor necrosis factor α (TNF-α), interleukin (IL)-1β, IL-6, and increasing trefoil factor 1 (TFF1) levels. Moreover, wheat peptides significantly down-regulated the expression of phosphorylated nuclear factor kappa-B (p-NF-κB) p65 proteins in the NF-κB signaling pathway. Altogether, wheat peptides protect gastric mucosa from ethanol-induced lesions in rats via improving the gastric microcirculation and inhibiting inflammation mediated by the NF-κB signaling transduction pathway.

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