Studies on Cancer Chemoprevention by Traditional Folk Medicines XXIV.—Inhibitory Effect of a Coumarin Derivative, 7-Isopentenyloxycoumarin, against Tumor-Promotion

2002 ◽  
Vol 25 (2) ◽  
pp. 244-246 ◽  
Author(s):  
Masaki Baba ◽  
Yongri Jin ◽  
Atsuo Mizuno ◽  
Hisaya Suzuki ◽  
Yoshihito Okada ◽  
...  
Keyword(s):  
Cancer Chemoprevention ◽  
Tumor Promotion ◽  
Coumarin Derivative ◽  
Inhibitory Effect

Inhibitory effect of Hibiscus protocatechuic acid on tumor promotion in mouse skin

1998 ◽  
Vol 126 (2) ◽  
pp. 199-207 ◽  
Author(s):  
Tsui-Hwa Tseng ◽  
Jeng-Dong Hsu ◽  
Ming-Hsiang Lo ◽  
Chia-Yih Chu ◽  
Fen-Pi Chou ◽  
...  
Keyword(s):  
Protocatechuic Acid ◽  
Mouse Skin ◽  
Tumor Promotion ◽  
Inhibitory Effect

Inhibitory Effect of Oral Administration of Monascus Pigment on Tumor Promotion in Two-Stage Carcinogenesis in Mouse Skin

Oncology ◽  
1996 ◽  
Vol 53 (3) ◽  
pp. 247-249 ◽  
Author(s):  
Ken Yasukawa ◽  
Masanao Takahashi ◽  
Sakae Yamanouchi ◽  
Michio Takido
Keyword(s):  
Oral Administration ◽  
Mouse Skin ◽  
Tumor Promotion ◽  
Inhibitory Effect ◽  
Two Stage ◽  
Monascus Pigment

Inhibitory effect of topical application of polymerized ferulic acid, a synthetic lignin, on tumor promotion in mouse skin two-stage tumorigenesis

1994 ◽  
Vol 15 (9) ◽  
pp. 2069-2071 ◽  
Author(s):  
Masaharu Asanoma ◽  
Kazuhiko Takahashi ◽  
Masaki Miyabe ◽  
Katsuhiko Yamamoto ◽  
Naoki Yoshimi ◽  
...  
Keyword(s):  
Ferulic Acid ◽  
Topical Application ◽  
Mouse Skin ◽  
Tumor Promotion ◽  
Inhibitory Effect ◽  
Two Stage

Inhibitory Effect of Taraxastane-Type Triterpenes on Tumor Promotion by 12-O-Tetradecanoylphorbol-13-Acetate in Two-Stage Carcinogenesis in Mouse Skin

Oncology ◽  
1996 ◽  
Vol 53 (4) ◽  
pp. 341-344 ◽  
Author(s):  
Ken Yasukawa ◽  
Toshihiro Akihisa ◽  
Hirotoshi Oinuma ◽  
Tomohiro Kaminaga ◽  
Hiroshi Kanno ◽  
...  
Keyword(s):  
Mouse Skin ◽  
Tumor Promotion ◽  
Inhibitory Effect ◽  
Two Stage

Inhibitory Effect of Toluene on Tumor Promotion in Mouse Skin

1986 ◽  
Vol 181 (2) ◽  
pp. 199-204 ◽  
Author(s):  
H. S. Weiss ◽  
J. F. O'Connell ◽  
A. G. Hakaim ◽  
W. T. Jacoby
Keyword(s):  
Mouse Skin ◽  
Tumor Promotion ◽  
Inhibitory Effect

Effects of Simultaneous Dietary Exposure to 2,2′,4,4′,5,5′-Hexabromobiphenyl and 3,3′,4,4′,5,5′-Hexachlorobiphenyl on Hepatic Tumor Promotion in Rats

1989 ◽  
Vol 8 (6) ◽  
pp. 1201-1206 ◽  
Author(s):  
M. G. Evans ◽  
S. D. Sleight
Keyword(s):  
Dietary Exposure ◽  
Tumor Promotion ◽  
Inhibitory Effect ◽  
Sprague Dawley ◽  
Gamma Glutamyl Transpeptidase ◽  
Simultaneous Exposure ◽  
Activity Concentrations ◽  
Sprague Dawley Rats ◽  
System Tumor ◽  
Glutamyl Transpeptidase

Female Sprague-Dawley rats were partially hepatectomized, initiated with diethylnitrosamine (DEN), and fed diets containing 2,2′,4,4′,5,5′-hexabromobiphenyl (245-HBB), 3,3′,4,4′,5,5′-hexachlorobiphenyl (345-HCB), or combinations of 245-HBB and 345-HCB to determine the tumor-promoting ability of these compounds in a two-stage (initiation/promotion) hepatocar-cinogenesis system. Tumor-promoting ability was assessed by measuring hepatic foci positive for gamma glutamyl transpeptidase (GGT) activity. Concentrations of 10 or 100 mg 245-HBB/kg of diet caused significantly increased numbers of GGT-positive hepatic foci. When 245-HBB and 345-HCB were fed simultaneously, an additive effect on tumor-promoting ability was observed at dietary concentrations of 10 mg/kg 245-HBB and 0.1 mg/kg 345-HCB. However, an inhibitory effect on tumor promotion occurred when dietary concentrations of 100 mg/kg 245-HBB and 1.0 mg/kg 345-HCB were fed simultaneously. These results suggest that the tumor-promoting ability of simultaneous exposure to 245-HBB and 345-HCB can be additive or inhibitory depending upon the concentration of each congener in the diet.

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