scholarly journals Permeation-Enhancing Effect of Aloe-emodin Anthrone on Water-Soluble and Poorly Permeable Compounds in Rat Colonic Mucosa

2002 ◽  
Vol 25 (12) ◽  
pp. 1608-1613 ◽  
Author(s):  
Mamiko Kai ◽  
Kazutaka Hayashi ◽  
Ippei Kaida ◽  
Hatsumi Aki ◽  
Magobei Yamamoto
Keyword(s):  
Colonic Mucosa ◽  
Water Soluble ◽  
Enhancing Effect ◽  
Emodin Anthrone ◽  
Aloe Emodin

scholarly journals Partially hydrolysed guar gum ameliorates murine intestinal inflammation in association with modulating luminal microbiota and SCFA

2016 ◽  
Vol 116 (7) ◽  
pp. 1199-1205 ◽  
Author(s):  
Tomohisa Takagi ◽  
Yuji Naito ◽  
Yasuki Higashimura ◽  
Chihiro Ushiroda ◽  
Katsura Mizushima ◽  
...  
Keyword(s):  
Real Time ◽  
Intestinal Microbiota ◽  
Real Time Pcr ◽  
Colonic Mucosa ◽  
Guar Gum ◽  
Intestinal Inflammation ◽  
Neutrophil Infiltration ◽  
Water Soluble ◽  
Mucosal Inflammation ◽  
Trinitrobenzene Sulfonic Acid

AbstractPartially hydrolysed guar gum (PHGG), a water-soluble dietary fibre produced by the controlled partial enzymatic hydrolysis of guar gum beans, has various physiological roles. This study aimed to elucidate the beneficial effects of PHGG on colonic mucosal damage in a murine 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis model. Acute colitis was induced in male C57BL/6 mice with TNBS after 2 weeks of pre-feeding with PHGG (5 %). The colonic mucosal inflammation was evaluated using macroscopic damage scores, and neutrophil infiltration was assessed by measuring tissue-associated myeloperoxidase (MPO) activity in the colonic mucosa. TNF-αexpression in the colonic mucosa was measured by ELISA and real-time PCR. Moreover, the intestinal microbiota and production of SCFA were assessed by real-time PCR and HPLC, respectively. Colonic damage due to TNBS administration was significantly ameliorated by PHGG treatment. Furthermore, PHGG significantly inhibited increases in MPO activity and TNF-αprotein and mRNA expression in the colonic mucosa in TNBS-induced colitis. On analysis of intestinal microbiota, we found that the concentration of theClostridium coccoidesgroup (Clostridiumcluster XIVa), theClostridium leptumsubgroup (Clostridiumcluster IV) and theBacteroides fragilisgroup had significantly increased in PHGG-fed mice. On analysis of SCFA, we found that the caecal content of acetic acid, propionic acid and butyric acid had significantly increased in PHGG-fed mice. Together, these results suggest that chronic ingestion of PHGG prevents the development of TNBS-induced colitis in mice by modulating the intestinal microbiota and SCFA, which may be significant in the development of therapeutics for inflammatory bowel disease.

scholarly journals A Purgative Action of Barbaloin Is Induced by Eubacterium sp. Strain BAR, a Human Intestinal Anaerobe, Capable of Transforming Barbaloin to Aloe-Emodin Anthrone.

1996 ◽  
Vol 19 (1) ◽  
pp. 136-138 ◽  
Author(s):  
Teruaki AKAO ◽  
QingMing CHE ◽  
Kyoichi KOBASHI ◽  
Masao HATTORI ◽  
Tsuneo NAMBA
Keyword(s):  
Emodin Anthrone ◽  
Aloe Emodin

Syntheses of water-soluble [60]fullerene derivatives and their enhancing effect on neurite outgrowth in NGF-treated PC12 cells

2010 ◽  
Vol 20 (6) ◽  
pp. 1948-1952 ◽  
Author(s):  
Hiroki Tsumoto ◽  
Syo Kawahara ◽  
Yuki Fujisawa ◽  
Takayoshi Suzuki ◽  
Hidehiko Nakagawa ◽  
...  
Keyword(s):  
Neurite Outgrowth ◽  
Pc12 Cells ◽  
Water Soluble ◽  
Enhancing Effect ◽  
Fullerene Derivatives

Effects of Some Water-Soluble Contrast Media on the Colonic Mucosa

Radiology ◽  
1976 ◽  
Vol 118 (3) ◽  
pp. 545-548 ◽  
Author(s):  
Letty G. Lutzger ◽  
Stephen M. Factor
Keyword(s):  
Contrast Media ◽  
Colonic Mucosa ◽  
Water Soluble ◽  
Water Soluble Contrast
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