scholarly journals Metabolism of Ipecac Alkaloids Cephaeline and Emetine by Human Hepatic Microsomal Cytochrome P450s, and Their Inhibitory Effects on P450 Enzyme Activities.

2001 ◽  
Vol 24 (6) ◽  
pp. 678-682 ◽  
Author(s):  
Takayuki ASANO ◽  
Hirotaka KUSHIDA ◽  
Chiharu SADAKANE ◽  
Kazuhisa ISHIHARA ◽  
Yoko WAKUI ◽  
...  
Keyword(s):  
Enzyme Activities ◽  
Cytochrome P450s ◽  
Inhibitory Effects ◽  
Microsomal Cytochrome ◽  
P450 Enzyme

Microsomal cytochrome P450 enzyme activities in nonalcoholic steatohepatitis livers

2019 ◽  
Vol 34 (1) ◽  
pp. S25
Author(s):  
Maciej Czerwinski ◽  
Brian Oberheide ◽  
Nicholas Hatfield ◽  
Bill Ewy ◽  
Christopher Seib ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Nonalcoholic Steatohepatitis ◽  
Enzyme Activities ◽  
Cytochrome P450 Enzyme ◽  
Microsomal Cytochrome ◽  
P450 Enzyme ◽  
Microsomal Cytochrome P450

Inhibitory effects of astaxanthin, β-cryptoxanthin, canthaxanthin, lutein, and zeaxanthin on cytochrome P450 enzyme activities

2013 ◽  
Vol 59 ◽  
pp. 78-85 ◽  
Author(s):  
Yu Fen Zheng ◽  
Soo Hyeon Bae ◽  
Min Jo Kwon ◽  
Jung Bae Park ◽  
Hye Duck Choi ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Cytochrome P450 Enzyme ◽  
Inhibitory Effects ◽  
P450 Enzyme

Inhibitory Effects of Garcinia cambogia Extract on CYP2B6 Enzyme Activity

Planta Medica ◽  
2017 ◽  
Vol 83 (11) ◽  
pp. 895-900 ◽  
Author(s):  
Jun Yu ◽  
Min Choi ◽  
Jong Park ◽  
Shaheed Rehman ◽  
Katsunori Nakamura ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Liver Microsomes ◽  
Cytochrome P450 Enzyme ◽  
Dependent Manner ◽  
Cytochrome P450 Enzymes ◽  
Inhibitory Effects ◽  
Concentration Dependent Manner ◽  
Garcinia Cambogia ◽  
P450 Enzyme

AbstractThis study assessed the inhibitory effects of Garcinia cambogia extract on the cytochrome P450 enzymes in vitro. G. cambogia extract was incubated with cytochrome P450 isozyme-specific substrates in human liver microsomes and recombinant CYP2B6 isozyme, and the formation of the marker metabolites was measured to investigate the inhibitory potential on cytochrome P450 enzyme activities. The results showed that G. cambogia extract has significant inhibitory effects on CYP2B6 activity in a concentration-dependent manner. Furthermore, the inhibition was potentiated following preincubation with NADPH, indicating that G. cambogia extract is a time-dependent inhibitor of CYP2B6. Meanwhile, hydroxycitric acid, the major bioactive ingredient of G. cambogia extract, did not exhibit significant inhibition effects on cytochrome P450 enzyme activities. G. cambogia extract could modulate the pharmacokinetics of CYP2B6 substrate drugs and lead to interactions with those drugs. Therefore, caution may be required with respect to concomitant intake of dietary supplements containing G. cambogia extract with CYP2B6 substrates.

scholarly journals In Vivo Modulation of Rat Liver Microsomal Cytochrome P450 Activity by Antimalarial, Anti-HIV, and Antituberculosis Plant Medicines

2018 ◽  
Vol 23 ◽  
pp. 2515690X1881000 ◽  
Author(s):  
Regina Appiah-Opong ◽  
Isaac Tuffour ◽  
Ebenezer Ofori-Attah ◽  
Abigail Aning ◽  
Philip Atchoglo ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Drug Interactions ◽  
Rat Liver ◽  
Enzyme Activities ◽  
Cytochrome P450 Enzyme ◽  
Microsomal Cytochrome ◽  
P450 Enzyme ◽  
Microsomal Cytochrome P450 ◽  
Anti Hiv ◽  
Hiv Aids

Drug interactions are key reasons for adverse drug reactions and attrition from market. Major infectious diseases causing morbidity/mortality in Ghana are malaria, tuberculosis, and HIV/AIDS. In this study, plant medicines commonly used to treat/manage these diseases in Ghana were investigated for their potential to modulate rat cytochrome P450 enzyme activities. Fluorescence and high-performance liquid chromatography–based assays were used to assess effects of antimalarial plant medicines, Fever (FEV), Mal-TF (MAL), and Kantinka terric (KT); anti-TB medicines, Chestico (CHES), CA + ST Pains + HWNT (TF), and Kantinka herbatic (KHB); and anti-HIV/AIDS medicines, Wabco (WAB), AD + T/AD (LIV) and Kantinka BA (KBA) on rat liver microsomal cytochrome P450 enzyme activities. Effects of medicines on rat biochemical and hematological parameters were also assessed. Generally, the medicines altered microsomal CYP1A1/1A2, CYP2B1/2B2, CYP2C9, and CYP2D6 activities. Only KBA elicited an increase (80%) in CYP1A1/1A2 activity. FEV, MAL, CHES, WAB, and LIV strongly inhibited the enzyme activity. All the medicines significantly inhibited CYP2C9 (24%-80%) activity. CYP2D6 activity increased after treatment with MAL, KBA, LIV, and TF. Also, MAL, WAB, LIV, KHB, and CHES increased CYP2B1/2B2 activity, while KT decrease the activity. Generally, the medicines altered liver function in the rats. Cholesterol levels declined after KBA treatment only. White and red blood cell counts, hemoglobin and hematocrit levels were significantly reduced in KT- and KBA-treated rats. Our results suggest that use of the medicines could have implications for drug interactions and safety, particularly if the medicines are administered over prolonged periods. Further investigations are imperative to establish clinical relevance of these results.

Inhibitory effects of aschantin on cytochrome P450 enzyme activities in human liver microsomes

2017 ◽  
Vol 32 (1) ◽  
pp. S56
Author(s):  
Wongu Choi ◽  
Soon Sang Kwon ◽  
Tae Yeon Kong ◽  
Ju-Hyun Kim ◽  
Yong Yeon Cho ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Enzyme Activities ◽  
Human Liver ◽  
Liver Microsomes ◽  
Human Liver Microsomes ◽  
Cytochrome P450 Enzyme ◽  
Inhibitory Effects ◽  
P450 Enzyme
Sign in / Sign up

Export Citation Format

Share Document