scholarly journals Drug Targeting Efficacy to Underlying Muscle Following Topical Application. I. Evaluation Based on a Physiological Pharmacokinetic Model.

2000 ◽  
Vol 23 (7) ◽  
pp. 860-865 ◽  
Author(s):  
Tomomi HATANAKA ◽  
Eiichiro MANABE ◽  
Tomohiro OHTSUKI ◽  
Kaori OKUYAMA ◽  
Michinari MORI ◽  
...  
Keyword(s):  
Topical Application ◽  
Drug Targeting ◽  
Pharmacokinetic Model ◽  
Physiological Pharmacokinetic Model

Physiological pharmacokinetic model for ceftazidime disposition in the rat and its application to prediction of plasma concentrations in humans

1993 ◽  
Vol 1 (1) ◽  
pp. 3-11 ◽  
Author(s):  
Luis Granero ◽  
Jesús Chesa-Jiménez ◽  
Víctor Monserrat ◽  
Mercedes Almela ◽  
María-José Gimeno ◽  
...  
Keyword(s):  
Pharmacokinetic Model ◽  
Plasma Concentrations ◽  
Physiological Pharmacokinetic Model

scholarly journals A physiological pharmacokinetic model describing the disposition of lycopene in healthy men

2003 ◽  
Vol 44 (10) ◽  
pp. 1927-1939 ◽  
Author(s):  
Veda Diwadkar-Navsariwala ◽  
Janet A. Novotny ◽  
David M. Gustin ◽  
Jeffery A. Sosman ◽  
Keith A. Rodvold ◽  
...  
Keyword(s):  
Pharmacokinetic Model ◽  
Healthy Men ◽  
Physiological Pharmacokinetic Model

Adjusting Exposure Limits for Long and Short Exposure Periods Using A Physiological Pharmacokinetic Model

AIHAJ ◽  
1987 ◽  
Vol 48 (4) ◽  
pp. 335-343 ◽  
Author(s):  
MELVIN E. ANDERSEN ◽  
MICHAEL G. MacNAUGHTON ◽  
HARVEY J. CLEWELL III ◽  
DENNIS J. PAUSTENBACH
Keyword(s):  
Pharmacokinetic Model ◽  
Short Exposure ◽  
Exposure Limits ◽  
Physiological Pharmacokinetic Model

Physiological Pharmacokinetic Model of Hexachlorobenzene in the Rat

1989 ◽  
Vol 57 ◽  
pp. 139-147 ◽  
Author(s):  
R. A. Freeman ◽  
K. K. Rozman ◽  
A. G. E. Wilson
Keyword(s):  
Pharmacokinetic Model ◽  
Physiological Pharmacokinetic Model

Galactosylated proteins are recognized by the liver according to the surface density of galactose moieties

1995 ◽  
Vol 268 (5) ◽  
pp. G849-G856 ◽  
Author(s):  
M. Nishikawa ◽  
C. Miyazaki ◽  
F. Yamashita ◽  
Y. Takakura ◽  
M. Hashida
Keyword(s):  
Plasma Flow ◽  
Surface Density ◽  
Maximum Rate ◽  
Pharmacokinetic Model ◽  
Distribution Patterns ◽  
Hepatic Uptake ◽  
Michaelis Constant ◽  
Efficient Delivery ◽  
Uptake Process ◽  
Physiological Pharmacokinetic Model

The recognition of 111In-labeled galactosylated superoxide dismutase (Gal-SOD) and galactosylated bovine serum albumin (Gal-BSA) by the liver was investigated in mice after intravenous injection. 111In-labeled galactosylated proteins were recovered in the liver by amounts that were highly dependent on the degree of galactose modification and the administered dose. The distribution patterns were analyzed based on a physiological pharmacokinetic model including an uptake process with Michaelis-Menten kinetics in the liver and hepatic plasma flow. The Michaelis constant of hepatic uptake of 111In-Gal-SOD was observed to inversely correlate with the number of galactose residues, without a significant change in maximum rate of uptake or extrahepatic clearance. This relation could be applied to 111In-Gal-BSA and other galactosylated proteins by using the surface density of galactose residues as a degree of modification, suggesting galactose density controls ligand recognition by the asialoglycoprotein receptor. The analysis also indicated that increasing galactose density higher than 1.0 x 10(-3) molecules/A2 did not affect the distribution of galactosylated proteins due to limitation by the hepatic plasma flow rate. In conclusion, efficient delivery of proteins modified with galactose to the liver will be achieved by controlling both the galactose density on the protein surface and the administered dose.

Physiological pharmacokinetic model for distribution and elimination of pentazocine. II. Study in rabbits and scale-up to man

1984 ◽  
Vol 19 (1) ◽  
pp. 75-88 ◽  
Author(s):  
Ichimura Fujio ◽  
Yokogawa Koichi ◽  
Yamana Tsukinaka ◽  
Tsuji Akira ◽  
Yamamoto Ken ◽  
...  
Keyword(s):  
Pharmacokinetic Model ◽  
Scale Up ◽  
Physiological Pharmacokinetic Model
Sign in / Sign up

Export Citation Format

Share Document