scholarly journals Focal Cerebral Ischemia-Induced Escape Deficit in Rats Is Ameliorated by a Reversible Inhibitor of Monoamine Oxidase-A: Implications for a Novel Animal Model of Post-Stroke Depression.

2000 ◽  
Vol 23 (4) ◽  
pp. 406-410 ◽  
Author(s):  
Masaya KATO ◽  
Hiroshi IWATA ◽  
Masahito OKAMOTO ◽  
Taketoshi ISHII ◽  
Hiroshi NARITA
Keyword(s):  
Animal Model ◽  
Cerebral Ischemia ◽  
Monoamine Oxidase ◽  
Focal Cerebral Ischemia ◽  
Monoamine Oxidase A ◽  
Reversible Inhibitor ◽  
Post Stroke ◽  
Post Stroke Depression ◽  
Escape Deficit

scholarly journals A Strategic Application of Fast Fourier Transform as a Novel Tool to Evaluate the Extent of Neuronal Insult in Rat Model of Focal Cerebral Ischemia

2013 ◽  
Vol 5 (1) ◽  
pp. 29-36 ◽  
Author(s):  
S Paul ◽  
P Bhattacharya ◽  
AK Pandey ◽  
N Sharma ◽  
JP Tiwari ◽  
...  
Keyword(s):  
Mathematical Modeling ◽  
Animal Model ◽  
Spectral Analysis ◽  
Cerebral Ischemia ◽  
Rat Brain ◽  
Brain Function ◽  
Focal Cerebral Ischemia ◽  
Physiological State ◽  
Analysis Methods ◽  
Eeg Data

The present work envisages mathematical modeling of induced focal cerebral ischemia in animal model using EEG data with the help of Fast Fourier Transformation method. Amongst several analysis methods, spectral analysis methods are important because it detects the frequencies and characteristics changes of brain waveforms depending on the brain function affected from disorders and physiological state. There are many applications of FFT, and the most important being that it is one of the basic conventional spectral analysis methods. However, it has some limitations, for instance, it adds contributions in the low frequency region which are not present in the original signal, and necessitates the use of windowing for decreasing the error rate. The present analysis was undertaken to ensure actual correlation of the different mathematical paradigms. EEG data were obtained from different regions of rat brain and were processed by FFT modeling in MATLAB platform. The assessment of long lasting functional outcome and to prevalent classical approach to study stroke was necessitated and therefore highly recommended to evaluate the efficacy of therapeutic strategies in relation to EEG in animal model of brain stroke. This mathematical modeling specifically Power Spectrum Density analysis was done to correlate the different prevalent condition of rat brain function. DOI: http://dx.doi.org/10.3329/bjmp.v5i1.14666 Bangladesh Journal of Medical Physics Vol.5 No.1 2012 29-36

Studies on the animal model of post-stroke depression and application of antipsychotic aripiprazole

2015 ◽  
Vol 287 ◽  
pp. 294-303 ◽  
Author(s):  
Yu Ri Kim ◽  
Ha Neui Kim ◽  
Malk Eun Pak ◽  
Sung Min Ahn ◽  
Ki Hwan Hong ◽  
...  
Keyword(s):  
Animal Model ◽  
Post Stroke ◽  
Post Stroke Depression

scholarly journals Electroacupuncture Promotes Post-Stroke Functional Recovery via Enhancing Endogenous Neurogenesis in Mouse Focal Cerebral Ischemia

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e90000 ◽  
Author(s):  
Yu Ri Kim ◽  
Ha Neui Kim ◽  
Sung Min Ahn ◽  
Yung Hyun Choi ◽  
Hwa Kyoung Shin ◽  
...  
Keyword(s):  
Cerebral Ischemia ◽  
Functional Recovery ◽  
Focal Cerebral Ischemia ◽  
Post Stroke

scholarly journals Nimodipine in Animal Model Experiments of Focal Cerebral Ischemia

Stroke ◽  
2001 ◽  
Vol 32 (10) ◽  
pp. 2433-2438 ◽  
Author(s):  
J. Horn ◽  
R.J. de Haan ◽  
M. Vermeulen ◽  
P.G.M. Luiten ◽  
M. Limburg
Keyword(s):  
Animal Model ◽  
Cerebral Ischemia ◽  
Focal Cerebral Ischemia ◽  
Model Experiments

Rhamnocitrin isolated from Prunus padus var. seoulensis: A potent and selective reversible inhibitor of human monoamine oxidase A

2019 ◽  
Vol 83 ◽  
pp. 317-325 ◽  
Author(s):  
Seung Cheol Baek ◽  
Mi Hyeon Park ◽  
Hyung Won Ryu ◽  
Jae Pil Lee ◽  
Myung-Gyun Kang ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Monoamine Oxidase A ◽  
Reversible Inhibitor ◽  
Prunus Padus

Post-Stroke Fatigue May Be Associated with the Promoter Region of a Monoamine Oxidase A Gene Polymorphism

2016 ◽  
Vol 43 (1-2) ◽  
pp. 54-58 ◽  
Author(s):  
Smi Choi-Kwon ◽  
Mihye Ko ◽  
Sang-Eun Jun ◽  
Juhan Kim ◽  
Kyung-Hee Cho ◽  
...  
Keyword(s):  
Monoamine Oxidase ◽  
Promoter Region ◽  
Tryptophan Hydroxylase ◽  
Variable Number Tandem Repeat ◽  
Variable Number ◽  
Monoamine Oxidase A ◽  
Potential Contribution ◽  
Female Patients ◽  
Post Stroke ◽  
Mao A

Background: Post-stroke fatigue (PSF) is a common sequela of stroke. Despite reports of serotonergic involvement in the etiology of PSF, the potential contribution of serotonergic genes in the development of PSF needs to be investigated. Methods: A total of 373 patients, who experienced ischemic stroke for PSF, were evaluated 3 months after the stroke. PSF was assessed using the Fatigue Severity Scale. The genomic DNA collected and stored in a -70°C freezer was genotyped for 6 polymorphisms in genes associated with serotonin synthesis (tryptophan hydroxylase 1 (TPH1) A218C, TPH2 rs10879355, and TPH2 rs4641528), transport (the promoter region of the serotonin transporter protein), and catabolism (the 30-bp functional variable number tandem repeat) polymorphism in the promoter region of monoamine oxidase A (MAO-A). Results: Among the 373 patients, 164 (44%) had PSF. All patients were ethnic Koreans. Of the 6 polymorphisms examined, only one marker, that is, low-activity MAO-A was associated with PSF (p < 0.05) in female patients. Multiple logistic regression analyses showed that post-stroke depression (PSD; 95% CI 1.561-14.323, p = 0.006) and low MAO-A activity (95% CI 0.166-0.722, p = 0.005) were factors associated with PSF in female patients, whereas only PSD (95% CI 5.511-65.269, p = 0.000) was associated with PSF in male patients. Conclusions: Our findings suggest that PSF may be associated with a genetic polymorphism involving MAO-A, at least in female stroke patients.

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