scholarly journals Local Distribution into Brain Tumor and Pharmacokinetics of 4-Pyridoxate Diammine Hydroxy Platinum, a Novel Cisplatin Derivative, after Intracarotid Administration in Rats with 9L Malignant Glioma. Simultaneous Brain Microdialysis Study.

2000 ◽  
Vol 23 (12) ◽  
pp. 1491-1496 ◽  
Author(s):  
Yoshiharu TOKUNAGA ◽  
Mikiro NAKASHIMA ◽  
Hitoshi SASAKI ◽  
Naoki TOMIYAMA ◽  
Mihoko N. NAKASHIMA ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Malignant Glioma ◽  
Brain Microdialysis ◽  
Local Distribution ◽  
Microdialysis Study ◽  
Intracarotid Administration

Glioblastoma multiforme at the site of metal splinter injury: a coincidence?

1999 ◽  
Vol 91 (6) ◽  
pp. 1041-1044 ◽  
Author(s):  
Michael Sabel ◽  
Jörg Felsberg ◽  
Martina Messing-Jünger ◽  
Eva Neuen-Jacob ◽  
Jürgen Piek
Keyword(s):  
Brain Tumor ◽  
Glioblastoma Multiforme ◽  
Malignant Glioma ◽  
Causal Relationship ◽  
Propionibacterium Acnes ◽  
Glioma Tissue ◽  
Left Frontal Lobe ◽  
Content Type ◽  
Chronic Abscess ◽  
Fine Print

✓ The authors report the case of a man who had suffered a penetrating metal splinter injury to the left frontal lobe at 18 years of age. Thirty-seven years later the patient developed a left-sided frontal tumor at the precise site of the meningocerebral scar and posttraumatic defect. Histological examination confirmed a glioblastoma multiforme adjacent to the dural scar and metal splinters. In addition, a chronic abscess from which Propionibacterium acnes was isolated was found within the glioma tissue. The temporal and local association of metal splinter injury with chronic abscess, scar formation, and malignant glioma is highly suggestive of a causal relationship between trauma and the development of a malignant brain tumor.

Direct Delivery of Medication into a Brain Tumor through Multiple Chronically Implanted Catheters

Neurosurgery ◽  
1987 ◽  
Vol 20 (2) ◽  
pp. 286-291 ◽  
Author(s):  
Guy Bouvier ◽  
Richard D. Penn ◽  
Jeffrey S. Kroin ◽  
Rene Beique ◽  
Marie Jose Guerard
Keyword(s):  
Brain Tumor ◽  
Side Effects ◽  
Malignant Glioma ◽  
Catheter Removal ◽  
Recurrent Malignant Glioma ◽  
Osmotic Minipump ◽  
Catheter Implantation ◽  
Direct Delivery ◽  
Drug Solution ◽  
Tumor Area

Abstract A recurrent malignant glioma was treated with cisplatin delivered directly into the tumor. The drug was delivered via 68 small catheters distributed evenly throughout the tumor area. Each catheter was connected to an osmotic minipump that delivered 0.5 ml of drug solution each hour for 10 days. There were no side effects from the catheter implantation, chemotherapy, or catheter removal. Although the chemotherapy halted progression of the tumor, it recurred, and the patient died 6 months after treatment.

Abstract 4672: Phase I/II study of val-083 in patients with recurrent malignant glioma or secondary brain tumor.

2013 ◽  
Author(s):  
Dennis M. Brown ◽  
Jeffrey A. Bacha ◽  
William J. Garner ◽  
Kent C. Shih ◽  
Howard A. Burris ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Phase I ◽  
Malignant Glioma ◽  
Recurrent Malignant Glioma

scholarly journals Phase 1 trial of irinotecan (CPT-11) in patients with recurrent malignant glioma: A North American Brain Tumor Consortium study

2004 ◽  
Vol 6 (1) ◽  
pp. 44-54 ◽  
Author(s):  
Michael D. Prados ◽  
W.K.A. Yung ◽  
Kurt A. Jaeckle ◽  
H. Ian Robins ◽  
Minesh P. Mehta ◽  
...  
Keyword(s):  
Brain Tumor ◽  
Malignant Glioma ◽  
North American ◽  
Phase 1 ◽  
Recurrent Malignant Glioma ◽  
Phase 1 Trial

scholarly journals Radiotherapy induces an immediate inflammatory reaction in malignant glioma: a clinical microdialysis study

2016 ◽  
Vol 131 (1) ◽  
pp. 83-92 ◽  
Author(s):  
Pedram Tabatabaei ◽  
Eward Visse ◽  
Per Bergström ◽  
Thomas Brännström ◽  
Peter Siesjö ◽  
...  
Keyword(s):  
Malignant Glioma ◽  
Inflammatory Reaction ◽  
Microdialysis Study
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