scholarly journals Participation of Leukotriene D4 and Tumor Necrosis Factor on Lipopolysaccharide-Induced Airway Hyperresponsiveness in Guinea Pigs.

1997 ◽  
Vol 20 (4) ◽  
pp. 332-337 ◽  
Author(s):  
Takashi UNO ◽  
Hiroyuki TANAKA ◽  
Noriko NAKAI ◽  
Hiroichi NAGAI
Keyword(s):  
Tumor Necrosis Factor ◽  
Guinea Pigs ◽  
Airway Hyperresponsiveness ◽  
Tumor Necrosis ◽  
Leukotriene D4 ◽  
Necrosis Factor

scholarly journals Tumor Necrosis Factor Receptor 2 Contributes to Ozone-induced Airway Hyperresponsiveness in Mice

2001 ◽  
Vol 164 (4) ◽  
pp. 602-607 ◽  
Author(s):  
STEPHANIE A. SHORE ◽  
IGOR N. SCHWARTZMAN ◽  
BRIAN LE BLANC ◽  
G. G. KRISHNA MURTHY ◽  
CLAIRE M. DOERSCHUK
Keyword(s):  
Tumor Necrosis Factor ◽  
Airway Hyperresponsiveness ◽  
Tumor Necrosis ◽  
Tumor Necrosis Factor Receptor ◽  
Necrosis Factor

scholarly journals Vγ1+ T Cells and Tumor Necrosis Factor-Alpha in Ozone-Induced Airway Hyperresponsiveness

2009 ◽  
Vol 40 (4) ◽  
pp. 454-463 ◽  
Author(s):  
Shigeki Matsubara ◽  
Katsuyuki Takeda ◽  
Niyun Jin ◽  
Masakazu Okamoto ◽  
Hiroyuki Matsuda ◽  
...  
Keyword(s):  
T Cells ◽  
Tumor Necrosis Factor ◽  
Tumor Necrosis Factor Alpha ◽  
Airway Hyperresponsiveness ◽  
Tumor Necrosis ◽  
Necrosis Factor Alpha ◽  
Factor Alpha ◽  
Necrosis Factor

Tumor necrosis factor inhibits a polymorphonuclear leukocyte-dependent airway edema in guinea pigs

1988 ◽  
Vol 64 (4) ◽  
pp. 1688-1692 ◽  
Author(s):  
T. Gordon ◽  
D. Sheppard
Keyword(s):  
Tumor Necrosis Factor ◽  
Evans Blue ◽  
Polymorphonuclear Leukocyte ◽  
Guinea Pigs ◽  
Tumor Necrosis ◽  
Toluene Diisocyanate ◽  
Blue Dye ◽  
Evans Blue Dye ◽  
Airway Edema ◽  
Necrosis Factor

Intravenously administered endotoxin inhibits the polymorphonuclear leukocyte (PMN)-dependent airway edema produced in guinea pigs exposed to toluene diisocyanate (TDI). Tumor necrosis factor (TNF) is produced in vivo by peripheral blood monocytes and tissue macrophages stimulated with endotoxin and has been shown to activate PMN's and vascular endothelial cells. To determine whether the inhibition of airway edema is mediated by TNF, guinea pigs were treated with intravenous saline or 75,000 U/kg recombinant human TNF 1.5 h before exposure to air or 3 ppm TDI for 1 h. Animals were then injected intravenously with 50 mg/kg Evans blue dye as a marker of protein extravasation. Saline-treated animals exposed to TDI had a significant increase in tracheal Evans blue dye extravasation (85 +/- 6.5 micrograms dye/g trachea, mean +/- SE) compared with saline-treated animals exposed to air (31.3 +/- 2.5, P less than 0.001). The tracheal extravasation of Evans blue dye was significantly inhibited (P less than 0.05) in TDI-exposed animals treated with TNF (64.7 +/- 7.5). Neither heat-inactivated TNF (104.9 +/- 9.5) nor TNF neutralized with a monoclonal antibody against TNF (99.7 +/- 17.9) inhibited TDI-induced airway edema. In addition, treatment with 15,000 U/kg (99.9 +/- 21.3) or 150,000 U/kg (103.2 +/- 17.6) interleukin 1, a monokine also produced in response to endotoxin, did not prevent airway edema. These results suggest that TNF released in response to endotoxin mediates endotoxin's inhibition of a PMN-dependent airway edema.

Granulocyte Depletion Prevents Tumor Necrosis Factor-mediated Acute Lung Injury in Guinea Pigs

1988 ◽  
Vol 138 (5) ◽  
pp. 1300-1307 ◽  
Author(s):  
Kenton E. Stephens ◽  
Akitoshi Ishizaka ◽  
Zhaohan Wu ◽  
James W. Larrick ◽  
Thomas A. Raffin
Keyword(s):  
Acute Lung Injury ◽  
Tumor Necrosis Factor ◽  
Lung Injury ◽  
Guinea Pigs ◽  
Tumor Necrosis ◽  
Necrosis Factor
Sign in / Sign up

Export Citation Format

Share Document