scholarly journals Stimulation of Nitric Oxide-Cyclic GMP Pathway by L-Arginine Increases the Release of Hepatic Lipase from Cultured Rat Hepatocytes

1996 ◽  
Vol 19 (10) ◽  
pp. 1371-1373 ◽  
Author(s):  
Tetsuo MORITA ◽  
Yuko SHIMADA ◽  
Hiroshi UEKI ◽  
Asako KANAGAWA
Keyword(s):  
Nitric Oxide ◽  
Cyclic Gmp ◽  
Hepatic Lipase ◽  
Rat Hepatocytes ◽  
Cultured Rat Hepatocytes ◽  
Stimulation Of

Cell-Density-Dependent Release of Hepatic Lipase from Cultured Rat Hepatocytes

1989 ◽  
Vol 21 (01) ◽  
pp. 4-7 ◽  
Author(s):  
E. Jensen ◽  
P. Hansson ◽  
C.-H. Florén ◽  
Å Nilsson ◽  
P. Nilsson-Ehle
Keyword(s):  
Cell Density ◽  
Hepatic Lipase ◽  
Rat Hepatocytes ◽  
Density Dependent ◽  
Cultured Rat Hepatocytes

scholarly journals Induction of mRNA for phosphoenolpyruvate carboxykinase (GTP) by dexamethasone in cultured rat hepatocytes requires on-going protein synthesis

1987 ◽  
Vol 246 (1) ◽  
pp. 237-240 ◽  
Author(s):  
V L Nebes ◽  
S M Morris
Keyword(s):  
Phosphoenolpyruvate Carboxykinase ◽  
Rat Hepatocytes ◽  
Serum Free Medium ◽  
Free Medium ◽  
Serum Free ◽  
Maximum Induction ◽  
Cultured Rat Hepatocytes ◽  
Time Required ◽  
Necessary And Sufficient ◽  
Stimulation Of

Dexamethasone is necessary and sufficient to induce mRNA for phosphoenolpyruvate carboxykinase (GTP) (PEPCK) by 19-fold in rat hepatocytes cultured in serum-free medium. However, the time required for maximum induction is 16 h. The slow induction suggested that glucocorticoids regulate the expression of an intermediate gene product(s) which is required for glucocorticoid stimulation of PEPCK-gene expression. Consistent with this notion was the finding that cycloheximide completely blocked the response to dexamethasone. In contrast, cycloheximide did not block the response to a cyclic AMP analogue.

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