scholarly journals Theoretical Relationship between the Post-administration Time and Plasma or Urinary Concentration of a Metabolite and the Unchanged Drug Administration of Caffeine to Horses.

1996 ◽  
Vol 19 (10) ◽  
pp. 1341-1346 ◽  
Author(s):  
Sugako ARAMAKI ◽  
Osamu ISHIDAKA ◽  
Etsuko SUZUKI ◽  
Atsushi MOMOSE ◽  
Koshiro UMEMURA
Keyword(s):  
Drug Administration ◽  
Urinary Concentration ◽  
Unchanged Drug ◽  
Theoretical Relationship ◽  
Administration Time

Radioimmunoassay for bupropion in human plasma: comparison of tritiated and iodinated radioligands.

1983 ◽  
Vol 29 (3) ◽  
pp. 462-465 ◽  
Author(s):  
R F Butz ◽  
P G Smith ◽  
D H Schroeder ◽  
J W Findlay
Keyword(s):  
Polyethylene Glycol ◽  
Human Plasma ◽  
Drug Administration ◽  
Separation Method ◽  
Potential Usefulness ◽  
Oral Drug ◽  
Pharmacokinetic Studies ◽  
Plasma Samples ◽  
Unchanged Drug ◽  
Suitable Alternative

Abstract We evaluated the potential usefulness of 125I-labeled p-hydroxybupropion in a direct radioimmunoassay for bupropion in human plasma as compared with a currently used [3H]bupropion dextran-coated charcoal method. In both radioimmunoassay methods succinoylpropylbupropion antiserum was used that was highly specific for unchanged drug, cross reactivities with known bupropion metabolites being less than 0.3%. However, the use of 125I-labeled p-hydroxybupropion afforded greater sensitivity (0.3 microgram/L vs 0.6 microgram/L with [3H]bupropion) and was readily adaptable to the more convenient polyethylene glycol separation method. Between-assay CVs were 3.8 to 12.2% (mean 7.6%) with the 125I-based radioimmunoassay and 5.1 to 11.5% (mean 7.5%) with the 3H-based assay. Agreement between the two radioimmunoassay determinations of buproprion in human plasma samples collected over a 60-h period after oral drug administration was excellent (slope = 1.086, r = 0.989). We find the 125I-based assay a convenient and suitable alternative to the [3H]bupropion assay in pharmacokinetic studies in humans.

scholarly journals Mass drug administration: time to consider drug pollution?

The Lancet ◽  
2020 ◽  
Vol 395 (10230) ◽  
pp. 1112-1113 ◽  
Author(s):  
Gorka Orive ◽  
Unax Lertxundi
Keyword(s):  
Drug Administration ◽  
Mass Drug Administration ◽  
Administration Time
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