scholarly journals Inhibitory Effects of Cucurbitane Triterpenoids on Epstein-Barr Virus Activation and Two-Stage Carcinogenesis of Skin Tumors.

1994 ◽  
Vol 17 (5) ◽  
pp. 668-671 ◽  
Author(s):  
Takao KONOSHIMA ◽  
Midori TAKASAKI ◽  
Takeshi TATSUMOTO ◽  
Mutsuo KOZUKA ◽  
Ryoji KASAI ◽  
...  
2000 ◽  
Vol 154 (1) ◽  
pp. 101-105 ◽  
Author(s):  
Yukiko Iwase ◽  
Yuko Takemura ◽  
Motoharu Ju-ichi ◽  
Chihiro Ito ◽  
Hiroshi Furukawa ◽  
...  

1995 ◽  
Vol 18 (2) ◽  
pp. 284-287 ◽  
Author(s):  
Takao KONOSHIMA ◽  
Midori TAKASAKI ◽  
Mutsuo KOZUKA ◽  
Tsuneatsu NAGAO ◽  
Hikaru OKABE ◽  
...  

2001 ◽  
Vol 173 (2) ◽  
pp. 105-109 ◽  
Author(s):  
Yukiko Iwase ◽  
Yuko Takemura ◽  
Motoharu Ju-ichi ◽  
Teruo Mukainaka ◽  
Eiichiro Ichiishi ◽  
...  

1993 ◽  
Vol 68 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Ichiro Honda ◽  
Harukuni Tokuda ◽  
Mutsuo Kozuka ◽  
Koichi Yoneyama ◽  
Hoyoku Nishino ◽  
...  

2003 ◽  
Vol 66 (12) ◽  
pp. 1582-1585 ◽  
Author(s):  
Kenji Iwatsuki ◽  
Toshihiro Akihisa ◽  
Harukuni Tokuda ◽  
Motohiko Ukiya ◽  
Manabu Oshikubo ◽  
...  

1988 ◽  
Vol 51 (6) ◽  
pp. 1266-1270 ◽  
Author(s):  
Takao Konoshima ◽  
Emiko Okamoto ◽  
Mutsuo Kozuka ◽  
Hoyoku Nishino ◽  
Harukuni Tokuda ◽  
...  

2000 ◽  
Vol 78 (1) ◽  
pp. 31-40 ◽  
Author(s):  
Hironori Ohtsu ◽  
Reiko Tanaka ◽  
Yasuko In ◽  
Shunyo Matsunaga ◽  
Harukuni Tokuda ◽  
...  

A new podocarpane diterpene, 7α,15-dihydroxypodocarp-8(14)-en-13-one (1) and eight new abietane diterpenes, abiet-8(14)-en-7α,13β,15,18-tetraol (2), 7α,13β,15-trihydroxyabiet-8(14)-en-18-oic acid (3), 13β,18-dihydroxyabiet-8(14)-en-7-one (4), 13β,15,18-trihydroxyabiet-8(14)-en-7-one (5), 7-oxo-13β-methoxyabiet-8(14)- en-18-oic acid (7), abiet-8(14)-en-7α,12α,13β,18-tetraol (8), 7α,12α,13β-trihydroxyabiet-8(14)-en-18-oic acid (9), and abiet-8(14)-en-7α,12α,13β,15,18-pentaol (10) were isolated from the CHCl3 extract of the cones of Larix kaempferi. Their structures were determined on the basis of chemical and spectral evidence. The inhibitory effects of compounds 1-4 and 7-9 on Epstein-Barr virus early antigen (EBV-EA) activation induced by the tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), were examined for a primary screening for anti-tumor promotors. Key words: Larix kaempferi, Pinaceae, cones, abietane, EBV-EA.


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