scholarly journals Stimulatory Release of Hepatic Lipase Activity from Cultured Rat Hepatocytes by Sodium Orthovanadate: Rapid Increase in Cyclic Adenosine Monophosphate Content.

1994 ◽  
Vol 17 (5) ◽  
pp. 577-580 ◽  
Author(s):  
Tetsuo MORITA ◽  
Kouji SAKATA ◽  
Asako KANAGAWA ◽  
Hiroshi UEKI
2006 ◽  
Vol 52 (1) ◽  
pp. 85-90 ◽  
Author(s):  
Hisashi Tagashira ◽  
Rie Kerakawati ◽  
Toshio Motoyashiki ◽  
Tetsuo Morita

2000 ◽  
Vol 23 (5) ◽  
pp. 549-554
Author(s):  
Tetsuo MORITA ◽  
Akira FUJIWARA ◽  
Hiroshi UEKI ◽  
Asako KANAGAWA

Endocrinology ◽  
2004 ◽  
Vol 145 (11) ◽  
pp. 5364-5372 ◽  
Author(s):  
Eric D. Bruder ◽  
Ping C. Lee ◽  
Hershel Raff

Abstract Neonatal hypoxia is a common condition resulting from pulmonary and/or cardiac dysfunction. Dexamethasone therapy is a common treatment for many causes of neonatal distress, including hypoxia. The present study examined the effects of dexamethasone treatment on both normoxic and hypoxic neonatal rats. We performed comprehensive hepatic fatty acid/lipid profiling and evaluated changes in pertinent plasma hormones and lipids and a functional hepatic correlate, i.e. hepatic lipase activity. Rats were exposed to hypoxia from birth to 7 d of age. A 4-d tapering dose regimen of dexamethasone was administered on: postnatal day (PD)3 (0.5 mg/kg), PD4 (0.25 mg/kg), PD5 (0.125 mg/kg), and PD6 (0.05 mg/kg). The most significant finding was that dexamethasone attenuated nearly all hypoxia-induced changes in hepatic lipid profiles. Hypoxia increased the concentration of hepatic triacylglyceride and free fatty acids and, more specifically, increased a number of fatty acid metabolites within these lipid classes. Administration of dexamethasone blocked these increases. Hypoxia alone increased the plasma concentration of cholesterol and triacylglyceride, had no effect on plasma glucose, and only tended to increase plasma insulin. Dexamethasone administration to hypoxic pups resulted in an additional increase in plasma lipid concentrations, an increase in insulin, and a decrease in plasma glucose. Hypoxia and dexamethasone treatment each decreased total hepatic lipase activity. Normoxic pups treated with dexamethasone displayed increased plasma lipids and insulin. The effects of dexamethasone on hepatic function in the hypoxic neonate are dramatic and have significant implications in the assessment and treatment of metabolic dysfunction in the newborn.


2005 ◽  
Vol 81 (4) ◽  
pp. 911-915 ◽  
Author(s):  
Griët Bos ◽  
Jacqueline M Dekker ◽  
Edith JM Feskens ◽  
Marga C Ocke ◽  
Giel Nijpels ◽  
...  

2007 ◽  
Vol 55 (4) ◽  
pp. 187-194 ◽  
Author(s):  
Jacob J. Clarenbach ◽  
Gloria Lena Vega ◽  
Beverley Adams-Huet ◽  
Robert V. Considine ◽  
Madia Ricks ◽  
...  

1994 ◽  
Vol 109 (1-2) ◽  
pp. 61
Author(s):  
A. Mitchell ◽  
P.L. Griffiths ◽  
N.H. Fidge

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