scholarly journals Modification of Delipidated Apoprotein B of Low Density Lipoprotein by Lipid Oxidation Products in Relation to Macrophage Scavenger Receptor Binding.

1994 ◽  
Vol 17 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Manuel ALAIZ ◽  
Masatoshi BEPPU ◽  
Kenji OHISHI ◽  
Kiyomi KIKUGAWA
Keyword(s):  
Lipid Oxidation ◽  
Receptor Binding ◽  
Low Density Lipoprotein ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Oxidation Products ◽  
Low Density ◽  
Macrophage Scavenger Receptor ◽  
Lipid Oxidation Products ◽  
Apoprotein B

Differential PDGF secretion by graft and aortic SMC in response to oxidized LDL

2002 ◽  
Vol 283 (2) ◽  
pp. H725-H732 ◽  
Author(s):  
Afaf Absood ◽  
Akira Furutani ◽  
Tsutomu Kawamura ◽  
Linda M. Graham
Keyword(s):  
Oxidative Stress ◽  
Lipid Oxidation ◽  
Oxidized Ldl ◽  
Low Density Lipoprotein ◽  
Vascular Grafts ◽  
Density Lipoprotein ◽  
Oxidation Products ◽  
Enzyme Linked Immunosorbent Assay ◽  
Oxidized Low Density Lipoprotein ◽  
Lipid Oxidation Products

Smooth muscle cells (SMC) from prosthetic vascular grafts constitutively secrete higher levels of platelet-derived growth factor-AA (PDGF-AA) than aortic SMC. Lipid oxidation products accumulate in grafts and may stimulate PDGF production. The effect of oxidized low-density lipoprotein (oxLDL) on PDGF-AA secretion by aortic and graft SMC was compared. SMC isolated from canine thoracic aorta or Dacron thoracoabdominal grafts ( n = 10) were incubated with native LDL or oxLDL (0–400 μg/ml) for 72 h. PDGF-AA in the conditioned medium was measured with enzyme-linked immunosorbent assay. OxLDL increased PDGF-AA production by graft SMC from 78 ± 2 to 256 ± 16 pg PDGF/μg DNA and aortic SMC from 21 ± 1 to 40 ± 2 pg PDGF/μg DNA. Native LDL had no effect. N-acetylcysteine inhibited oxLDL-induced PDGF increase. Both superoxide and H2O2 stimulated PDGF secretion by graft SMC had little effect on aortic SMC. Our results suggest that PDGF production by graft (synthetic) SMC is more sensitive to stimulation by oxidative stress than aortic (contractile) SMC. Lipid oxidation products that accumulate in prosthetic vascular grafts can cause an oxidative stress, which stimulates PDGF production by graft SMC. PDGF can induce migration of aortic SMC onto the graft, contributing to the development of intimal hyperplasia.

scholarly journals Peroxynitrite modification of low-density lipoprotein leads to recognition by the macrophage scavenger receptor

FEBS Letters ◽  
1993 ◽  
Vol 330 (2) ◽  
pp. 181-185 ◽  
Author(s):  
Annette Graham ◽  
Neil Hogg ◽  
Balaraman Kalyanaraman ◽  
Vanessa O'Leary ◽  
Victor Darley-Usmar ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Low Density ◽  
Macrophage Scavenger Receptor

scholarly journals Synthethic collagen-like domain derived from the macrophage scavenger receptor binds acetylated low-density lipoprotein in vitro

1996 ◽  
Vol 9 (3) ◽  
pp. 307-313 ◽  
Author(s):  
Toshiki Tanaka ◽  
Akemi Nishikawa ◽  
Yuji Tanaka ◽  
Haruki Nakamura ◽  
Tatuhiko Kodama ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Scavenger Receptor ◽  
Density Lipoprotein ◽  
Low Density ◽  
Macrophage Scavenger Receptor
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