scholarly journals Dual Modes of Action of Platelet-Derived Growth Factor and Its Inhibition by Trichostatin-A for DNA Synthesis in Primary Cultured Smooth Muscle Cells of Rat Aorta.

1994 ◽  
Vol 17 (3) ◽  
pp. 399-402 ◽  
Author(s):  
Masayasu KIMURA ◽  
Ikuko KIMURA ◽  
Motonori OKABE ◽  
Teruhiko BEPPU
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Smooth Muscle Cells ◽  
Dna Synthesis ◽  
Trichostatin A ◽  
Muscle Cells ◽  
Rat Aorta ◽  
Platelet Derived Growth Factor ◽  
Modes Of Action ◽  
Cultured Smooth Muscle Cells

Vasoconstriction: a new activity for platelet-derived growth factor

Science ◽  
1986 ◽  
Vol 232 (4746) ◽  
pp. 87-90 ◽  
Author(s):  
BC Berk ◽  
RW Alexander ◽  
TA Brock ◽  
MA Gimbrone ◽  
RC Webb
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Rat Aorta ◽  
Platelet Derived Growth Factor ◽  
Free Calcium ◽  
Free Calcium Concentration ◽  
Cytosolic Free Calcium Concentration

Platelet-derived growth factor (PDGF) is a potent mitogen for vascular smooth muscle cells that has been implicated in the pathogenesis of atherosclerosis. The potential role of PDGF in the altered vasoreactivity of atherosclerotic vessels has been studied through an examination of its effects on contractility in the rat aorta. PDGF caused a concentration-dependent contraction of aortic strips and was significantly more potent on a molar basis than the classic vasoconstrictor peptide angiotensin II. Furthermore, PDGF increased the cytosolic free calcium concentration in cultured rat aortic smooth muscle cells. These observations suggest a new biological activity for PDGF that may contribute to the enhanced vasoreactivity of certain atherosclerotic vessels.

scholarly journals Cholesterol Enhances Platelet-Derived Growth Factor-BB-Induced [Ca 2+ ] i and DNA Synthesis in Rat Aortic Smooth Muscle Cells

Hypertension ◽  
1997 ◽  
Vol 29 (1) ◽  
pp. 326-333 ◽  
Author(s):  
Agapios Sachinidis ◽  
Min Liu ◽  
Artur-Aron Weber ◽  
Claudia Seul ◽  
Volker Harth ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Growth Factor ◽  
Smooth Muscle Cells ◽  
Dna Synthesis ◽  
Muscle Cells ◽  
Platelet Derived Growth Factor ◽  
Aortic Smooth Muscle Cells ◽  
Aortic Smooth Muscle
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