scholarly journals Hormonal Regulation of Tyrosine Aminotransferase and Phenylalanine Hydroxylase in Rat Hepatoma Cells Continuously Cultured in a Serum-Free Medium.Effect of Serum, Dexamethasone and Insulin

1981 ◽  
Vol 6 (1) ◽  
pp. 61-68 ◽  
Author(s):  
Kenji Sorimachi ◽  
Akira Niwa ◽  
Yosihiro Yasumura
Keyword(s):  
Hormonal Regulation ◽  
Phenylalanine Hydroxylase ◽  
Tyrosine Aminotransferase ◽  
Hepatoma Cells ◽  
Serum Free ◽  
Rat Hepatoma ◽  
Rat Hepatoma Cells

Hormonal regulation of plasminogen activator in rat hepatoma cells

1983 ◽  
pp. 11-21
Author(s):  
Thomas D. Gelehrter ◽  
Patricia A. Barouski-Miller ◽  
Patrick L. Coleman ◽  
Bernard J. Cwikel
Keyword(s):  
Plasminogen Activator ◽  
Hormonal Regulation ◽  
Hepatoma Cells ◽  
Rat Hepatoma ◽  
Rat Hepatoma Cells

Control of angiotensinogen production by H4 rat hepatoma cells in serum-free culture

1988 ◽  
Vol 24 (7) ◽  
pp. 699-704 ◽  
Author(s):  
Masatoshi Togami ◽  
Daphne Blazka ◽  
Jun Hayashi
Keyword(s):  
Hepatoma Cells ◽  
Serum Free ◽  
Rat Hepatoma ◽  
Rat Hepatoma Cells

Glucocorticoid stimulation of tetrahydrobiopterin levels and phenylalanine hydroxylase activity in rat hepatoma cells

1989 ◽  
Vol 67 (6) ◽  
pp. 293-296 ◽  
Author(s):  
Michael A. Parniak ◽  
Janice Pilkington
Keyword(s):  
Culture Medium ◽  
Phenylalanine Hydroxylase ◽  
Hepatoma Cells ◽  
Rapid Loss ◽  
Maximum Elevation ◽  
Rat Liver Cells ◽  
Important Regulator ◽  
Rat Hepatoma ◽  
Rat Hepatoma Cells ◽  
Stimulation Of

Incubation of H4-II-E-C3 rat hepatoma cells with either hydrocortisone or dexamethasone resulted in 3- to 5-fold increases in the levels of both phenylalanine hydroxylase and its essential cofactor, tetrahydrobiopterin. Maximum elevation of phenylalanine hydroxylase was noted after 24 h of incubation, whereas significant increases in tetrahydrobiopterin were found only after 48 h exposure of the cells to glucocorticoids. Removal of hormone from the culture medium resulted in rapid loss of cell tetrahydrobiopterin, but a much slower decline in the level of phenylalanine hydroxylase. Thus, although the levels of both phenylalanine hydroxylase and tetrahydrobiopterin in rat hepatoma cells are regulated by glucocorticoids, this regulation is apparently not strictly coordinated. Nevertheless, control of cellular tetrahydrobiopterin levels may be an important regulator of hepatic phenylalanine catabolism since significant increases in the ability of intact rat liver cells to hydroxylate phenylalanine were observed only after 48 h exposure to glucocorticoids, in correlation with increases in cell tetrahydrobiopterin content.Key words: phenylalanine hydroxylase, tetrahydrobiopterin, glucocorticoid, hepatoma cells.

scholarly journals Hormonal regulation of plasminogen activator in rat hepatoma cells

1983 ◽  
Vol 53-54 (1-2) ◽  
Author(s):  
ThomasD. Gelehrter ◽  
PatriciaA. Barouski-Miller ◽  
PatrickL. Coleman ◽  
BernardJ. Cwikel
Keyword(s):  
Plasminogen Activator ◽  
Hormonal Regulation ◽  
Hepatoma Cells ◽  
Rat Hepatoma ◽  
Rat Hepatoma Cells
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