scholarly journals Synchrony of Burkitt Lymphoma Cells Induced by Hydroxyurea

1976 ◽  
Vol 1 (2) ◽  
pp. 177-185
Author(s):  
Tadaaki Miyamoto ◽  
Michinori Watanabe ◽  
Yosinobu Takabe ◽  
Toyozo Terasima
Keyword(s):  
Burkitt Lymphoma ◽  
Lymphoma Cells

Selective serotonin reuptake inhibitors directly signal for apoptosis in biopsy-like Burkitt lymphoma cells

Blood ◽  
2003 ◽  
Vol 101 (8) ◽  
pp. 3212-3219 ◽  
Author(s):  
Adamantios Serafeim ◽  
Michelle J. Holder ◽  
Gillian Grafton ◽  
Anita Chamba ◽  
Mark T. Drayson ◽  
...  
Keyword(s):  
Burkitt Lymphoma ◽  
Serotonin Reuptake ◽  
Selective Serotonin Reuptake Inhibitors ◽  
Mononuclear Cells ◽  
Serotonin Reuptake Inhibitors ◽  
Calcium Flux ◽  
Selective Serotonin ◽  
Future Application ◽  
Lymphoma Cells ◽  
Normal Peripheral Blood

Abstract Selective serotonin reuptake inhibitors (SSRIs) are the treatment of choice for clinical depression and a range of anxiety-related disorders. They are well tolerated over extended periods with more than 50 million people worldwide benefiting from their use. Here we show that 3 structurally distinct SSRIs—fluoxetine, paroxetine, and citalopram—act directly on Burkitt lymphoma (BL) cells to trigger rapid and extensive programmed cell death. SSRIs unexpectedly stimulated calcium flux, tyrosine phosphorylation, and down-regulation of the c-myc and nm23 genes in Burkitt lymphoma cells remaining faithful to the biopsy phenotype. Resultant SSRI-induced apoptosis was preceded by caspase activation, poly(ADP-ribose) polymerase-1 (PARP-1) cleavage, DNA fragmentation, a loss of mitochondrial membrane potential, and the externalization of phosphatidylserine, and reversed by the overexpression of bcl-2. Normal peripheral blood mononuclear cells and tonsil B cells, whether resting or stimulated into cycle, were largely resistant to SSRI-induced death as were 5 non-BL lymphoid cell lines tested. We discuss these findings within the context of whether the SSRI class of antidepressants could find future application as potential therapeutics for the highly aggressive and—because of its association with AIDS—increasingly more common Burkitt lymphoma.

Effect of centrifugation on the viability of Burkitt lymphoma cells

1968 ◽  
Vol 10 (5) ◽  
pp. 641-649 ◽  
Author(s):  
Daniel I. C. Wang ◽  
Tony J. Sinskey ◽  
Robert E. Gerner ◽  
Richard P. De Filippi
Keyword(s):  
Burkitt Lymphoma ◽  
Lymphoma Cells

Studies on Cell-Mediated Reactions against Cultured Burkitt Lymphoma Cells

2015 ◽  
pp. 818-827
Author(s):  
S. H. Golub ◽  
J. F. Hewetson ◽  
E. A. J. Svedmyr ◽  
G. Klein ◽  
S. Singh
Keyword(s):  
Burkitt Lymphoma ◽  
Lymphoma Cells

STAT3 mediates multidrug resistance of Burkitt lymphoma cells by promoting antioxidant feedback

2017 ◽  
Vol 488 (1) ◽  
pp. 182-188 ◽  
Author(s):  
Ruolan Zeng ◽  
Youhong Tang ◽  
Hui Zhou ◽  
Yiping Liu ◽  
Junhui Huang ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Burkitt Lymphoma ◽  
Lymphoma Cells

scholarly journals Japonicone A Suppresses Growth of Burkitt Lymphoma Cells through Its Effect on NF-κB

2013 ◽  
Vol 19 (11) ◽  
pp. 2917-2928 ◽  
Author(s):  
Xiaoguang Li ◽  
Xinying Yang ◽  
Yanling Liu ◽  
Nuoxi Gong ◽  
Wenbo Yao ◽  
...  
Keyword(s):  
Burkitt Lymphoma ◽  
Lymphoma Cells

Effect of Arginine Deficiency on Synthesis of DNA and Immunoglobulin Receptor of Burkitt Lymphoma Cells

Nature ◽  
1970 ◽  
Vol 227 (5256) ◽  
pp. 398-399 ◽  
Author(s):  
B. O. OSUNKOYA ◽  
W. H. ADLER ◽  
R. T. SMITH
Keyword(s):  
Burkitt Lymphoma ◽  
Lymphoma Cells ◽  
Immunoglobulin Receptor ◽  
Arginine Deficiency

Activation and somatic mutation of the translocated c-myc gene in Burkitt lymphoma cells

Cell ◽  
1984 ◽  
Vol 36 (2) ◽  
pp. 339-348 ◽  
Author(s):  
Rebecca Taub ◽  
Christopher Moulding ◽  
Jim Battey ◽  
William Murphy ◽  
Thomas Vasicek ◽  
...  
Keyword(s):  
Somatic Mutation ◽  
Burkitt Lymphoma ◽  
Lymphoma Cells ◽  
Myc Gene
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