Screening Anti-influenza Agents that Target Avian Influenza Polymerase Protein PACfrom Plant Extracts Based on NMR Methods

2011 ◽  
Vol 40 (8) ◽  
pp. 801-803 ◽  
Author(s):  
Lin Li ◽  
Sheng-Hai Chang ◽  
Jun-Feng Xiang ◽  
Qian Li ◽  
Huan-Huan Liang ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Plant Extracts ◽  
Nmr Methods ◽  
Influenza Polymerase

Magnesium-Dependent RNA Binding to the PA Endonuclease Domain of the Avian Influenza Polymerase

2014 ◽  
Vol 118 (4) ◽  
pp. 873-889 ◽  
Author(s):  
Shiyan Xiao ◽  
Michael L. Klein ◽  
David N. LeBard ◽  
Benjamin G. Levine ◽  
Haojun Liang ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Rna Binding ◽  
Endonuclease Domain ◽  
Influenza Polymerase

scholarly journals Mammalian ANP32A and ANP32B proteins drive alternative avian influenza virus polymerase adaptations

2020 ◽  
Author(s):  
Thomas. P. Peacock ◽  
Carol M. Sheppard ◽  
Ecco Staller ◽  
Rebecca Frise ◽  
Olivia C. Swann ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Avian Influenza ◽  
Avian Influenza Virus ◽  
Experimental Evolution ◽  
Human Cells ◽  
Influenza Viruses ◽  
Avian Viruses ◽  
Evolution Approach ◽  
Influenza Polymerase

AbstractANP32 proteins, which act as influenza polymerase co-factors, vary between birds and mammals. The well-known mammalian adaptation, PB2-E627K, enables influenza polymerase to use mammalian ANP32 proteins. However, some mammalian-adapted influenza viruses do not harbour this adaptation. Here, we show that alternative PB2 adaptations, Q591R and D701N also allow influenza polymerase to use mammalian ANP32 proteins. PB2-E627K strongly favours use of mammalian ANP32B proteins, whereas D701N shows no such bias. Accordingly, PB2-E627K adaptation emerges in species with strong pro-viral ANP32B proteins, such as humans and mice, while D701N is more commonly seen in isolates from swine, dogs and horses where ANP32A proteins are more strongly pro-viral. In an experimental evolution approach, passage of avian viruses in human cells drives acquisition of PB2-E627K, but not when ANP32B is ablated. The strong pro-viral support of ANP32B for PB2-E627K maps to the LCAR region of ANP32B.

Screening Potential Antitumor Agents from Natural Plant Extracts by G-Quadruplex Recognition and NMR Methods

2008 ◽  
Vol 120 (30) ◽  
pp. 5672-5674 ◽  
Author(s):  
Qiuju Zhou ◽  
Lin Li ◽  
Junfeng Xiang ◽  
Yalin Tang ◽  
Hong Zhang ◽  
...  
Keyword(s):  
Plant Extracts ◽  
Antitumor Agents ◽  
Natural Plant ◽  
G Quadruplex ◽  
Nmr Methods ◽  
Potential Antitumor

Screening Potential Antitumor Agents from Natural Plant Extracts by G-Quadruplex Recognition and NMR Methods

2008 ◽  
Vol 47 (30) ◽  
pp. 5590-5592 ◽  
Author(s):  
Qiuju Zhou ◽  
Lin Li ◽  
Junfeng Xiang ◽  
Yalin Tang ◽  
Hong Zhang ◽  
...  
Keyword(s):  
Plant Extracts ◽  
Antitumor Agents ◽  
Natural Plant ◽  
G Quadruplex ◽  
Nmr Methods ◽  
Potential Antitumor

Crystal structure of an avian influenza polymerase PAN reveals an endonuclease active site

Nature ◽  
2009 ◽  
Vol 458 (7240) ◽  
pp. 909-913 ◽  
Author(s):  
Puwei Yuan ◽  
Mark Bartlam ◽  
Zhiyong Lou ◽  
Shoudeng Chen ◽  
Jie Zhou ◽  
...  
Keyword(s):  
Crystal Structure ◽  
Avian Influenza ◽  
Active Site ◽  
Influenza Polymerase

scholarly journals Full Factorial Analysis of Mammalian and Avian Influenza Polymerase Subunits Suggests a Role of an Efficient Polymerase for Virus Adaptation

PLoS ONE ◽  
2009 ◽  
Vol 4 (5) ◽  
pp. e5658 ◽  
Author(s):  
Olive T. W. Li ◽  
Michael C. W. Chan ◽  
Cynthia S. W. Leung ◽  
Renee W. Y. Chan ◽  
Yi Guan ◽  
...  
Keyword(s):  
Avian Influenza ◽  
Factorial Analysis ◽  
Virus Adaptation ◽  
Full Factorial ◽  
Influenza Polymerase
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