Optical Resolution of Chiral Buckybowls by Chiral HPLC

2010 ◽  
Vol 39 (6) ◽  
pp. 646-647 ◽  
Author(s):  
Ryoji Tsuruoka ◽  
Shuhei Higashibayashi ◽  
Takeharu Ishikawa ◽  
Shinji Toyota ◽  
Hidehiro Sakurai
Keyword(s):  
Optical Resolution ◽  
Chiral Hplc

scholarly journals Direct Optical Resolution of Carboxylic Acids by Chiral HPLC on Tris(3,5-dimethylphenylcarbamate)s of Cellulose and Amylose

1988 ◽  
Vol 17 (7) ◽  
pp. 1125-1128 ◽  
Author(s):  
Yoshio Okamoto ◽  
Ryo Aburatani ◽  
Yuriko Kaida ◽  
Koichi Hatada
Keyword(s):  
Carboxylic Acids ◽  
Optical Resolution ◽  
Chiral Hplc

Optical resolution of ?-lactams by chiral HPLC on tris(phenylcarbamate)s of cellulose and amylose

Chirality ◽  
1989 ◽  
Vol 1 (3) ◽  
pp. 216-222 ◽  
Author(s):  
Yoshio Okamoto ◽  
Toshiaki Senoh ◽  
Harumi Nakane ◽  
Koichi Hatada
Keyword(s):  
Optical Resolution ◽  
Chiral Hplc

scholarly journals Deep-red circularly polarized luminescent C70 derivatives

2020 ◽  
Author(s):  
Haruka Kano ◽  
Hironobu Hayashi ◽  
Kyohei Matsuo ◽  
Michiya Fujiki ◽  
Hiroko Yamada ◽  
...  
Keyword(s):  
Chiral Recognition ◽  
Addition Reaction ◽  
Optical Resolution ◽  
Mirror Image ◽  
Chiral Hplc ◽  
Circularly Polarized ◽  
Circularly Polarized Luminescence ◽  
Polarized Luminescence ◽  
Nanocarbon Materials ◽  
One Step

Abstract Optically active fullerenes (C76, C82, C84), including C60 and C70 derivatives carrying organic substituents, possess various potent applications because of unique spectroscopic, catalytic, and chiral recognition properties. However, their inherent photoexcited chirality has not yet been elucidated because of a very poor quantum yield of fluorescence (FL). With this background in mind, we synthesized new chiral C70 derivatives, X70A, solely by reacting bis-borylated xanthene with C70 in a one-step double addition reaction with 20% yield, followed by a successful optical resolution using a recyclable chiral-HPLC technique. The isolated X70A enantiomers were confirmed by their mirror-image circular dichroism spectra in the range of 300 nm and 700 nm. The enantiomeric pair of X70A in toluene revealed clearly mirror-image circularly polarized luminescence (CPL) spectra with a high |glum| value of 7.0 × 10–3 at 690 nm associated with FL lifetime of 0.99 ns. The deep-red CPL of X70A should provide new photofunctionality as chiral nanocarbon materials.

scholarly journals New Enantiomers of a Nor-Bisabolane Derivative and Two New Phthalides Produced by the Marine-Derived Fungus Penicillium chrysogenum LD-201810

2021 ◽  
Vol 12 ◽  
Author(s):  
Yan Ge ◽  
Wen-Li Tang ◽  
Qing-Rong Huang ◽  
Mao-Lian Wei ◽  
You-Zhi Li ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Penicillium Chrysogenum ◽  
Optical Resolution ◽  
Alternaria Solani ◽  
2D Nmr ◽  
Chiral Hplc ◽  
Excellent Activity ◽  
Marine Algal ◽  
Detailed Interpretation ◽  
Mcf 7

Marine-derived fungi are a treasure house for the discovery of structurally novel secondary metabolites with potential pharmaceutical value. In this study, a pair of new nor-bisabolane derivative enantiomers (±)−1 and two new phthalides (4 and 5), as well as four known metabolites, were isolated from the culture filtrate of the marine algal-derived endophytic fungus Penicillium chrysogenum LD-201810. Their structures were established by detailed interpretation of spectroscopic data (1D/2D NMR and ESI-MS). The optical resolution of compound (±)−1 by chiral HPLC successfully afforded individual enantiomers (+)−1 and (−)−1, and their absolute configurations were determined by TDDFT-ECD calculations. Compound (±)−1 represents the first example of bisabolane analogs with a methylsulfinyl substituent group, which is rare in natural products. All of the isolated compounds 1–7 were evaluated for their cytotoxic activity against A549, BT-549, HeLa, HepG2, MCF-7, and THP-1 cell lines, as well as for antifungal activity against four plant pathogenetic fungi (Alternaria solani, Botrytis cinerea, Fusarium oxysporum, and Valsa mali). Compound 2, a bisabolane-type sesquiterpenoid, was shown to possess excellent activity for control of B. cinerea with half-maximal inhibitory concentration (IC50) of 13.6 μg/mL, whereas the remaining investigated compounds showed either weak or no cytotoxic/antifungal activity in this study.

Optical Resolution of Racemic Drugs by Chiral HPLC on Cellulose and Amylose Tris(phenylcarbamate) Derivatives

1988 ◽  
Vol 11 (9-10) ◽  
pp. 2147-2163 ◽  
Author(s):  
Yoshio Okamoto ◽  
Ryo Aburatani ◽  
Kazuhiro Hatano ◽  
Koichi Hatada
Keyword(s):  
Optical Resolution ◽  
Chiral Hplc

Synthesis of Axially Chiral 2,2’-Bisphosphobiarenes via a Nickel-Catalyzed Asymmetric Ullmann Coupling: General Access to Privileged Chiral Ligands without Optical Resolution

2020 ◽  
Author(s):  
Ziqing Zuo ◽  
Raphael Kim ◽  
Donald Watson
Keyword(s):  
Optical Resolution ◽  
Chiral Ligands ◽  
Chiral Auxiliaries ◽  
Axially Chiral ◽  
Ullmann Coupling

<div><p>We report an asymmetric Ullmann-type homocoupling of <i>ortho-</i>(iodo)arylphosphine oxides and <i>ortho</i>-(iodo)arylphosphonates that results in highly enantioenriched axially chiral bisphosphine oxides and bisphosphonates in good yields and excellent enantioselectivities. These products are readily converted to enantioenriched biaryl bisphosphines without need for chiral auxiliaries or optical resolution. This process provides a straightforward and practical route for the development of previously uninvestigated atroposelective biaryl bisphosphine ligands.</p></div>

Biocatalytic Ketone Reductions Using Biobeads

2020 ◽  
Author(s):  
Jia Shen Chew ◽  
Ken Chi Lik Lee ◽  
THI THANH NHA HO
Keyword(s):  
Enzyme Immobilization ◽  
High Throughput ◽  
High Throughput Screening ◽  
Chiral Hplc ◽  
Micro Scale

<p>Lee and coworkers offers a kind of new concept to enzyme immobilization and explores its suitability in the context of miniaturisation and high-throughput screening. Here, polystyrene-immobilized ketoreductases are compared with its non-immobilized counterparts in terms of conversion and stereoselectivity (both determined by chiral HPLC), and the study indicates that the BioBeads perform similarly (sometimes slightly more selective) which may be useful whenever defined micro-scale amounts of biocatalysts were required in high-throughput experiment settings.</p>

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