TEMPO-based Redox-sensitive Fluorescent Probes and Their Applications to Evaluating Intracellular Redox Status in Living Cells

2009 ◽  
Vol 38 (6) ◽  
pp. 588-589 ◽  
Author(s):  
Yang Liu ◽  
Shanlin Liu ◽  
Yanguang Wang
Keyword(s):  
Fluorescent Probes ◽  
Redox Status ◽  
Living Cells ◽  
Intracellular Redox Status ◽  
Intracellular Redox

scholarly journals Regulation of CD20 expression by radiation-induced changes in intracellular redox status

2008 ◽  
Vol 44 (4) ◽  
pp. 614-623 ◽  
Author(s):  
Damodar Gupta ◽  
Meredith E. Crosby ◽  
Alexandru Almasan ◽  
Roger M. Macklis
Keyword(s):  
Redox Status ◽  
Cd20 Expression ◽  
Radiation Induced ◽  
Induced Changes ◽  
Intracellular Redox Status ◽  
Intracellular Redox

scholarly journals PGK1 and p27/kip1 as Biomarkers for Intracellular Redox Status

2008 ◽  
Vol 22 (S1) ◽  
Author(s):  
Jong‐Sang Kim ◽  
Lesley Quintos ◽  
In Ae Lee ◽  
Ji Sun Lim ◽  
Ji Yeon Seo ◽  
...  
Keyword(s):  
Redox Status ◽  
P27 Kip1 ◽  
Intracellular Redox Status ◽  
Intracellular Redox

scholarly journals Intracellular redox status during acute coronary syndrome

2019 ◽  
Vol 11 (3) ◽  
pp. e358
Author(s):  
Sabah Gheddouchi ◽  
Nassima Mokhtari-Soulimane ◽  
Hafida Merzouk ◽  
Fayçal Soulimane ◽  
Fadia Bekhti ◽  
...  
Keyword(s):  
Acute Coronary Syndrome ◽  
Redox Status ◽  
Coronary Syndrome ◽  
Intracellular Redox Status ◽  
Intracellular Redox

scholarly journals Calcineurin expression and activity is regulated by the intracellular redox status and under hypertension in human neutrophils

2012 ◽  
Vol 214 (3) ◽  
pp. 399-408 ◽  
Author(s):  
Gonzalo Alba ◽  
Consuelo Santa-María ◽  
María Edith Reyes-Quiroz ◽  
Rajaa El Bekay ◽  
Isabel Geniz ◽  
...  
Keyword(s):  
De Novo ◽  
Redox Status ◽  
Human Neutrophils ◽  
Pyrrolidine Dithiocarbamate ◽  
Activity Levels ◽  
Ang Ii ◽  
Activity Increase ◽  
Expression And Activity ◽  
Intracellular Redox Status ◽  
Intracellular Redox

Calcineurin (protein phosphatase 2B) (CN) comprises a family of serine/threonine phosphatases that play a pivotal role in signal transduction cascades in a variety of cells, including neutrophils. Angiotensin II (Ang II) increases both activity andde novosynthesis of CN in human neutrophils. This study focuses on the role that intracellular redox status plays in the induction of CN activity by Ang II. Bothde novosynthesis of CN and activity increase promoted by Ang II were downregulated when cells were treated withl-buthionine-(S,R)-sulfoximine, an inhibitor of synthesis of the antioxidant glutathione. We have also investigated the effect of pyrrolidine dithiocarbamate and phenazine methosulfate, which are antioxidant and oxidant compounds, respectively, and concluded that the intracellular redox status of neutrophils is highly critical for Ang II-induced increase of CN expression and activity. Results obtained in neutrophils from hypertensive patients were very similar to those obtained in these cells on treatment with Ang II. We have also addressed the possible functional implication of CN activation in the development of hypertension. Present findings indicate that downregulation of hemoxygenase-1 expression in neutrophils from hypertensive subjects is likely mediated by CN, which acts by hindering translocation to the nucleus of the transcription factorNRF2. These data support and extend our previous results and those from other authors on modulation of CN expression and activity levels by the intracellular redox status.

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