Catalytic Use of Strontium Hexamethyldisilazide in the Asymmetric Michael Addition of Malonate to Chalcone Derivatives

2009 ◽  
Vol 38 (3) ◽  
pp. 296-297 ◽  
Author(s):  
Shu Kobayashi ◽  
Miyuki Yamaguchi ◽  
Magno Agostinho ◽  
Uwe Schneider
Keyword(s):  
Michael Addition ◽  
Chalcone Derivatives ◽  
Asymmetric Michael Addition

Organocatalytic regioselective asymmetric Michael addition of azlactones to o-hydroxy chalcone derivatives

2015 ◽  
Vol 13 (20) ◽  
pp. 5698-5709 ◽  
Author(s):  
Shao-Yun Zhang ◽  
Gui-Yu Ruan ◽  
Zhi-Cong Geng ◽  
Nai-Kai Li ◽  
Ming Lv ◽  
...  
Keyword(s):  
Michael Addition ◽  
Optically Active ◽  
Chalcone Derivatives ◽  
Asymmetric Michael Addition

Regio- and enantio-selective Michael addition between azlactones with o-hydroxy chalcone derivatives is reported. Optically active N,O-aminals are obtained in good yields with good to excellent diastereo- and enantio-selectivities.

ChemInform Abstract: Organocatalytic Regioselective Asymmetric Michael Addition of Azlactones to O-Hydroxy Chalcone Derivatives.

ChemInform ◽  
2015 ◽  
Vol 46 (40) ◽  
pp. no-no
Author(s):  
Shao-Yun Zhang ◽  
Gui-Yu Ruan ◽  
Zhi-Cong Geng ◽  
Nai-Kai Li ◽  
Ming Lv ◽  
...  
Keyword(s):  
Michael Addition ◽  
Chalcone Derivatives ◽  
Asymmetric Michael Addition

Enantioselective Michael Addition of Malonates to Enones

2020 ◽  
Vol 24 (7) ◽  
pp. 746-773
Author(s):  
Péter Bakó ◽  
Tamás Nemcsok ◽  
Zsolt Rapi ◽  
György Keglevich
Keyword(s):  
Michael Addition ◽  
Activity Relationship ◽  
Chalcone Derivatives ◽  
Michael Additions ◽  
Michael Reactions ◽  
Structure Activity ◽  
Cyclic Enones ◽  
Michael Acceptors ◽  
Relationship Of ◽  
Enantioselective Catalysts

: Many catalysts were tested in asymmetric Michael additions in order to synthesize enantioenriched products. One of the most common reaction types among the Michael reactions is the conjugated addition of malonates to enones making it possible to investigate the structure–activity relationship of the catalysts. The most commonly used Michael acceptors are chalcone, substituted chalcones, chalcone derivatives, cyclic enones, while typical donors may be dimethyl, diethyl, dipropyl, diisopropyl, dibutyl, di-tert-butyl and dibenzyl malonates. This review summarizes the most important enantioselective catalysts applied in these types of reactions.

Pyrrolidinyl-Camphor Derivatives as a New Class of Organocatalyst for Direct Asymmetric Michael Addition of Aldehydes and Ketones to β-Nitroalkenes

2010 ◽  
Vol 16 (23) ◽  
pp. 7030-7038 ◽  
Author(s):  
Ying-Fang Ting ◽  
Chihliang Chang ◽  
Raju Jannapu Reddy ◽  
Dhananjay R. Magar ◽  
Kwunmin Chen
Keyword(s):  
Michael Addition ◽  
New Class ◽  
Asymmetric Michael Addition ◽  
Aldehydes And Ketones ◽  
Camphor Derivatives

ChemInform Abstract: Asymmetric Michael Addition of Ketones to Nitroolefins: Pyrrolidinyl-oxazole-carboxamides as New Efficient Organocatalysts.

ChemInform ◽  
2015 ◽  
Vol 46 (12) ◽  
pp. no-no
Author(s):  
Ahmed Kamal ◽  
Manda Sathish ◽  
Vunnam Srinivasulu ◽  
Jadala Chetna ◽  
Kunta Chandra Shekar ◽  
...  
Keyword(s):  
Michael Addition ◽  
Asymmetric Michael Addition

scholarly journals Synthesis of new pyrrolidine-based organocatalysts and study of their use in the asymmetric Michael addition of aldehydes to nitroolefins

2017 ◽  
Vol 13 ◽  
pp. 612-619 ◽  
Author(s):  
Alejandro Castán ◽  
Ramón Badorrey ◽  
José A Gálvez ◽  
María D Díaz-de-Villegas
Keyword(s):  
Michael Addition ◽  
Bulky Substituent ◽  
Asymmetric Michael Addition ◽  
Iodination Reaction ◽  
Chiral Imines ◽  
New Compounds ◽  
The Michael Addition

New pyrrolidine-based organocatalysts with a bulky substituent at C2 were synthesized from chiral imines derived from (R)-glyceraldehyde acetonide by diastereoselective allylation followed by a sequential hydrozirconation/iodination reaction. The new compounds were found to be effective organocatalysts for the Michael addition of aldehydes to nitroolefins and enantioselectivities up to 85% ee were achieved.

Asymmetric Michael Addition Induced by (R)-tert-Butanesulfinamide and Syntheses of Chiral Pyrazolidinone Derivatives

2016 ◽  
Vol 81 (21) ◽  
pp. 10506-10516 ◽  
Author(s):  
Hong-Xiu Huang ◽  
Hui-Jing Wang ◽  
Ling Tan ◽  
Shu-Qing Wang ◽  
Pei Tang ◽  
...  
Keyword(s):  
Michael Addition ◽  
Asymmetric Michael Addition

ChemInform Abstract: Catalytic Asymmetric Michael Addition of Nitromethane to Enones Controlled by (R)-LPB.

ChemInform ◽  
2010 ◽  
Vol 29 (52) ◽  
pp. no-no
Author(s):  
K. FUNABASHI ◽  
Y. SAIDA ◽  
M. KANAI ◽  
T. ARAI ◽  
H. SASAI ◽  
...  
Keyword(s):  
Michael Addition ◽  
Asymmetric Michael Addition ◽  
Catalytic Asymmetric
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