scholarly journals Recent Progress in the Structure-Activity Relationship Studies on Antitumor Macrolide Aplyronine A by Using Hybridization of Actin-Depolymerizing Natural Product

2020 ◽  
Author(s):  
Takayuki Ohyoshi ◽  
Hideo Kigoshi
Keyword(s):  
Natural Product ◽  
Recent Progress ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Aplyronine A

Research Progress on the Natural Product Aloperine and Its Derivatives

2021 ◽  
Vol 21 ◽  
Author(s):  
Yu Cheng ◽  
Abdur Rauf ◽  
Xiandao Pan
Keyword(s):  
Natural Product ◽  
Recent Progress ◽  
Molecular Mechanisms ◽  
Structure Activity Relationship ◽  
Research Progress ◽  
Activity Relationship ◽  
Pharmacological Effects ◽  
Structure Activity ◽  
Relationship Of

: In this review, an effort towards the presentation of an all-around account of the recent progress on the natural product, aloperine is made, and the antivirus structure-activity relationship of its derivatives is also summarized comprehensively. In addition, the principal pharmacological effects and corresponding molecular mechanisms of aloperine are discussed. Some new modification directions of aloperine are given in the end, which might be brief guidance for further investigations on the natural product aloperine.

Recent Progress in Methylation of (Hetero)Arenes by Cross-Coupling or C–H Activation

Synlett ◽  
2018 ◽  
Vol 29 (04) ◽  
pp. 375-382 ◽  
Author(s):  
Yahu Liu ◽  
Xuebin Liao ◽  
Lu Hu
Keyword(s):  
Recent Progress ◽  
Cross Coupling ◽  
Structure Activity Relationship ◽  
Biological Properties ◽  
Aryl Halides ◽  
Lead Optimization ◽  
Activity Relationship ◽  
Research Groups ◽  
Structure Activity ◽  
Methyl Effect

Owing to the ‘magic methyl effect’ on a compound’s physical and biological properties, methylation is a strategy frequently used by medicinal chemists in structure–activity relationship studies or in lead optimization. This article highlights the most recent reported methods for the direct methylation of (hetero)arenes, which mainly involve either C–H functionalization or cross-coupling of methylating reagents with (hetero)aryl halides. Methylation of C–H bonds of (hetero)-arenes, which is atom economical, has been explored by several research groups in recent years. Given the unmatchable availability of (hetero)aryl halides, we believe that Ni-catalyzed methylation using iodomethane or deuterated iodomethane as the methyl source is one of the most convenient methods.

Synthesis and Structure–Activity Relationship Studies of C2-Modified Analogs of the Antimycobacterial Natural Product Pyridomycin

2020 ◽  
Vol 63 (3) ◽  
pp. 1105-1131 ◽  
Author(s):  
Maryline Kienle ◽  
Patrick Eisenring ◽  
Barbara Stoessel ◽  
Oliver P. Horlacher ◽  
Samuel Hasler ◽  
...  
Keyword(s):  
Natural Product ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity

scholarly journals Synthesis and Structure–Activity Relationship Study of NBRI16716B, an Antitumor Natural Product

2015 ◽  
Vol 63 (6) ◽  
pp. 463-468 ◽  
Author(s):  
Hikaru Abe ◽  
Chiharu Sakashita ◽  
Manabu Kawada ◽  
Akio Nomoto ◽  
Takumi Watanabe ◽  
...  
Keyword(s):  
Natural Product ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
Structure Activity ◽  
Relationship Study

scholarly journals Recent progress in pyrolyzed carbon materials as electrocatalysts for the oxygen reduction reaction

2020 ◽  
Vol 7 (1) ◽  
pp. 28-36 ◽  
Author(s):  
Chen Ouyang ◽  
Xun Wang
Keyword(s):  
Oxygen Reduction Reaction ◽  
Oxygen Reduction ◽  
Recent Progress ◽  
Carbon Materials ◽  
Pyrolytic Carbon ◽  
Structure Activity Relationship ◽  
Reduction Reaction ◽  
Activity Relationship ◽  
Structure Activity ◽  
Review Reports

This review reports some recent advances in pyrolytic carbon as an ORR catalyst and explores its structure–activity relationship.

scholarly journals Synthetic studies of cystobactamids as antibiotics and bacterial imaging carriers lead to compounds with high in vivo efficacy

2020 ◽  
Vol 11 (5) ◽  
pp. 1316-1334
Author(s):  
Giambattista Testolin ◽  
Katarina Cirnski ◽  
Katharina Rox ◽  
Hans Prochnow ◽  
Verena Fetz ◽  
...  
Keyword(s):  
Natural Product ◽  
Antibacterial Activities ◽  
Structure Activity Relationship ◽  
Activity Relationship ◽  
In Vivo Efficacy ◽  
Structure Activity ◽  
Imaging Probes ◽  
Synthetic Studies

Structure–activity relationship studies of the natural product cystobactamid at four different positions led to novel imaging probes and analogs with superior antibacterial activities and in vivo efficacy.

Sign in / Sign up

Export Citation Format

Share Document