Photochemical Site-specific Mutation of 5-Methylcytosine to Thymine

2008 ◽  
Vol 37 (1) ◽  
pp. 94-95 ◽  
Author(s):  
Takashi Matsumura ◽  
Masayuki Ogino ◽  
Kango Nagayoshi ◽  
Kenzo Fujimoto
Keyword(s):  
Site Specific ◽  
Specific Mutation

Sequence Context Effects on Mutational Properties of cis-Opened Benzo[c]phenanthrene Diol Epoxide−Deoxyadenosine Adducts in Site-Specific Mutation Studies†

Biochemistry ◽  
1999 ◽  
Vol 38 (3) ◽  
pp. 1144-1152 ◽  
Author(s):  
Ingrid Pontén ◽  
Jane M. Sayer ◽  
Anthony S. Pilcher ◽  
Haruhiko Yagi ◽  
Subodh Kumar ◽  
...  
Keyword(s):  
Context Effects ◽  
Sequence Context ◽  
Site Specific ◽  
Specific Mutation ◽  
Diol Epoxide ◽  
Deoxyadenosine Adducts

scholarly journals Phase Variation of Campylobacter jejuni 81-176 Lipooligosaccharide Affects Ganglioside Mimicry and Invasiveness In Vitro

2002 ◽  
Vol 70 (2) ◽  
pp. 787-793 ◽  
Author(s):  
Patricia Guerry ◽  
Christine M. Szymanski ◽  
Martina M. Prendergast ◽  
Thomas E. Hickey ◽  
Cheryl P. Ewing ◽  
...  
Keyword(s):  
Campylobacter Jejuni ◽  
Phase Variation ◽  
Outer Core ◽  
Gene Encoding ◽  
Site Specific ◽  
Reading Frame ◽  
Specific Mutation ◽  
Normal Human ◽  
A Site

ABSTRACT The outer cores of the lipooligosaccharides (LOS) of many strains of Campylobacter jejuni mimic human gangliosides in structure. A population of cells of C. jejuni strain 81-176 produced a mixture of LOS cores which consisted primarily of structures mimicking GM2 and GM3 gangliosides, with minor amounts of structures mimicking GD1b and GD2. Genetic analyses of genes involved in the biosynthesis of the outer core of C. jejuni 81-176 revealed the presence of a homopolymeric tract of G residues within a gene encoding CgtA, an N-acetylgalactosaminyltransferase. Variation in the number of G residues within cgtA affected the length of the open reading frame, and these changes in cgtA corresponded to a change in LOS structure from GM2 to GM3 ganglioside mimicry. Site-specific mutation of cgtA in 81-176 resulted in a major LOS core structure that lacked GalNAc and resembled GM3 ganglioside. Compared to wild-type 81-176, the cgtA mutant showed a significant increase in invasion of INT407 cells. In comparison, a site-specific mutation of the neuC1 gene resulted in the loss of sialic acid in the LOS core and reduced resistance to normal human serum but had no affect on invasion of INT407 cells.

scholarly journals Site Specific Mutation of the Zic2 Locus by Microinjection of TALEN mRNA in Mouse CD1, C3H and C57BL/6J Oocytes

PLoS ONE ◽  
2013 ◽  
Vol 8 (3) ◽  
pp. e60216 ◽  
Author(s):  
Benjamin Davies ◽  
Graham Davies ◽  
Christopher Preece ◽  
Rathi Puliyadi ◽  
Dorota Szumska ◽  
...  
Keyword(s):  
Site Specific ◽  
Specific Mutation

Improving the Catalytic Activity of Phenylalanine Aminotransferase of Escherichia coli by Site-Specific Mutation

1998 ◽  
Vol 864 (1 ENZYME ENGINE) ◽  
pp. 561-564 ◽  
Author(s):  
SZU-PEI WU ◽  
CHICHI LIU ◽  
TZANN-SHUN HWANG ◽  
JIN-TANN CHEN ◽  
HSIN TSAI
Keyword(s):  
Escherichia Coli ◽  
Catalytic Activity ◽  
Site Specific ◽  
Specific Mutation

scholarly journals Maximum-Likelihood Estimation of Site-Specific Mutation Rates in Human Mitochondrial DNA From Partial Phylogenetic Classification

Genetics ◽  
2008 ◽  
Vol 180 (3) ◽  
pp. 1511-1524 ◽  
Author(s):  
Saharon Rosset ◽  
R. Spencer Wells ◽  
David F. Soria-Hernanz ◽  
Chris Tyler-Smith ◽  
Ajay K. Royyuru ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Maximum Likelihood ◽  
Maximum Likelihood Estimation ◽  
Likelihood Estimation ◽  
Mutation Rates ◽  
Site Specific ◽  
Human Mitochondrial Dna ◽  
Specific Mutation ◽  
Phylogenetic Classification

Site-specific mutation of the conserved m62 A m62 A residues of E. coli 16S ribosomal RNA. Effects on ribosome function and activity of the ksgA methyltransferase

1990 ◽  
Vol 1050 (1-3) ◽  
pp. 18-26 ◽  
Author(s):  
Philip R. Cunningham ◽  
Carl J. Weitzmann ◽  
Kelvin Nurse ◽  
Remco Masurel ◽  
Peter H. Van Knippenberg ◽  
...  
Keyword(s):  
Ribosomal Rna ◽  
16S Ribosomal Rna ◽  
Site Specific ◽  
Specific Mutation ◽  
E Coli
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