Reductive Ti-crossed Claisen Condensation between Methyl α-Bromocarboxylates and Acid Chlorides Utilizing a TiCl4–PPh3–N-Methylimidazole Reagent

2007 ◽  
Vol 36 (1) ◽  
pp. 48-49 ◽  
Author(s):  
Akira Iida ◽  
Syogo Nakazawa ◽  
Hidefumi Nakatsuji ◽  
Tomonori Misaki ◽  
Yoo Tanabe
Keyword(s):  
Acid Chlorides ◽  
Claisen Condensation

scholarly journals Powerful Ti-Crossed Claisen Condensation Between Ketene Silyl Acetals or Thioacetals and Acid Chlorides or Acids.

ChemInform ◽  
2007 ◽  
Vol 38 (11) ◽  
Author(s):  
Akira Iida ◽  
Syogo Nakazawa ◽  
Tomohito Okabayashi ◽  
Atsushi Horii ◽  
Tomonori Misaki ◽  
...  
Keyword(s):  
Acid Chlorides ◽  
Claisen Condensation ◽  
Silyl Acetals

Reductive Ti-Crossed Claisen Condensation Between Methyl α-Bromocarboxylates and Acid Chlorides Utilizing a TiCl4—PPh3—N-Methylimidazole Reagent.

ChemInform ◽  
2007 ◽  
Vol 38 (26) ◽  
Author(s):  
Akira Iida ◽  
Syogo Nakazawa ◽  
Hidefumi Nakatsuji ◽  
Tomonori Misaki ◽  
Yoo Tanabe
Keyword(s):  
Acid Chlorides ◽  
Claisen Condensation

Diastereoselective Claisen Condensation-Type Reactions of Alkyl 2,2-Dialkoxycyclopropanecarboxylates with Esters and Acid Chlorides Promoted by Titanium(IV) Chloride

1991 ◽  
Vol 20 (8) ◽  
pp. 1475-1478 ◽  
Author(s):  
Shigeru Shimada ◽  
Kazuhiko Saigo ◽  
Yukihiko Hashimoto ◽  
Yasunari Maekawa ◽  
Takashi Yamashita ◽  
...  
Keyword(s):  
Acid Chlorides ◽  
Claisen Condensation

Powerful Ti-Crossed Claisen Condensation between Ketene Silyl Acetals or Thioacetals and Acid Chlorides or Acids

2006 ◽  
Vol 8 (23) ◽  
pp. 5215-5218 ◽  
Author(s):  
Akira Iida ◽  
Syogo Nakazawa ◽  
Tomohito Okabayashi ◽  
Atsushi Horii ◽  
Tomonori Misaki ◽  
...  
Keyword(s):  
Acid Chlorides ◽  
Claisen Condensation ◽  
Silyl Acetals

Eco-Friendly Synthesis of Peptides Using Fmoc-Amino Acid Chlorides as Coupling Agent Under Biphasic Condition

2020 ◽  
Vol 27 ◽  
Author(s):  
Santosh Y. Khatavi ◽  
K. Kantharaju
Keyword(s):  
Amino Acid ◽  
Acid Chloride ◽  
Acid Ester ◽  
Analytical Techniques ◽  
Peptide Bond ◽  
Amino Acid Ester ◽  
Acid Chlorides ◽  
Peptide Bond Formation ◽  
Green Protocol ◽  
Additional Base

Background: Agro-waste derived solvent media act as a greener process for the peptide bond formation using Nα - Fmoc-amino acid chloride and amino acid ester salt with in situ neutralization and coupling under biphasic condition. The Fmoc-amino acid chlorides are prepared by the reported procedure of freshly distilled SOCl2 with dry CH2Cl2. The protocol found many added advantages such as neutralization of amino acid ester salt and not required additional base for the neutralization, and directly coupling take place with Fmoc-amino acid chloride gave final product dipeptide ester in good to excellent yields. The protocol occurs with complete stereo chemical integrity of the configuration of substrates. Here, we revisited Schotten-Baumann condition, instead of using inorganic base. Objective: To develop green protocol for the synthesis of peptide bond using Fmoc-amino acid chloride with amino acid esters salt. Methods: The final product isolated is analyzed in several spectroscopic and analytical techniques such as FT-IR, 1H-, 13CNMR, Mass spectrometry and RP-HPLC to check stereo integrity and purity of the product. Conclusion: The present method developed greener using natural agro-waste (lemon fruit shell ash) derived solvent medium for the reaction and not required chemical entity.

Noncataleptic neuroleptic agents: 2-(4-(2-(2-Chloro-10,11-dihydrodibenzo[b,f]thiepin-10-yloxy)ethyl)piperazine-1-yl)ethanol and some related compounds

1988 ◽  
Vol 53 (11) ◽  
pp. 2731-2741 ◽  
Author(s):  
Jiří Jílek ◽  
Martin Valchář ◽  
Jiří Holubek ◽  
Nataša Dlohožková ◽  
Josef Pomykáček ◽  
...  
Keyword(s):  
Preclinical Studies ◽  
Acid Chlorides ◽  
Substitution Reactions ◽  
Related Compounds

10-(2-Bromoethoxy)-2-chloro-10,11-dihydrodibenzo[b,f]thiepin (X), prepared by two methods, was subjected to substitution reactions with 2-(1-piperazinyl)ethanol, 3-(1-piperazinyl)propanol, 1-methylpiperazine, 3-(1-piperazinyl)propionamide, piperazine, and 1-(ethoxycarbonyl)piperazine and gave the title compounds II-VII. The alcohol II was esterified by treatment with acid chlorides to compounds VIII and IX. Compounds II, V, and VIII proved to be noncataleptic neuroleptic agents and II (clopithepin, VÚFB-17 076) was selected for preclinical studies.

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