Stereoselective Synthesis of Medium-sized Cyclic Compounds through the Intramolecular Michael-type Reaction Utilizing Alkyne–Hexacarbonyldicobalt Complex Formation

2007 ◽  
Vol 36 (3) ◽  
pp. 474-475 ◽  
Author(s):  
Kennichi Inaba ◽  
Jun Takaya ◽  
Nobuharu Iwasawa
Keyword(s):  
Complex Formation ◽  
Stereoselective Synthesis ◽  
Type Reaction ◽  
Cyclic Compounds

Stereoselective Synthesis of Multisubstituted α-fluoro-β-lactams

2020 ◽  
Vol 24 (18) ◽  
pp. 2169-2180
Author(s):  
Atsushi Tarui ◽  
Yukiko Karuo ◽  
Kazuyuki Sato ◽  
Kentaro Kawai ◽  
Masaaki Omote
Keyword(s):  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Stereoselective Synthesis ◽  
Nucleophilic Substitution Reaction ◽  
Nucleophilic Attack ◽  
Type Reaction ◽  
Lactam Ring ◽  
Metal Catalyzed ◽  
Cyclic Compounds ◽  
Nucleophilic Acyl Substitution

β-Lactams, found in β -lactam antibiotics, are the structurally distorted cyclic compounds being subjected to nucleophilic acyl substitution reaction. α-Fluorination of β -lactams is a simple and expedient approach to control the reactivity of β-lactam ring toward nucleophilic attack, which would hopefully lead to the new design of future antibiotics. From the viewpoint of obtaining multisubstituted α -fluoro-β-lactams, α -bromo-α- fluoro-β-lactams are considered as key compounds for structure functionalization, including nucleophilic substitution reaction, aldol-type reaction and metal-catalyzed crosscoupling reaction. All the reactions can be conducted smoothly to afford a variety of multisubstituted α-fluoro-β-lactams. During the course of the examination, chiral α,α-difluoro- β-lactams and α -bromo-β-fluoro-α-lactams are successfully obtained, which are considered potent precursors for making stereocontrolled multisubstituted α-fluoro-β-lactams.

Stereoselective Synthesis of Hagen's Gland Lactones by Employing Vinylogous Mukaiyama Type Reaction

2019 ◽  
Vol 4 (46) ◽  
pp. 13601-13603 ◽  
Author(s):  
L. Raju Chowhan ◽  
Vipin Singh ◽  
Shanta Raj Lakshmi
Keyword(s):  
Stereoselective Synthesis ◽  
Type Reaction

syn-Selective Reformatsky-Type Reaction of α-Silyl-α-stannylacetic Esters with Aldehydes: Stereoselective Synthesis of (E)- and (Z)-α,β-Unsaturated Esters

Synlett ◽  
1991 ◽  
Vol 1991 (12) ◽  
pp. 911-912 ◽  
Author(s):  
Shuji Akai ◽  
Yasunori Tsuzuki ◽  
Satoshi Matsuda ◽  
Shinji Kitagaki ◽  
Yasuyuki Kita
Keyword(s):  
Stereoselective Synthesis ◽  
Unsaturated Esters ◽  
Type Reaction

Stereoselective synthesis of 3,3′-pyrrolidinyl-spirooxindoles via the Zn(OAc)2-mediated asymmetric Mannich-type reaction

2021 ◽  
pp. 152819
Author(s):  
Guanping Tang ◽  
Samuel K. Akompong ◽  
Lianxun Gao ◽  
Chen Zeng ◽  
Hengjiang Cong ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Type Reaction

scholarly journals Mannich-type Reaction of Methylene Active Compounds with a Chiral Sulfinimine of Trifluoropyruvate: New Highly Stereoselective Synthesis of (S)-α-Trifluoromethyl-Aspartic Acid

2005 ◽  
Vol 2 (3) ◽  
pp. 235-237 ◽  
Author(s):  
Francesco Lazzaro ◽  
Arnaud Gissot ◽  
Marcello Crucianelli ◽  
Francesco Angelis ◽  
Luca Bruche ◽  
...  
Keyword(s):  
Aspartic Acid ◽  
Stereoselective Synthesis ◽  
Active Compounds ◽  
Type Reaction

Stereoselective synthesis of δ-amino-α,β,γ,δ-unsaturated cycloketones via Mannich-type reaction

2020 ◽  
Vol 61 (17) ◽  
pp. 151799
Author(s):  
Long He ◽  
Xue Qin ◽  
Xiao-Yan Qin ◽  
Chun-Lan He ◽  
Shi-Da Wang ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Type Reaction

ChemInform Abstract: Stereoselective Synthesis of Medium-Sized Cyclic Compounds by Means of Tandem Reactions of a Cyclic Oxosulfonium Ylide with Acetates of Baylis-Hillman Adducts.

ChemInform ◽  
2010 ◽  
Vol 33 (15) ◽  
pp. no-no
Author(s):  
Hitoshi Akiyama ◽  
Tetsuya Fujimoto ◽  
Katsuyoshi Ohshima ◽  
Kenji Hoshino ◽  
Yuko Saito ◽  
...  
Keyword(s):  
Stereoselective Synthesis ◽  
Tandem Reactions ◽  
Cyclic Compounds

Stereoselective Synthesis of Vicinal Aminodiols, Diamines and Diaminols by the Use of Enantiopure Aldehydes in the Three-Component Aromatic Mannich-Type Reaction.

ChemInform ◽  
2007 ◽  
Vol 38 (41) ◽  
Author(s):  
Leonardo Cappannini ◽  
Cristina Cimarelli ◽  
Sandra Giuli ◽  
Gianni Palmieri ◽  
Marino Petrini
Keyword(s):  
Stereoselective Synthesis ◽  
Type Reaction
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